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Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease

Van Den Broek, D H N; Geddes, R F; Williams, T L; Chang, Y M; Elliott, J; Jepson, R E


D H N Van Den Broek

R F Geddes

T L Williams

Y M Chang

J Elliott

R E Jepson


Hypercalcemia is commonly associated with chronic kidney disease (CKD) in cats.

To explore the calcitonin response to naturally occurring ionized hypercalcemia in cats with azotemic CKD, and to assess the relationship of plasma calcitonin with ionized calcium, alkaline phosphatase (ALP), and urinary calcium excretion.

Thirty‐three client‐owned cats with azotemic CKD and ionized hypercalcemia from first opinion practice.

Cohort study. Calcitonin was measured with an immunoradiometric assay in heparinized plasma. Simple correlations were assessed with Kendall's rank correlation, and the within‐subject correlations of calcitonin with ionized calcium and other clinicopathological variables were calculated with a bivariate linear mixed effects model.

Calcitonin concentrations above the lower limit of detection (>1.2 pg/mL; range, 1.7–87.2 pg/mL) were observed in 11 of 33 hypercalcemic cats (responders). Blood ionized calcium concentration did not differ significantly between responders (median, 1.59 [1.46, 1.66] mmol/L) and nonresponders (median, 1.48 [1.43, 1.65] mmol/L; P = 0.22). No evidence was found for calcitonin and ionized calcium to correlate between cats (τb = 0.14; P = 0.31; n = 33), but significant positive correlation was evident within individual responders over time (within‐subject correlation coefficient [rwithin], 0.83; 95% confidence interval [CI], 0.63–0.92). Calcitonin correlated negatively over time with plasma ALP (rwithin, −0.55; 95% CI, −0.79 to −0.16).

Conclusions and Clinical Importance:
Calcitonin does not appear to have an important role in calcium metabolism in cats with CKD.


Van Den Broek, D. H. N., Geddes, R. F., Williams, T. L., Chang, Y. M., Elliott, J., & Jepson, R. E. (2018). Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease. Journal of Veterinary Internal Medicine, 32(2), 727-735.

Journal Article Type Article
Acceptance Date Jan 5, 2018
Publication Date Feb 22, 2018
Deposit Date Mar 10, 2018
Publicly Available Date Mar 10, 2018
Print ISSN 0891-6640
Publisher Wiley Open Access
Peer Reviewed Peer Reviewed
Volume 32
Issue 2
Pages 727-735
Public URL