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Benign Bilateral Adenomyoepithelioma of the Mammary Gland in a Ring-tailed Lemur (Lemur catta)

Suárez-Bonnet, A; Grau-Bassas, E R; Herráez, P; Quesada-Canales, O; Priestnall, S L; De Los Monteros, A E


A Suárez-Bonnet

E R Grau-Bassas

P Herráez

O Quesada-Canales

S L Priestnall

A E De Los Monteros


Naturally occurring mammary tumours are uncommon in prosimians. A 20-year-old female ring-tailed lemur (Lemur catta) developed bilateral enlargement of the mammary glands. Surgical removal revealed that both masses were comprised of multiple nodules and cystic areas that entirely replaced the normal glands. Histologically, a benign neoplastic biphasic cellular proliferation, composed of luminal–epithelial and basal–myoepithelial components, was identified. Immunohistochemical analysis for expression of cytokeratin (CK) AE1/AE3, CK7, CK5 + 8, CK14, vimentin, p63 and 14-3-3σ highlighted the biphasic nature of the neoplasm. A low mitotic count, low Ki67 labelling index, expression of oestrogen receptor-α, lack of expression of human epidermal growth factor receptor and a 3-year disease-free period without recurrence supported the benign nature of the tumour. Macroscopically, histologically and immunohistochemically this neoplasm resembled benign adenomyoepithelioma of the breast in women. This is the first complete report of a naturally occurring mammary tumour in a ring-tailed lemur.


Suárez-Bonnet, A., Grau-Bassas, E. R., Herráez, P., Quesada-Canales, O., Priestnall, S. L., & De Los Monteros, A. E. (2017). Benign Bilateral Adenomyoepithelioma of the Mammary Gland in a Ring-tailed Lemur (Lemur catta). Journal of Comparative Pathology, 157(2-3), 85-89.

Journal Article Type Article
Acceptance Date Jun 5, 2017
Publication Date Jul 24, 2017
Deposit Date Nov 23, 2017
Publicly Available Date Aug 1, 2018
Print ISSN 0021-9975
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 157
Issue 2-3
Pages 85-89
Public URL


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