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Detection of Clade 2.3.4.4b Avian Influenza A(H5N8) Virus in Cambodia, 2021

Edwards, KM; Siegers, JY; Wei, XM; Aziz, A; Deng, YM; Yann, S; Bun, C; Bunnary, S; Izzard, L; Hak, M; Thielen, P; Tum, S; Wong, F; Lewis, NS; James, J; Claes, F; Barr, IG; Dhanasekaran, V; Karlsson, EA

Authors

KM Edwards

JY Siegers

XM Wei

A Aziz

YM Deng

S Yann

C Bun

S Bunnary

L Izzard

M Hak

P Thielen

S Tum

F Wong

NS Lewis

J James

F Claes

IG Barr

V Dhanasekaran

EA Karlsson



Abstract

Institute in Cambodia have partnered with the Food and Agriculture Organization of the United Nations to enhance ongoing longitudinal AIV surveillance in live bird markets and poultry storage facilities throughout Cambodia. This active surveillance reveals high levels of AIV circulation with approximate to 30%-50% of ducks and approximate to 20%-40% of chickens testing positive for various influenza A subtypes. Most detected HPAIVs were H5N1 HA clade 1 viruses during 2005-2014 and H5N1 HA clade 2.3.2.1c viruses since 2014; H5N6 clades 2.3.4.4g and 2.3.4.4h were detected sporadically during 2018-2020 (Appendix 1 Table 1, https:// pdf). Other subtypes also circulate, including novel H7Nx low pathogenicity avian influenza viruses proval no. 149/NECHR/2020) in late 2021, domestic n = 1), Takmao (Kandal, n = 2), Chba Ampov (Phnom Penh, n = 1), and Takeo (Takeo, n = 1) tested positive for HPAIV H5 HA but negative for neuraminidase PCR (RT-PCR). We determined these samples were the H5N8 subtype after further RT-PCR analysis (Ap

Citation

Edwards, K., Siegers, J., Wei, X., Aziz, A., Deng, Y., Yann, S., …Karlsson, E. (2022). Detection of Clade 2.3.4.4b Avian Influenza A(H5N8) Virus in Cambodia, 2021. Emerging Infectious Disease, 29(1), 170-174. https://doi.org/10.3201/eid2901.220934

Journal Article Type Article
Acceptance Date Dec 3, 2022
Publication Date Dec 17, 2022
Deposit Date Aug 24, 2023
Publicly Available Date Aug 24, 2023
Print ISSN 1080-6040
Electronic ISSN 1080-6059
Publisher Centers for Disease Control and Prevention
Peer Reviewed Peer Reviewed
Volume 29
Issue 1
Pages 170-174
DOI https://doi.org/10.3201/eid2901.220934

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