All Outputs (13)

Chronic idiopathic myopathy in Icelandic horses: A case series (2025)
Journal Article
Hansen, S., Hopster-Iversen, C., Berg, L., Fjeldborg, J., Massey, C., Piercy, R., & Carstensen, H. (2025). Chronic idiopathic myopathy in Icelandic horses: A case series. Equine Veterinary Journal, https://doi.org/10.1111/evj.14519

BackgroundExertional myopathies are recognised as a cause of poor performance in equines. In Icelandic horses presenting reduced performance and/or multi-limb lameness, no specific myopathy has been identified.ObjectivesTo characterise the clinical p... Read More about Chronic idiopathic myopathy in Icelandic horses: A case series.

Characterisation of phenotypic patterns in equine exercise-associated myopathies (2024)
Journal Article
Lindsay-McGee, V., Massey, C., Li, Y., Clark, E., Psifidi, A., & Piercy, R. (2024). Characterisation of phenotypic patterns in equine exercise-associated myopathies. Equine Veterinary Journal, https://doi.org/10.1111/evj.14128

Background Equine exercise-associated myopathies are prevalent, clinically heterogeneous, generally idiopathic disorders characterised by episodes of myofibre damage that occur in association with exercise. Episodes are intermittent and vary within a... Read More about Characterisation of phenotypic patterns in equine exercise-associated myopathies.

Locating a novel autosomal recessive genetic variant in the cattle glucokinase gene using only WGS data from three cases and six carriers (2022)
Journal Article
Pollott, G. E., Piercy, R. J., Massey, C., Salavati, M., Cheng, Z., & Wathes, D. C. (2022). Locating a novel autosomal recessive genetic variant in the cattle glucokinase gene using only WGS data from three cases and six carriers. Frontiers in Genetics, 13, 14. https://doi.org/10.3389/fgene.2022.755693

New Mendelian genetic conditions, which adversely affect livestock, arise all the time. To manage them effectively, some methods need to be devised that are quick and accurate. Until recently, finding the causal genomic site of a new autosomal recess... Read More about Locating a novel autosomal recessive genetic variant in the cattle glucokinase gene using only WGS data from three cases and six carriers.

A highly prevalent SINE mutation in the myostatin (MSTN) gene promoter is associated with low circulating myostatin concentration in Thoroughbred racehorses (2021)
Journal Article
O'Hara, V., Cowan, A., Riddell, D., Massey, C., Martin, J., & Piercy, R. (2021). A highly prevalent SINE mutation in the myostatin (MSTN) gene promoter is associated with low circulating myostatin concentration in Thoroughbred racehorses. Scientific Reports, 11(1), https://doi.org/10.1038/s41598-021-86783-1

Horse racing is a popular and financially important industry worldwide and researchers and horse owners are interested in genetic and training influences that maximise athletic performance. An association has been found between the presence of a shor... Read More about A highly prevalent SINE mutation in the myostatin (MSTN) gene promoter is associated with low circulating myostatin concentration in Thoroughbred racehorses.

VCF Files (2021)
Data
Pollott, G., Wathes, D. C., Piercy, R., Massey, C., Salavati, M., & Cheng, Z. VCF Files. [Data]

Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy (2018)
Journal Article
Amoasii, L., Hildyard, J. C. W., Li, H., Sanchez-Ortiz, E., Mireault, A., Caballero, D., Harron, R., Stathopoulou, T.-R., Massey, C. A., Shelton, J. M., Bassel-Duby, R., Piercy, R. J., & Olson, E. N. (2018). Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Science, 362(6410), 86-91. https://doi.org/10.1126/science.aau1549

Mutations in the gene encoding dystrophin, a protein that maintains muscle integrity and function, cause Duchenne muscular dystrophy (DMD). The deltaE50-MD dog model of DMD harbors a mutation corresponding to a mutational “hotspot” in the human DMD g... Read More about Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy.

Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy
Journal Article
Hildyard, J. C. W., Taylor-Brown, F. E., Massey, C., Wells, D. J., & Piercy, R. J. (in press). Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy. Journal of Neuromuscular Diseases, 5(2), 177-191. https://doi.org/10.3233/JND-170267

Background:Dogs with dystrophin-deficient muscular dystrophy are valuable models of the equivalent human disease, Duchenne Muscular Dystrophy (DMD): unlike the mdx mouse, these animals present a disease severity and progression that closely matches t... Read More about Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy.

CHARACTERISING THE SKELETAL MUSCLE HISTOLOGICAL PHENOTYPE OF THE DELTAE50-MD DOG, A PRECLINICAL MODEL OF DUCHENNE MUSCULAR DYSTROPHY
Presentation / Conference Contribution
Hildyard, J. C. W., Rawson, F., Harron, R., Riddell, D., Massey, C. A., Taylor-Brown, F. E., Wells, D. J., & Piercy, R. J. CHARACTERISING THE SKELETAL MUSCLE HISTOLOGICAL PHENOTYPE OF THE DELTAE50-MD DOG, A PRECLINICAL MODEL OF DUCHENNE MUSCULAR DYSTROPHY

Severe Systemic Calciphylaxis in a Young Cat
Journal Article
Anfinsen, K. P., Piercy, R. J., Massey, C. A., Smith, K. C., Kenny, P. J., & Garden, O. A. (in press). Severe Systemic Calciphylaxis in a Young Cat. Journal of Veterinary Internal Medicine, 28(4), 1325-30. https://doi.org/10.1111/jvim.12378

Vacuolar myopathy in an adult Warmblood horse
Journal Article
Massey, C. A., Walmsley, G. L., Gliddon, T. P., & Piercy, R. J. Vacuolar myopathy in an adult Warmblood horse. Neuromuscular Disorders, 23(6), 473-477. https://doi.org/10.1016/j.nmd.2013.03.007

Allele Copy Number and Underlying Pathology Are Associated with Subclinical Severity in Equine Type 1 Polysaccharide Storage Myopathy (PSSM1)
Journal Article
Naylor, R. J., Livesey, L., Schumacher, J., Henke, N., Massey, C. A., Brock, K. V., Fernandez-Fuente, M., & Piercy, R. J. (in press). Allele Copy Number and Underlying Pathology Are Associated with Subclinical Severity in Equine Type 1 Polysaccharide Storage Myopathy (PSSM1). PLoS ONE, 7(7), e42317. https://doi.org/10.1371/journal.pone.0042317

Equine type 1 polysaccharide storage myopathy (PSSM1), a common glycogenosis associated with an R309H founder mutation in the glycogen synthase 1 gene (GYS1), shares pathological features with several human myopathies. In common with related human di... Read More about Allele Copy Number and Underlying Pathology Are Associated with Subclinical Severity in Equine Type 1 Polysaccharide Storage Myopathy (PSSM1).

INFLUENCE OF ALLELE COPY NUMBER ON SKELETAL MUSCLE HISTOPATHOLOGY IN HORSES WITH TYPE 1 POLYSACCHARIDE STORAGE MYOPATHY
Presentation / Conference Contribution
Naylor, R. J., Johnstone, S., Livesey, L., Schumacher, J., Fuentes, V. L., Massey, C. A., Henke, N., Fernandez-Fuente, M., Brock, K., & Piercy, R. J. INFLUENCE OF ALLELE COPY NUMBER ON SKELETAL MUSCLE HISTOPATHOLOGY IN HORSES WITH TYPE 1 POLYSACCHARIDE STORAGE MYOPATHY

Epidemiology of Exertional Rhabdomyolysis Susceptibility in Standardbred Horses Reveals Associated Risk Factors and Underlying Enhanced Performance
Journal Article
Isgren, C. M., Upjohn, M. J., Fernandez-Fuente, M., Massey, C. A., Pollott, G. E., Verheyen, K. L. P., & Piercy, R. J. Epidemiology of Exertional Rhabdomyolysis Susceptibility in Standardbred Horses Reveals Associated Risk Factors and Underlying Enhanced Performance. PLoS ONE, 5(7), e11594. https://doi.org/10.1371/journal.pone.0011594