Demonstration of Angiostrongylus vasorum associated hyperfibrinolysis and its resolution following tranexamic acid on the VCM VetTM

Beeston, David; Cortellini, Stefano

Abstract

This case report details the clinical investigation of an 11-month intact male Cockapoo who presented with acute left forebrain signs associated with suspected intra-cranial haemorrhage due to Angiostrongylus vasorum.

Initial investigations failed to identify a coagulopathy using traditional coagulation testing. Subsequent viscoelastic testing using the Viscoelastic Coagulation Monitor (VCM VetTMa) identified a hypocoagulable, hyperfibrinolytic trace. Anti-fibrinolytic treatment with tranexamic acid showed improvement of hypocoagulability and normalisation of hyperfibrinolysis. Subsequent canine fresh frozen plasma transfusion and treatment of the underlying A. vasorum led to resolution of the patient’s coagulopathy.

This case report demonstrates the ease of use and utility of viscoelastic monitoring in global assessment of coagulation and is the first case to document hyperfibrinolysis using the VCM VetTMa in a patient with A. vasorum.

Citation

Beeston, D., & Cortellini, S. (in press). Demonstration of Angiostrongylus vasorum associated hyperfibrinolysis and its resolution following tranexamic acid on the VCM VetTM. Veterinary Record,

• Journal Article Type: Article
• Acceptance Date: Jun 15, 2023
• Online Publication Date: Jun 30, 2023
• Deposit Date: Feb 19, 2024
• Publicly Available Date: Feb 20, 2024
• Journal: Veterinary Record
• Print ISSN: 0042-4900
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed