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All Outputs (49)

Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds (2025)
Journal Article
Meunier, D., Corona-Torres, R., Boulton, K., Wu, Z., Ballantyne, M., Glendinning, L., Ahmad, A. A., Borowska, D., Taylor, L., Vervelde, L., del Pozo, J., Vasilogianni, M., Jaramillo-Ortiz, J., Sanchez-Arsuaga, G., Psifidi, A., Tomley, F., Watson, K. A., McGrew, M. J., Stevens, M. P., Blake, D. P., & Hume, D. A. (2025). Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds. eLife, https://doi.org/10.7554/elife.106252.1

Effective mucosal immunity in the intestine involves a fine balance between tolerance of the microbiome, recognition and elimination of pathogens, and inflammatory tissue injury. The anti-inflammatory cytokine IL10 regulates these processes in the in... Read More about Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds.

Growth resilience to weather variation in commercial free-ranging chickens in Ethiopia (2025)
Journal Article
Banos, G., Girma, M., Solomon, B., Davoudi, P., Esatu, W., Dessie, T., Psifidi, A., Watson, K., Hanotte, O., & Sánchez-Molano, E. (2025). Growth resilience to weather variation in commercial free-ranging chickens in Ethiopia. BMC Genomics, 26(1), https://doi.org/10.1186/s12864-025-11561-6

BackgroundThe poultry industry in sub-Saharan Africa is a rapidly developing sector mostly based on smallholder farming. Increased demand for poultry-derived products, driven by the growing economy and population, has intensified importations of high... Read More about Growth resilience to weather variation in commercial free-ranging chickens in Ethiopia.

β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy (2025)
Journal Article
Huo, Y., Shen, T., Feng, T., Li, M., Zhao, W., Loor, J., Aernouts, B., Psifidi, A., & Xu, C. (2025). β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy. Journal of Animal Science and Biotechnology, 16(1), https://doi.org/10.1186/s40104-024-01143-z

BackgroundIn perinatal dairy cows, ketosis is a prevalent metabolic disorder that lowers milk output and performance. Mitochondrial dysfunction and chronic inflammation in mammary tissue are linked to elevated blood ketone levels, particularly beta-h... Read More about β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy.

Impact of commercial gut health interventions on caecal metagenome and broiler performance (2025)
Journal Article
Pangga, G., Star-Shirko, B., Psifidi, A., Xia, D., Corcionivoschi, N., Kelly, C., Hughes, C., Lavery, U., Richmond, A., Ijaz, U., & Gundogdu, O. (2025). Impact of commercial gut health interventions on caecal metagenome and broiler performance. Microbiome, 13(1), https://doi.org/10.1186/s40168-024-02012-7

BackgroundMaintaining gut health is a persistent and unresolved challenge in the poultry industry. Given the critical role of gut health in chicken performance and welfare, there is a pressing need to identify effective gut health intervention (GHI)... Read More about Impact of commercial gut health interventions on caecal metagenome and broiler performance.

Identification of DNA methylation markers for age and Bovine Respiratory Disease in dairy cattle: A pilot study based on Reduced Representation Bisulfite Sequencing (2024)
Journal Article
Attree, E., Griffiths, B., Panchal, K., Xia, D., Werling, D., Banos, G., Oikonomou, G., & Psifidi, A. (in press). Identification of DNA methylation markers for age and Bovine Respiratory Disease in dairy cattle: A pilot study based on Reduced Representation Bisulfite Sequencing. Communications Biology, 7(1), https://doi.org/10.1038/s42003-024-06925-9

Epigallocatechin-3-gallate protects bovine ruminal epithelial cells against lipopolysaccharide-induced inflammatory damage by activating autophagy (2024)
Journal Article
Zhao, W., Shen, T., Zhao, B., Li, M., Deng, Z., Huo, Y., Aernouts, B., Loor, J., Psifidi, A., & Xu, C. (2024). Epigallocatechin-3-gallate protects bovine ruminal epithelial cells against lipopolysaccharide-induced inflammatory damage by activating autophagy. Journal of Animal Science and Biotechnology, 15(1), https://doi.org/10.1186/s40104-024-01066-9

BackgroundSubacute ruminal acidosis (SARA) causes an increase in endotoxin, which can induce immune and inflammatory responses in the ruminal epithelium of dairy cows. In non-ruminants, epigallocatechin-3-gallate (EGCG), a major bioactive ingredient... Read More about Epigallocatechin-3-gallate protects bovine ruminal epithelial cells against lipopolysaccharide-induced inflammatory damage by activating autophagy.

Characterisation of phenotypic patterns in equine exercise-associated myopathies (2024)
Journal Article
Lindsay-McGee, V., Massey, C., Li, Y., Clark, E., Psifidi, A., & Piercy, R. (2024). Characterisation of phenotypic patterns in equine exercise-associated myopathies. Equine Veterinary Journal, https://doi.org/10.1111/evj.14128

Background Equine exercise-associated myopathies are prevalent, clinically heterogeneous, generally idiopathic disorders characterised by episodes of myofibre damage that occur in association with exercise. Episodes are intermittent and vary within a... Read More about Characterisation of phenotypic patterns in equine exercise-associated myopathies.

A prospective cohort study of factors associated with the digital cushion thickness in dairy cattle (2024)
Journal Article
Griffiths, B., Barden, M., Anagnostopoulos, A., Wilson, J., Lamprou, E., Tulley, W., Bedford, C., Psifidi, A., Banos, G., & Oikonomou, G. (2024). A prospective cohort study of factors associated with the digital cushion thickness in dairy cattle. Journal of Dairy Science, 107(9), 7230-7244. https://doi.org/10.3168/jds.2023-24563

Key factors such as stage of lactation, parity, and body fat reserves have been associated with the digital cushion thickness (DCT), however, there are discrepancies between the results of previously published studies. The objective of this study was... Read More about A prospective cohort study of factors associated with the digital cushion thickness in dairy cattle.

A Preliminary Study Assessing a Transfer Learning Approach to Intestinal Image Analysis to Help Determine Treatment Response in Canine Protein-Losing Enteropathy (2024)
Journal Article
Kathrani, A., Trewin, I., Ancheta, K., Psifidi, A., Le Calvez, S., & Williams, J. (in press). A Preliminary Study Assessing a Transfer Learning Approach to Intestinal Image Analysis to Help Determine Treatment Response in Canine Protein-Losing Enteropathy. Veterinary Sciences, 11(3), 129. https://doi.org/10.3390/vetsci11030129

Association between a genetic index for digital dermatitis resistance and the presence of digital dermatitis, heel horn erosion, and interdigital hyperplasia in Holstein cows (2024)
Journal Article
Anagnostopoulos, A., Barden, M., Griffiths, B., Bedford, C., Winters, M., Li, B., Coffey, M., Psifidi, A., Banos, G., & Oikonomou, G. (2024). Association between a genetic index for digital dermatitis resistance and the presence of digital dermatitis, heel horn erosion, and interdigital hyperplasia in Holstein cows. Journal of Dairy Science, 107(7), 4915-4925. https://doi.org/10.3168/jds.2023-24136

Digital dermatitis (DD) is a polybacterial disease endemic to most UK dairy farms. It poses a major financial and welfare threat and is characterized by high incidence and recurrence rates. We aimed to investigate the association between the UK EBV f... Read More about Association between a genetic index for digital dermatitis resistance and the presence of digital dermatitis, heel horn erosion, and interdigital hyperplasia in Holstein cows.

Chicken caecal enterotypes in indigenous Kadaknath and commercial Cobb chicken lines are associated with Campylobacter abundance and influenced by farming practices (2023)
Journal Article
Hay, M. C., Hinsu, A. T., Koringa, P. G., Pandit, R. J., Liu, P.-Y., Parekh, M. J., Jakhesara, S. J., Dai, X., Crotta, M., Fosso, B., Limon, G., Guitian, J., Tomley, F. M., Xia, D., Psifidi, A., Joshi, C. G., & Blake, D. P. (2023). Chicken caecal enterotypes in indigenous Kadaknath and commercial Cobb chicken lines are associated with Campylobacter abundance and influenced by farming practices. Frontiers in Microbiomes, https://doi.org/10.3389/frmbi.2023.1301609

Genetic characterisation of the Connemara pony and the Warmblood horse using a within-breed clustering approach (2023)
Journal Article
Lindsay-McGee, V., Sanchez-Molano, E., Banos, G., Clark, E., Piercy, R., & Psifidi, A. (2023). Genetic characterisation of the Connemara pony and the Warmblood horse using a within-breed clustering approach. Genetics Selection Evolution, 55(1), https://doi.org/10.1186/s12711-023-00827-w

BackgroundThe Connemara pony (CP) is an Irish breed that has experienced varied selection by breeders over the last fifty years, with objectives ranging from the traditional hardy pony to an agile athlete. We compared these ponies with well-studied W... Read More about Genetic characterisation of the Connemara pony and the Warmblood horse using a within-breed clustering approach.

Single-step genome-wide association analyses of claw horn lesions in Holstein cattle using linear and threshold models (2023)
Journal Article
Li, B., Barden, M., Kapsona, V., Sanchez-Molano, E., Anagnostopoulos, A., Griffiths, B., Bedford, C., Dai, X., Coffey, M., Psifidi, A., Oikonomou, G., & Banos, G. (2023). Single-step genome-wide association analyses of claw horn lesions in Holstein cattle using linear and threshold models. Genetics Selection Evolution, 55(1), https://doi.org/10.1186/s12711-023-00784-4

BackgroundLameness in dairy cattle is primarily caused by foot lesions including the claw horn lesions (CHL) of sole haemorrhage (SH), sole ulcers (SU), and white line disease (WL). This study investigated the genetic architecture of the three CHL ba... Read More about Single-step genome-wide association analyses of claw horn lesions in Holstein cattle using linear and threshold models.

Serum 1H nuclear magnetic resonance-based metabolomics of sole lesion development in Holstein cows (2023)
Journal Article
Barden, M., Phelan, M., Hyde, R., Anagnostopoulos, A., Griffiths, B., Bedford, C., Green, M., Psifidi, A., Banos, G., & Oikonomou, G. (2023). Serum 1H nuclear magnetic resonance-based metabolomics of sole lesion development in Holstein cows. Journal of Dairy Science, 106(4), 2667-2684. https://doi.org/10.3168/jds.2022-22681

those with the strongest evidence of being associated with sole lesions corresponded to phenylalanine and 4 unlabeled metabolites. We conclude that the serum metabolome, as characterized by proton nuclear magnetic resonance spectroscopy, does not app... Read More about Serum 1H nuclear magnetic resonance-based metabolomics of sole lesion development in Holstein cows.

Research Note: MHCY haplotype impacts Campylobacter jejuni colonization in a backcross [(Line 6(1) x Line N) x Line N] population (2022)
Journal Article
Zhang, J., Goto, R., Psifidi, A., Stevens, M., Taylor, R., & Miller, M. (2022). Research Note: MHCY haplotype impacts Campylobacter jejuni colonization in a backcross [(Line 6(1) x Line N) x Line N] population. Poultry Science, 101(3), https://doi.org/10.1016/j.psj.2021.101654

MHCY is a candidate region for influencing immune responses in chickens. MHCY contains multiple specialized, polymorphic MHC class I loci along with loci belonging to 4 additional gene families. In this study, MHCY haplotypes were tested for associat... Read More about Research Note: MHCY haplotype impacts Campylobacter jejuni colonization in a backcross [(Line 6(1) x Line N) x Line N] population.

Genetic parameters and genome-wide association study of digital cushion thickness in Holstein cows (2022)
Journal Article
Barden, M., Li, B., Griffiths, B., Anagnostopoulos, A., Bedford, C., Psifidi, A., Banos, G., & Oikonomou, G. (2022). Genetic parameters and genome-wide association study of digital cushion thickness in Holstein cows. Journal of Dairy Science, 105(10), 8237-8256. https://doi.org/10.3168/jds.2022-22035

The digital cushion is linked to the development of claw horn lesions (CHL) in dairy cattle. The objectives of this study were to (1) estimate genetic parameters for digital cushion thickness (DCT), (2) estimate the genetic correlation between DCT an... Read More about Genetic parameters and genome-wide association study of digital cushion thickness in Holstein cows.

Prospective cohort study of the association between early lactation mastitis and the presence of sole ulcers in dairy cows (2022)
Journal Article
Watson, C., Barden, M., Griffiths, B., Anagnostopoulos, A., Higgins, H., Bedford, C., Carter, S., Psifidi, A., Banos, G., & Oikonomou, G. (2022). Prospective cohort study of the association between early lactation mastitis and the presence of sole ulcers in dairy cows. Veterinary Record, https://doi.org/10.1002/vetr.1387

Background The objective of this study was to investigate the association between (sub)clinical mastitis (CM) in the first 30 days in milk (DIM) and the presence of sole ulcers (SU) later in lactation. Methods Holstein cows and heifers were examined... Read More about Prospective cohort study of the association between early lactation mastitis and the presence of sole ulcers in dairy cows.