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Genome-wide association studies of immune, disease and productivity traits in indigenous chicken ecotypes

Psifidi, A; Banos, G; Matika, O; Desta, T T; Bettridge, J; Hume, D A; Tadelle, D; Christley, R; Wigley, P; Hanotte, O; Kaiser, P


A Psifidi

G Banos

O Matika

T T Desta

J Bettridge

D A Hume

D Tadelle

R Christley

P Wigley

O Hanotte

P Kaiser


The majority of chickens in sub-Saharan Africa are indigenous ecotypes, well adapted to the local environment and raised in scavenging production systems. Although they are generally resilient to disease challenge, routine vaccination and biosecurity measures are rarely applied and infectious diseases remain a major cause of mortality and reduced productivity. Management and genetic improvement programmes are hampered by lack of routine data recording. Selective breeding based on genomic technologies may provide the means to enhance sustainability. In this study, we investigated the genetic architecture of antibody response to four major infectious diseases [infectious bursal disease (IBDV), Marek’s disease (MDV), fowl typhoid (SG), fowl cholera (PM)] and resistance to Eimeria and cestode parasitism, along with two production traits [body weight and body condition score (BCS)] in two distinct indigenous Ethiopian chicken ecotypes. We conducted variance component analyses, genome-wide association studies, and pathway and selective sweep analyses.


Psifidi, A., Banos, G., Matika, O., Desta, T. T., Bettridge, J., Hume, D. A., …Kaiser, P. (2016). Genome-wide association studies of immune, disease and productivity traits in indigenous chicken ecotypes. Genetics Selection Evolution, 48(74),

Journal Article Type Article
Acceptance Date Sep 15, 2016
Publication Date Sep 29, 2016
Deposit Date Feb 21, 2018
Publicly Available Date Feb 21, 2018
Journal Genetics Selection Evolution
Print ISSN 0999-193X
Publisher BioMed Central
Peer Reviewed Peer Reviewed
Volume 48
Issue 74
Public URL


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