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RNA-binding proteins in human oogenesis: Balancing differentiation and self-renewal in the female fetal germline

Rosario, R; Childs, A J; Anderson, R A

Authors

R Rosario

A J Childs

R A Anderson



Abstract

Primordial germ cells undergo three significant processes on their path to becoming primary oocytes: the initiation of meiosis, the formation and breakdown of germ cell nests, and the assembly of single oocytes into primordial follicles. However at the onset of meiosis, the germ cell becomes transcriptionally silenced. Consequently translational control of pre-stored mRNAs plays a central role in coordinating gene expression throughout the remainder of oogenesis; RNA binding proteins are key to this regulation. In this review we examine the role of exemplars of such proteins, namely LIN28, DAZL, BOLL and FMRP, and highlight how their roles during germ cell development are critical to oogenesis and the establishment of the primordial follicle pool.

Citation

Rosario, R., Childs, A. J., & Anderson, R. A. (2017). RNA-binding proteins in human oogenesis: Balancing differentiation and self-renewal in the female fetal germline. Stem Cell Research, 21, 193-201. https://doi.org/10.1016/j.scr.2017.04.008

Journal Article Type Article
Acceptance Date Apr 13, 2017
Publication Date Apr 18, 2017
Deposit Date Apr 25, 2017
Publicly Available Date Mar 29, 2024
Journal Stem Cell Research
Print ISSN 1873-5061
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 21
Pages 193-201
DOI https://doi.org/10.1016/j.scr.2017.04.008
Public URL https://rvc-repository.worktribe.com/output/1392272

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