Antimicrobial activity of polyhexamethylene biguanide nanoparticles against mastitis-causing Staphylococcus aureus

Leite, R F; Gonçalves, J L; Buanz, A; Febraro, C; Craig, D; Van Winden, S; Good, L; Santos, M V

Abstract

Polyhexamethylene biguanide (PHMB) nanoparticles (NP) developed for this study presented antimicrobial activity against mastitis-causing Staphylococcus aureus at lower concentrations than PHMB alone, chlorhexidine digluconate, povidone-iodine, and sodium dichloroisocyanurate. Thus, PHMB NP present potential for the development of new dipping solutions. Highlights • The PHMB NP were developed by layer-by-layer assembly. • Mastitis-causing Staph. aureus were inhibited by PHMB NP at low concentrations relative to commonly used teat-dip ingredients. • The NP formulation potentiated the antimicrobial activity of PHMB.

Citation

Leite, R. F., Gonçalves, J. L., Buanz, A., Febraro, C., Craig, D., Van Winden, S., …Santos, M. V. (in press). Antimicrobial activity of polyhexamethylene biguanide nanoparticles against mastitis-causing Staphylococcus aureus. Journal of Dairy Science, https://doi.org/10.3168/jdsc.2021-0114

• Journal Article Type: Article
• Acceptance Date: May 23, 2021
• Online Publication Date: Jul 1, 2021
• Deposit Date: Jul 23, 2021
• Print ISSN: 0022-0302
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.3168/jdsc.2021-0114
• Public URL: https://rvc-repository.worktribe.com/output/1550189