Antimicrobial activity of polyhexamethylene biguanide nanoparticles against mastitis-causing Staphylococcus aureus

Leite, R F; Gonçalves, J L; Buanz, A; Febraro, C; Craig, D; Van Winden, S; Good, L; Santos, M V

Abstract

Polyhexamethylene biguanide (PHMB) nanoparticles (NP) developed for this study presented antimicrobial activity against mastitis-causing Staphylococcus aureus at lower concentrations than PHMB alone, chlorhexidine digluconate, povidone-iodine, and sodium dichloroisocyanurate. Thus, PHMB NP present potential for the development of new dipping solutions. Highlights • The PHMB NP were developed by layer-by-layer assembly. • Mastitis-causing Staph. aureus were inhibited by PHMB NP at low concentrations relative to commonly used teat-dip ingredients. • The NP formulation potentiated the antimicrobial activity of PHMB.

Citation

Leite, R. F., Gonçalves, J. L., Buanz, A., Febraro, C., Craig, D., Van Winden, S., Good, L., & Santos, M. V. (in press). Antimicrobial activity of polyhexamethylene biguanide nanoparticles against mastitis-causing Staphylococcus aureus. Journal of Dairy Science, https://doi.org/10.3168/jdsc.2021-0114

• Journal Article Type: Article
• Acceptance Date: May 23, 2021
• Online Publication Date: Jul 1, 2021
• Deposit Date: Jul 23, 2021
• Journal: Journal of Dairy Science
• Print ISSN: 0022-0302
• Electronic ISSN: 1525-3198
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.3168/jdsc.2021-0114
• Public URL: https://rvc-repository.worktribe.com/output/1550189