Ventriculo-arterial coupling detects occult RV dysfunction in chronic thromboembolic pulmonary vascular disease

Axell, R G; Messer, S J; White, P A; McCabe, C; Priest, A; Statopoulou, T; Drozdzynska, M; Viscasillas, J; Hinchy, E C; Hampton-Till, J; Alibhai, H I K; Morrell, N; Pepke-Zaba, J; Large, S R; Hoole, S P

Abstract

Chronic thromboembolic disease (CTED) is suboptimally defined by a mean pulmonary artery pressure (mPAP) 0.68 and Ees/Ea < 0.68 subgroups demonstrated constant RV stroke work but lower stroke volume (87.7 ± 22.1 vs. 60.1 ± 16.3 mL respectively, P = 0.006) and higher end‐systolic pressure (36.7 ± 11.6 vs. 68.1 ± 16.7 mmHg respectively, P < 0.001). Lower Ees/Ea in CTED also correlated with reduced exercise ventilatory efficiency. Low Ees/Ea aligns with features of RV maladaptation in CTED both at rest and on exercise. Characterization of Ees/Ea in CTED may allow for better identification of occult RV dysfunction.

Citation

Axell, R. G., Messer, S. J., White, P. A., McCabe, C., Priest, A., Statopoulou, T., …Hoole, S. P. (2017). Ventriculo-arterial coupling detects occult RV dysfunction in chronic thromboembolic pulmonary vascular disease. Physiological Reports, 5(7), https://doi.org/10.14814/phy2.13227

• Journal Article Type: Article
• Acceptance Date: Feb 26, 2017
• Publication Date: Apr 3, 2017
• Deposit Date: Apr 5, 2017
• Publicly Available Date: Apr 5, 2017
• Journal: Physiological Reports
• Publisher: Wiley Open Access
• Peer Reviewed: Peer Reviewed
• Volume: 5
• Issue: 7
• DOI: https://doi.org/10.14814/phy2.13227
• Public URL: https://rvc-repository.worktribe.com/output/1392420