Early animal farming and zoonotic disease dynamics: modelling brucellosis transmission in Neolithic goat populations

Fournié, G; Pfeiffer, D U; Bendrey, R

Abstract

Zoonotic pathogens are frequently hypothesized as emerging with the origins of farming, but evidence of this is elusive in the archaeological records. To explore the potential impact of animal domestication on zoonotic disease dynamics and human infection risk, we developed a model simulating the transmission of Brucella melitensis within early domestic goat populations. The model was informed by archaeological data describing goat populations in Neolithic settlements in the Fertile Crescent, and used to assess the potential of these populations to sustain the circulation of Brucella. Results show that the pathogen could have been sustained even at low levels of transmission within these domestic goat populations. This resulted from the creation of dense populations and major changes in demographic characteristics. The selective harvesting of young male goats, likely aimed at improving the efficiency of food production, modified the age and sex structure of these populations, increasing the transmission potential of the pathogen within these populations. Probable interactions between Neolithic settlements would have further promoted pathogen maintenance. By fostering conditions suitable for allowing domestic goats to become reservoirs of Brucella melitensis, the early stages of agricultural development were likely to promote the exposure of humans to this pathogen.

Citation

Fournié, G., Pfeiffer, D. U., & Bendrey, R. (2017). Early animal farming and zoonotic disease dynamics: modelling brucellosis transmission in Neolithic goat populations. Royal Society Open Science, 4, 160943. https://doi.org/10.1098/rsos.160943

• Journal Article Type: Article
• Acceptance Date: Jan 11, 2017
• Publication Date: Feb 15, 2017
• Deposit Date: Mar 18, 2017
• Publicly Available Date: Mar 18, 2017
• Journal: Royal Society Open Science
• Electronic ISSN: 2054-5703
• Publisher: The Royal Society
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Pages: 160943
• DOI: https://doi.org/10.1098/rsos.160943
• Public URL: https://rvc-repository.worktribe.com/output/1393378