Adaptive responses to cefotaxime treatment in ESBL-producing Escherichia coli and the possible use of significantly regulated pathways as novel secondary targets

Møller, T S B; Rau, M H; Bonde, C S; Sommer, M O A; Guardabassi, L; Olsen, J E

Abstract

The aim of the study was to determine how ESBL-producing Escherichia coli change the expression of metabolic and biosynthesis genes when adapting to inhibitory concentrations of cefotaxime. Secondly, it was investigated whether significantly regulated pathways constitute putative secondary targets that can be used to combat the resistant bacteria.

Citation

Møller, T. S. B., Rau, M. H., Bonde, C. S., Sommer, M. O. A., Guardabassi, L., & Olsen, J. E. (in press). Adaptive responses to cefotaxime treatment in ESBL-producing Escherichia coli and the possible use of significantly regulated pathways as novel secondary targets. Journal of Antimicrobial Chemotherapy, 71(9), 2449-2459. https://doi.org/10.1093/jac/dkw198

• Journal Article Type: Article
• Acceptance Date: Apr 26, 2016
• Deposit Date: Sep 5, 2018
• Journal: Journal of Antimicrobial Chemotherapy
• Print ISSN: 0305-7453
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 71
• Issue: 9
• Pages: 2449-2459
• DOI: https://doi.org/10.1093/jac/dkw198
• Public URL: https://rvc-repository.worktribe.com/output/1396865