R Rosario
RNA-binding proteins in human oogenesis: Balancing differentiation and self-renewal in the female fetal germline
Rosario, R; Childs, A J; Anderson, R A
Authors
A J Childs
R A Anderson
Abstract
Primordial germ cells undergo three significant processes on their path to becoming primary oocytes: the initiation of meiosis, the formation and breakdown of germ cell nests, and the assembly of single oocytes into primordial follicles. However at the onset of meiosis, the germ cell becomes transcriptionally silenced. Consequently translational control of pre-stored mRNAs plays a central role in coordinating gene expression throughout the remainder of oogenesis; RNA binding proteins are key to this regulation. In this review we examine the role of exemplars of such proteins, namely LIN28, DAZL, BOLL and FMRP, and highlight how their roles during germ cell development are critical to oogenesis and the establishment of the primordial follicle pool.
Citation
Rosario, R., Childs, A. J., & Anderson, R. A. (2017). RNA-binding proteins in human oogenesis: Balancing differentiation and self-renewal in the female fetal germline. Stem Cell Research, 21, 193-201. https://doi.org/10.1016/j.scr.2017.04.008
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 13, 2017 |
Publication Date | Apr 18, 2017 |
Deposit Date | Apr 25, 2017 |
Publicly Available Date | Apr 25, 2017 |
Journal | Stem Cell Research |
Print ISSN | 1873-5061 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 21 |
Pages | 193-201 |
DOI | https://doi.org/10.1016/j.scr.2017.04.008 |
Public URL | https://rvc-repository.worktribe.com/output/1392272 |
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