Ammonia impairs neutrophil phagocytic function in liver disease
Journal Article
Shawcross, D. L., Wright, G. A. K., Stadlbauer, V., Hodges, S. J., Davies, N. A., Wheeler-Jones, C. P. D., Pitsillides, A. A., & Jalan, R. Ammonia impairs neutrophil phagocytic function in liver disease. Hepatology, 48(4), 1202-12. https://doi.org/10.1002/hep.22474
All Outputs (161)
Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts
Journal Article
Chen, Y. L., Leask, A., Abraham, D. J., Pala, D., Xu, S. W., Khan, K., Liu, S. X., Carter, D. E., Wilcox-Adelman, S., Goetinck, P., Denton, C. P., Black, C. M., Pitsillides, A. A., Sarraf, C. E., & Eastwood, M. Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts. Arthritis and Rheumatism, 58(2), 577-585. https://doi.org/10.1002/art.23146Objective. To investigate the contribution of heparan sulfate proteoglycan and Ras/MEK/ERK to the overexpression of profibrotic proteins and the enhanced contractile ability of dermal fibroblasts from patients with systemic sclerosis (SSc; scleroderm... Read More about Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.
Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells
Journal Article
Clarkin, C. E., Emery, R. J., Pitsillides, A. A., & Wheeler-Jones, C. P. D. Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells. Journal of Cellular Physiology, 214(2), 537-544. https://doi.org/10.1002/jcp.21234Communication between endothelial and bone cells is crucial for controlling vascular supply during bone growth, remodeling, and repair but the molecular mechanisms coordinating this intercellular crosstalk remain ill-defined. We have used primary hum... Read More about Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells.
Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?
Journal Article
Clarkin, C. E., Garonna, E., Pitsillides, A. A., & Wheeler-Jones, C. P. D. Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?. Experimental Cell Research, 314(17), 3152-3161. https://doi.org/10.1016/j.yexcr.2008.07.027in bone, angiogenesis most be initiated appropriately, but limited once remodelling or repair is complete. Our recent findings have Supported a role for prostaglandins (PG), known modulators of osteoblast (OB) and endothelial cell (EC) behaviour, in... Read More about Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?.
A critical evaluation of specific aspects of joint development
Journal Article
Pitsillides, A. A., & Ashhurst, D. E. A critical evaluation of specific aspects of joint development. Developmental Dynamics, 237(9), 2284-2294. https://doi.org/10.1002/dvdy.21654Synovial joint formation has been divided into two phases; the formation of the anlagen of the opposing bones and the interzone and the later formation of the joint cavity. Here we review current theories on the mechanism by which these events are ac... Read More about A critical evaluation of specific aspects of joint development.
A NOVEL PROFILE ANALYSIS OF METAPHYSEAL TRABECULAR BONE REVEALS A BIPHASIC DOSE-DEPENDENT RESPONSE TO ADMINISTERED BONE ACTIVE AGENTS
Journal Article
Salmon, P., Pitsillides, A. A., Tivesten, A., Moverare-Skrtic, S., Ohlsson, C., Oste, L., Dixon, G., Idris, A., & Van T'Hof, R. A NOVEL PROFILE ANALYSIS OF METAPHYSEAL TRABECULAR BONE REVEALS A BIPHASIC DOSE-DEPENDENT RESPONSE TO ADMINISTERED BONE ACTIVE AGENTS
Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis
Journal Article
Staines, K. A., Ikpegbu, E., Tornqvist, A. E., Dillon, S., Javaheri, B., Amin, A. K., Clements, D. N., Buttle, D. J., Pitsillides, A. A., & Farquharson, C. (in press). Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis. BMC Musculoskeletal Disorders, 20, https://doi.org/10.1186/s12891-019-2731-9Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption to the SCB o... Read More about Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis.
The in vitro behaviour of canine osteoblasts derived from different bone types
Journal Article
Meeson, R. L., Perpétuo, I. P., Parsons, K. J., Orriss, I. R., Shah, M., Pitsillides, A. A., & Doube, M. (in press). The in vitro behaviour of canine osteoblasts derived from different bone types. BMC Veterinary Research, 15(114), https://doi.org/10.1186/s12917-019-1857-1
In Vivo Models of Mechanical Loading
Journal Article
Javaheri, B., Bravenboer, N., Bakker, A. D., Van Der Veen, A., De Souza, R. L., Saxon, L., & Pitsillides, A. A. In Vivo Models of Mechanical Loading. https://doi.org/10.1007/978-1-4939-8997-3_22The skeleton fulfils its mechanical functions through structural organization and material properties of individual bones. It is stated that both cortical and trabecular morphology and mass can be (re)modelled in response to changes in mechanical str... Read More about In Vivo Models of Mechanical Loading.
Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo
Journal Article
Javaheri, B., Hopkinson, M., Poulet, B., Pollard, A. S., Shefelbine, S. J., Chang, Y. M., Francis-West, P., Bou-Gharios, G., & Pitsillides, A. A. (in press). Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo. PLoS ONE, 11(8), e0159657. https://doi.org/10.1371/journal.pone.0159657
The anabolic action of intermittent parathyroid hormone on cortical bone depends partly on its ability to induce nitric oxide-mediated vasorelaxation in BALB/c mice
Journal Article
Gohin, S., Carriero, A., Chenu, C., Pitsillides, A. A., Arnett, T. R., & Marenzana, M. (in press). The anabolic action of intermittent parathyroid hormone on cortical bone depends partly on its ability to induce nitric oxide-mediated vasorelaxation in BALB/c mice. Cell Biochemistry and Function, 34(2), 52-62. https://doi.org/10.1002/cbf.3164
SPONTANEOUS HOME CAGE ACTIVITY IS SENSITIVE TO ANTI-NGF TREATMENT OR CAN BE LINKED TO JOINT STIFFNESS IN DIFFERENT MODELS OF SURGERY-INDUCED OSTEOARTHRITIS
Journal Article
Brenneis, C., Westhof, A., Duschek, J., Chang, Y. M., Pitsillides, A. A., Michaelis, M., Kleinschmidt, K., & Guehring, H. SPONTANEOUS HOME CAGE ACTIVITY IS SENSITIVE TO ANTI-NGF TREATMENT OR CAN BE LINKED TO JOINT STIFFNESS IN DIFFERENT MODELS OF SURGERY-INDUCED OSTEOARTHRITIS
PENALIZED LINEAR DISCRIMINANT ANALYSIS REVEALS DIVERGENT GAIT PATTERNS IN THREE SURGICALLY-INDUCED OA MODELS
Journal Article
Chang, Y. M., Marsh-Dougerthy, J., Brenneis, C., Kleinschmidt, K., Michaelis, M., Guehring, H., Piles, M., & Pitsillides, A. A. PENALIZED LINEAR DISCRIMINANT ANALYSIS REVEALS DIVERGENT GAIT PATTERNS IN THREE SURGICALLY-INDUCED OA MODELS
Non-Invasive Mouse Models of Post-Traumatic Osteoarthritis
Journal Article
Christiansen, B. A., Guilak, F., Lockwood, K. A., Olson, S. A., Pitsillides, A. A., Sandell, L. J., Silva, M. J., Van Der Meulen, M. C. H., & Haudenschild, D. R. (in press). Non-Invasive Mouse Models of Post-Traumatic Osteoarthritis. Osteoarthritis and Cartilage, 23(10), 1627-1638. https://doi.org/10.1016/j.joca.2015.05.009
MMP and TIMP temporal gene expression during osteocytogenesis
Journal Article
Prideaux, M., Staines, K. A., Jones, E. R., Riley, G. P., Pitsillides, A. A., & Farquharson, C. (in press). MMP and TIMP temporal gene expression during osteocytogenesis. Gene Expression Patterns, 18(1-2), 29-36. https://doi.org/10.1016/j.gep.2015.04.004Osteocytes within bone differentiate from osteoblast precursors which reside in a mineralised extracellular matrix (ECM). Fully differentiated osteocytes are critical for bone development and function but the factors that regulate this differentiatio... Read More about MMP and TIMP temporal gene expression during osteocytogenesis.
GENDER DIFFERENCES OA PROGRESSION AND THEIR LONGITUDINAL GAIT CHANGES
Journal Article
Piles, M., De Souza, R., Poulet, B., Pitsillides, A. A., & Chang, Y. M. GENDER DIFFERENCES OA PROGRESSION AND THEIR LONGITUDINAL GAIT CHANGES
SYSTEMATIZING MURINE MENISCAL AND LIGAMENT MODIFICATIONS DURING OSTEOARTHRITIS
Journal Article
Poulet, B., Bou-Gharios, G., & Pitsillides, A. A. SYSTEMATIZING MURINE MENISCAL AND LIGAMENT MODIFICATIONS DURING OSTEOARTHRITIS
E11 PROTEIN STABILISATION BY PROTEASOME INHIBITION PROMOTES OSTEOCYTE DIFFERENTIATION AND MAY PROTECT AGAINST OSTEOARTHRITIS BONE PATHOLOGY
Journal Article
Staines, K. A., Prideaux, M., Hohenstein, P., Buttle, D. J., Pitsillides, A. A., & Farquharson, C. E11 PROTEIN STABILISATION BY PROTEASOME INHIBITION PROMOTES OSTEOCYTE DIFFERENTIATION AND MAY PROTECT AGAINST OSTEOARTHRITIS BONE PATHOLOGY
FSTL3: A NOVEL REGULATOR OF GROWTH PLATE DYNAMICS?
Journal Article
Burleigh, A., Staines, K. A., Poulet, B., Pitsillides, A. A., & Mukherjee, A. FSTL3: A NOVEL REGULATOR OF GROWTH PLATE DYNAMICS?
Ex vivo determination of bone tissue strains for an in vivo mouse tibial loading model
Journal Article
Carriero, A., Abela, L., Pitsillides, A. A., & Shefelbine, S. J. Ex vivo determination of bone tissue strains for an in vivo mouse tibial loading model. Journal of Biomechanics, 18(47), 2490-2497. https://doi.org/10.1016/j.jbiomech.2014.03.035