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Disorganization of the splenic microanatomy in ageing mice

Aw, D P S; Hilliard, L; Nishikawa, Y; Cadman, E T; Lawrence, R A; Palmer, D B


D P S Aw

L Hilliard

Y Nishikawa

E T Cadman

R A Lawrence

D B Palmer


The precise mechanisms responsible for immunosenescence still remain to be determined, however, considering the evidence that disruption of the organization of primary and secondary lymphoid organs results in immunodeficiency, we propose that this could be involved in the decline of immune responses with age. Therefore, we investigated the integrity of the splenic microarchitecture in mice of increasing age and its reorganization following immune challenge in young and old mice. Several differences in the anatomy of the spleen with age in both the immune and stromal cells were observed. There is an age‐related increase in the overall size of the white pulp, which occurs primarily within the T‐cell zone and is mirrored by the enlargement of the T‐cell stromal area, concurrent to the distinct boundary between T cells and B cells becoming less defined in older mice. In conjunction, there appears to be a loss of marginal zone macrophages, which is accompanied by an accumulation of fibroblasts in the spleens from older animals. Furthermore, whereas the reorganization of the white pulp is resolved after several days following antigenic challenge in young animals, it remains perturbed in older subjects. All these age‐related changes within the spleen could potentially contribute to the age‐dependent deficiencies in functional immunity.


Aw, D. P. S., Hilliard, L., Nishikawa, Y., Cadman, E. T., Lawrence, R. A., & Palmer, D. B. (2016). Disorganization of the splenic microanatomy in ageing mice. Immunology, 148(1), 92-101.

Journal Article Type Article
Acceptance Date Jan 28, 2016
Publication Date Mar 17, 2016
Deposit Date Feb 18, 2016
Publicly Available Date Feb 18, 2016
Print ISSN 0019-2805
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 148
Issue 1
Pages 92-101
Public URL


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