Benign Bilateral Adenomyoepithelioma of the Mammary Gland in a Ring-tailed Lemur (Lemur catta)

Suárez-Bonnet, A; Grau-Bassas, E R; Herráez, P; Quesada-Canales, O; Priestnall, S L; De Los Monteros, A E

doi:10.1016/j.jcpa.2017.06.009

Benign Bilateral Adenomyoepithelioma of the Mammary Gland in a Ring-tailed Lemur (Lemur catta)

Suárez-Bonnet, A; Grau-Bassas, E R; Herráez, P; Quesada-Canales, O; Priestnall, S L; De Los Monteros, A E

Authors

A Suárez-Bonnet

E R Grau-Bassas

P Herráez

O Quesada-Canales

S L Priestnall

A E De Los Monteros

Abstract

Naturally occurring mammary tumours are uncommon in prosimians. A 20-year-old female ring-tailed lemur (Lemur catta) developed bilateral enlargement of the mammary glands. Surgical removal revealed that both masses were comprised of multiple nodules and cystic areas that entirely replaced the normal glands. Histologically, a benign neoplastic biphasic cellular proliferation, composed of luminal–epithelial and basal–myoepithelial components, was identified. Immunohistochemical analysis for expression of cytokeratin (CK) AE1/AE3, CK7, CK5 + 8, CK14, vimentin, p63 and 14-3-3σ highlighted the biphasic nature of the neoplasm. A low mitotic count, low Ki67 labelling index, expression of oestrogen receptor-α, lack of expression of human epidermal growth factor receptor and a 3-year disease-free period without recurrence supported the benign nature of the tumour. Macroscopically, histologically and immunohistochemically this neoplasm resembled benign adenomyoepithelioma of the breast in women. This is the first complete report of a naturally occurring mammary tumour in a ring-tailed lemur.

Citation

Suárez-Bonnet, A., Grau-Bassas, E. R., Herráez, P., Quesada-Canales, O., Priestnall, S. L., & De Los Monteros, A. E. (2017). Benign Bilateral Adenomyoepithelioma of the Mammary Gland in a Ring-tailed Lemur (Lemur catta). Journal of Comparative Pathology, 157(2-3), 85-89. https://doi.org/10.1016/j.jcpa.2017.06.009

Journal Article Type	Article
Acceptance Date	Jun 5, 2017
Publication Date	Jul 24, 2017
Deposit Date	Nov 23, 2017
Publicly Available Date	Aug 1, 2018
Journal	JOURNAL OF COMPARATIVE PATHOLOGY
Print ISSN	0021-9975
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	157
Issue	2-3
Pages	85-89
DOI	https://doi.org/10.1016/j.jcpa.2017.06.009
Public URL	https://rvc-repository.worktribe.com/output/1391123