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Chicken caecal enterotypes in indigenous Kadaknath and commercial Cobb chicken lines are associated with Campylobacter abundance and influenced by farming practices (2023)
Journal Article
Hay, M. C., Hinsu, A. T., Koringa, P. G., Pandit, R. J., Liu, P., Parekh, M. J., …Blake, D. P. (2023). Chicken caecal enterotypes in indigenous Kadaknath and commercial Cobb chicken lines are associated with Campylobacter abundance and influenced by farming practices. Frontiers in Microbiomes, https://doi.org/10.3389/frmbi.2023.1301609

Genetic characterisation of the Connemara pony and the Warmblood horse using a within-breed clustering approach (2023)
Journal Article
Lindsay-McGee, V., Sanchez-Molano, E., Banos, G., Clark, E., Piercy, R., & Psifidi, A. (2023). Genetic characterisation of the Connemara pony and the Warmblood horse using a within-breed clustering approach. Genetics Selection Evolution, 55(1), https://doi.org/10.1186/s12711-023-00827-w

BackgroundThe Connemara pony (CP) is an Irish breed that has experienced varied selection by breeders over the last fifty years, with objectives ranging from the traditional hardy pony to an agile athlete. We compared these ponies with well-studied W... Read More about Genetic characterisation of the Connemara pony and the Warmblood horse using a within-breed clustering approach.

Research Note: MHCY haplotype impacts Campylobacter jejuni colonization in a backcross [(Line 6(1) x Line N) x Line N] population (2022)
Journal Article
Zhang, J., Goto, R., Psifidi, A., Stevens, M., Taylor, R., & Miller, M. (2022). Research Note: MHCY haplotype impacts Campylobacter jejuni colonization in a backcross [(Line 6(1) x Line N) x Line N] population. Poultry Science, 101(3), https://doi.org/10.1016/j.psj.2021.101654

MHCY is a candidate region for influencing immune responses in chickens. MHCY contains multiple specialized, polymorphic MHC class I loci along with loci belonging to 4 additional gene families. In this study, MHCY haplotypes were tested for associat... Read More about Research Note: MHCY haplotype impacts Campylobacter jejuni colonization in a backcross [(Line 6(1) x Line N) x Line N] population.

Genetic parameters and genome-wide association study of digital cushion thickness in Holstein cows (2022)
Journal Article
Barden, M., Li, B., Griffiths, B., Anagnostopoulos, A., Bedford, C., Psifidi, A., …Oikonomou, G. (2022). Genetic parameters and genome-wide association study of digital cushion thickness in Holstein cows. Journal of Dairy Science, 105(10), 8237-8256. https://doi.org/10.3168/jds.2022-22035

The digital cushion is linked to the development of claw horn lesions (CHL) in dairy cattle. The objectives of this study were to (1) estimate genetic parameters for digital cushion thickness (DCT), (2) estimate the genetic correlation between DCT an... Read More about Genetic parameters and genome-wide association study of digital cushion thickness in Holstein cows.

Prospective cohort study of the association between early lactation mastitis and the presence of sole ulcers in dairy cows (2022)
Journal Article
Watson, C., Barden, M., Griffiths, B., Anagnostopoulos, A., Higgins, H., Bedford, C., …Oikonomou, G. (2022). Prospective cohort study of the association between early lactation mastitis and the presence of sole ulcers in dairy cows. Veterinary Record, https://doi.org/10.1002/vetr.1387

Background The objective of this study was to investigate the association between (sub)clinical mastitis (CM) in the first 30 days in milk (DIM) and the presence of sole ulcers (SU) later in lactation. Methods Holstein cows and heifers were examined... Read More about Prospective cohort study of the association between early lactation mastitis and the presence of sole ulcers in dairy cows.

Integrating Genetic and Genomic Analyses of Combined Health Data Across Ecotypes to Improve Disease Resistance in Indigenous African Chickens (2020)
Journal Article
Banos, G., Lindsay, V., Desta, T. T., Bettridge, J., Sanchez-Molano, E., Vallejo-Trujillo, A., …Psifidi, A. (2020). Integrating Genetic and Genomic Analyses of Combined Health Data Across Ecotypes to Improve Disease Resistance in Indigenous African Chickens. Frontiers in Genetics, 11, 543890

Poultry play an important role in the agriculture of many African countries. The majority of chickens in sub-Saharan Africa are indigenous, raised in villages under semi-scavenging conditions. Vaccinations and biosecurity measures rarely apply, and i... Read More about Integrating Genetic and Genomic Analyses of Combined Health Data Across Ecotypes to Improve Disease Resistance in Indigenous African Chickens.

Role of caecal microbiota in the differential resistance of inbred chicken lines to colonization by Campylobacter jejuni (2020)
Journal Article
Chintoan-Uta, C., Wisedchanwet, T., Glendinning, L., Bremner, A., Psifidi, A., Vervelde, L., …Stevens, M. P. (2020). Role of caecal microbiota in the differential resistance of inbred chicken lines to colonization by Campylobacter jejuni. Applied and Environmental Microbiology, https://doi.org/10.1128/AEM.02607-19

Campylobacter is the leading foodborne bacterial diarrhoeal illness in many countries, with up to 80 % of human cases attributed to the avian reservoir. The only control strategies currently available are stringent on-farm biosecurity and carcass tre... Read More about Role of caecal microbiota in the differential resistance of inbred chicken lines to colonization by Campylobacter jejuni.

The Genetic Architecture of Bovine Telomere Length in Early Life and Association With Animal Fitness (2019)
Journal Article
Ilska-Warner, J. J., Psifidi, A., Seeker, L. A., Wilbourn, R. V., Underwood, S. L., Fairlie, J., …Banos, G. (2019). The Genetic Architecture of Bovine Telomere Length in Early Life and Association With Animal Fitness. Frontiers in Genetics, 10, https://doi.org/10.3389/fgene.2019.01048

Health and survival are key goals for selective breeding in farm animals. Progress, however, is often limited by the low heritability of these animal fitness traits in addition to measurement difficulties. In this respect, relevant early-life biomark... Read More about The Genetic Architecture of Bovine Telomere Length in Early Life and Association With Animal Fitness.

Genome reconstruction of a novel carbohydrate digesting bacterium from the chicken caecal microflora (2019)
Journal Article
Hinsu, A. T., Pandit, R. J., Patel, S. H., Psifidi, A., Tomley, F. M., Das, S. K., …Joshi, C. G. (2019). Genome reconstruction of a novel carbohydrate digesting bacterium from the chicken caecal microflora. https://doi.org/10.1016/j.mgene.2019.01.002

The advent of metagenomics using Next-Generation Sequencing (NGS) has led to the acquisition of unprecedented quantities of bacterial sequence data. One use for these data is the recovery of complete genomes of uncultivable, and thus uncharacterised,... Read More about Genome reconstruction of a novel carbohydrate digesting bacterium from the chicken caecal microflora.

Colonization of a commercial broiler line by Campylobacter is under limited genetic control and does not significantly impair performance or intestinal health (2018)
Journal Article
Bailey, R. A., Kranis, A., Psifidi, A., Watson, K. A., Rothwell, L., Hocking, P. M., …Avendano, S. (2018). Colonization of a commercial broiler line by Campylobacter is under limited genetic control and does not significantly impair performance or intestinal health. Poultry Science, 97(12), 4167-4176. https://doi.org/10.3382/ps/pey295

Campylobacter is the leading bacterial cause of foodborne diarrheal illness in humans and source attribution studies unequivocally identify handling or consumption of poultry meat as a key risk factor. Campylobacter colonizes the avian intestines in... Read More about Colonization of a commercial broiler line by Campylobacter is under limited genetic control and does not significantly impair performance or intestinal health.

Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken (2018)
Journal Article
Boulton, K., Nolan, M. J., Wu, Z., Riggio, V., Matika, O., Harman, K., …Psifidi, A. (2018). Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken. Frontiers in Genetics, 9, https://doi.org/10.3389/fgene.2018.00528

Coccidiosis in poultry, caused by protozoan parasites of the genus Eimeria, is an intestinal disease with substantial economic impact. With the use of anticoccidial drugs under public and political pressure, and the comparatively higher cost of live-... Read More about Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken.

The role of local adaptation in sustainable production of village chickens (2018)
Journal Article
Bettridge, J. M., Psifidi, A., Terfa, Z. G., Desta, T. T., Lozano-Jaramillo, M., Dessie, T., …Christley, R. M. (2018). The role of local adaptation in sustainable production of village chickens. https://doi.org/10.1038/s41893-018-0150-9

Village chickens are ubiquitous in smallholder farming systems, contributing to household, local and national economies under diverse environmental, economic and cultural settings. However, they are raised in challenging environments where productivi... Read More about The role of local adaptation in sustainable production of village chickens.

Bovine telomere dynamics and the association between telomere length and productive lifespan (2018)
Journal Article
Seeker, L. A., Ilska, J. J., Psifidi, A., Wilbourn, R., Underwood, S., Fairlie, J., …Banos, G. (2018). Bovine telomere dynamics and the association between telomere length and productive lifespan. https://doi.org/10.1038/s41598-018-31185-z

Average telomere length (TL) in blood cells has been shown to decline with age in a range of vertebrate species, and there is evidence that TL is a heritable trait associated with late-life health and mortality in humans. In non-human mammals, few st... Read More about Bovine telomere dynamics and the association between telomere length and productive lifespan.