Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline

Crawford, A H; Tripathi, R B; Richardson, W D; Franklin, R J M

doi:10.1016/j.celrep.2016.03.069

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline

Crawford, A H; Tripathi, R B; Richardson, W D; Franklin, R J M

Authors

A H Crawford

R B Tripathi

W D Richardson

R J M Franklin

Abstract

Oligodendrocyte progenitors (OPs) arise from distinct ventral and dorsal domains within the ventricular germinal zones of the embryonic CNS. The functional significance, if any, of these different populations is not known. Using dual-color reporter mice to distinguish ventrally and dorsally derived OPs, we show that, in response to focal demyelination of the young adult spinal cord or corpus callosum, dorsally derived OPs undergo enhanced proliferation, recruitment, and differentiation as compared with their ventral counterparts, making a proportionally larger contribution to remyelination. However, with increasing age (up to 13 months), the dorsally derived OPs become less able to differentiate into mature oligodendrocytes. Comparison of dorsally and ventrally derived OPs in culture revealed inherent differences in their migration and differentiation capacities. Therefore, the responsiveness of OPs to demyelination, their contribution to remyelination, and their susceptibility to age-associated functional decline are markedly dependent on their developmental site of origin in the developing neural tube.

Citation

Crawford, A. H., Tripathi, R. B., Richardson, W. D., & Franklin, R. J. M. (2016). Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline. Cell Reports, 15(4), 761-773. https://doi.org/10.1016/j.celrep.2016.03.069

Journal Article Type	Article
Acceptance Date	Mar 17, 2016
Publication Date	Apr 14, 2016
Deposit Date	Aug 23, 2018
Publicly Available Date	Aug 30, 2018
Journal	Cell Reports
Print ISSN	2211-1247
Publisher	Cell Press
Peer Reviewed	Peer Reviewed
Volume	15
Issue	4
Pages	761-773
DOI	https://doi.org/10.1016/j.celrep.2016.03.069
Public URL	https://rvc-repository.worktribe.com/output/1397031