Are mice good models for human neuromuscular disease? Comparing muscle excursions in walking between mice and humans

Hu, X; Charles, J P; Akay, T; Hutchinson, J R; Blemker, S S

Abstract

The mouse is one of the most widely used animal models to study neuromuscular diseases and test new therapeutic strategies. However, findings from successful pre-clinical studies using mouse models frequently fail to translate to humans due to various factors. Differences in muscle function between the two species could be crucial but often have been overlooked. The purpose of this study was to evaluate and compare muscle excursions in walking between mice and humans.

Citation

Hu, X., Charles, J. P., Akay, T., Hutchinson, J. R., & Blemker, S. S. (2017). Are mice good models for human neuromuscular disease? Comparing muscle excursions in walking between mice and humans. Skeletal Muscle, 7(26), https://doi.org/10.1186/s13395-017-0143-9

• Journal Article Type: Article
• Acceptance Date: Oct 26, 2017
• Publication Date: Nov 16, 2017
• Deposit Date: Dec 15, 2017
• Publicly Available Date: Dec 15, 2017
• Journal: Skeletal Muscle
• Publisher: BioMed Central
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Issue: 26
• DOI: https://doi.org/10.1186/s13395-017-0143-9
• Public URL: https://rvc-repository.worktribe.com/output/1390032