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Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models

Burkitt, M D; Duckworth, C A; Williams, J M; Pritchard, D M


M D Burkitt

C A Duckworth

J M Williams

D M Pritchard


Gastric colonization with Helicobacter pylori induces diverse human pathological conditions, including superficial gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma and its precursors. The treatment of these conditions often relies on the eradication of H. pylori, an intervention that is increasingly difficult to achieve and that does not prevent disease progression in some contexts. There is, therefore, a pressing need to develop new experimental models of H. pylori-associated gastric pathology to support novel drug development in this field. Here, we review the current status of in vivo and ex vivo models of gastric H. pylori colonization, and of Helicobacter-induced gastric pathology, focusing on models of gastric pathology induced by H. pylori, Helicobacter felis and Helicobacter suis in rodents and large animals. We also discuss the more recent development of gastric organoid cultures from murine and human gastric tissue, as well as from human pluripotent stem cells, and the outcomes of H. pylori infection in these systems.


Burkitt, M. D., Duckworth, C. A., Williams, J. M., & Pritchard, D. M. (2017). Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models. Disease Models and Mechanisms, 10(2), 89-104.

Journal Article Type Review
Acceptance Date Jan 15, 2017
Publication Date Feb 1, 2017
Deposit Date Jun 1, 2017
Publicly Available Date Jun 1, 2017
Journal Disease Models and Mechanisms
Print ISSN 1754-8403
Publisher The Company of Biologists
Peer Reviewed Peer Reviewed
Volume 10
Issue 2
Pages 89-104
Public URL


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