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Genomic analysis of the causative agents of coccidiosis in domestic chickens

Reid, A J; Blake, D P; Ansari, H R; Billington, K; Browne, H P; Bryant, J; Dunn, M; Hung, S S; Kawahara, F; Miranda-Saavedra, D; Malas, T B; Mourier, T; Naghra, H; Nair, M; Otto, T D; Rawlings, N D; Rivailler, P; Sanchez-Flores, A; Sanders, M; Subramaniam, C; Tay, Y-L; Woo, Y; Wu, X; Barrell, B; Dear, P H; Doerig, C; Gruber, A; Ivens, A C; Parkinson, J; Rajandream, M-A; Shirley, M W; Wan, K-L; Berriman, M; Tomley, F M; Pain, A


A J Reid

D P Blake

H R Ansari

K Billington

H P Browne

J Bryant

M Dunn

S S Hung

F Kawahara

D Miranda-Saavedra

T B Malas

T Mourier

H Naghra

M Nair

T D Otto

N D Rawlings

P Rivailler

A Sanchez-Flores

M Sanders

C Subramaniam

Y-L Tay

Y Woo

X Wu

B Barrell

P H Dear

C Doerig

A Gruber

A C Ivens

J Parkinson

M-A Rajandream

M W Shirley

K-L Wan

M Berriman

F M Tomley

A Pain


Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.


Reid, A. J., Blake, D. P., Ansari, H. R., Billington, K., Browne, H. P., Bryant, J., …Pain, A. (in press). Genomic analysis of the causative agents of coccidiosis in domestic chickens. Genome Research, 24(10), 1676-1685.

Journal Article Type Article
Acceptance Date Jul 8, 2014
Deposit Date Nov 12, 2014
Publicly Available Date Nov 12, 2014
Journal Genome Research
Print ISSN 1088-9051
Publisher Cold Spring Harbor Laboratory Press
Peer Reviewed Peer Reviewed
Volume 24
Issue 10
Pages 1676-1685
Public URL


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