Effects of Functional Electrical Stimulation on Denervated Laryngeal Muscle in a Large Animal Model

Cheetham, J; Perkins, J D M; Jarvis, J C; Cercone, M; Maw, M; Hermanson, J W; Mitchell, L M; Piercy, R J; Ducharme, N G

Abstract

Bilateral vocal fold paralysis (BVCP) is a life‐threatening condition that follows injury to the Recurrent Laryngeal nerve (RLn) and denervation of the intrinsic laryngeal musculature. Functional electrical stimulation (FES) enables restoration and control of a wide variety of motor functions impaired by lower motor neuron lesions. Here we evaluate the effects of FES on the sole arytenoid abductor, the posterior cricoarytenoid (PCA) muscle in a large animal model of RLn injury. Ten horses were instrumented with two quadripolar intramuscular electrodes in the left PCA muscle. Following a 12‐week denervation period, the PCA was stimulated using a once‐daily training session for 8 weeks in seven animals. Three animals were used as unstimulated controls. Denervation produced a significant increase in rheobase (P 

Citation

Cheetham, J., Perkins, J. D. M., Jarvis, J. C., Cercone, M., Maw, M., Hermanson, J. W., Mitchell, L. M., Piercy, R. J., & Ducharme, N. G. (2015). Effects of Functional Electrical Stimulation on Denervated Laryngeal Muscle in a Large Animal Model. Artificial Organs, 39(10), 876-885. https://doi.org/10.1111/aor.12624

• Journal Article Type: Article
• Acceptance Date: Oct 15, 2015
• Publication Date: Oct 16, 2015
• Deposit Date: Dec 17, 2015
• Publicly Available Date: Dec 17, 2015
• Journal: Artificial Organs
• Print ISSN: 0160-564X
• Electronic ISSN: 1525-1594
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 39
• Issue: 10
• Pages: 876-885
• DOI: https://doi.org/10.1111/aor.12624
• Public URL: https://rvc-repository.worktribe.com/output/1399413