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All Outputs (35)

International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus (2025)
Journal Article
Short, E., Huckstepp, R., Alavian, K., Amoaku, W., Barber, T., van Beek, E., Benbow, E., Bhandari, S., Bloom, P., Cota, C., Chazot, P., Christopher, G., Demaria, M., Erusalimsky, J., Ferenbach, D., Foster, T., Gazzard, G., Glassock, R., Jamal, N., Kalaria, R., …Bentley, B. (2025). International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus. GeroScience, https://doi.org/10.1007/s11357-025-01509-9

Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185 (2018)
Journal Article
Holder, A. L., Jones, G., Soutter, F., Palmer, D. B., Aspinall, R., & Catchpole, B. (2018). Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185. Developmental and Comparative Immunology, 81, 244-251. https://doi.org/10.1016/j.dci.2017.12.008

Interleukin-7 (IL-7) and its receptor (IL-7R) are essential for T cell development in the thymus, and changes in the IL-7/IL-7R pathway have been implicated in age-associated thymic involution which results in a reduction of naïve T cell output. The... Read More about Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185.

An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity (2016)
Journal Article
Holder, A., Mella, S., Palmer, D. B., Aspinall, R., & Catchpole, B. (2016). An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity. PLoS ONE, 11, e0165968. https://doi.org/10.1371/journal.pone.0165968

The age associated decline in immune function is preceded in mammals by a reduction in thymic output. Furthermore, there is increasing evidence of a link between immune competence and lifespan. One approach to determining thymic output is to quantify... Read More about An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity.

Disorganization of the splenic microanatomy in ageing mice (2016)
Journal Article
Aw, D. P. S., Hilliard, L., Nishikawa, Y., Cadman, E. T., Lawrence, R. A., & Palmer, D. B. (2016). Disorganization of the splenic microanatomy in ageing mice. Immunology, 148(1), 92-101. https://doi.org/10.1111/imm.12590

The precise mechanisms responsible for immunosenescence still remain to be determined, however, considering the evidence that disruption of the organization of primary and secondary lymphoid organs results in immunodeficiency, we propose that this co... Read More about Disorganization of the splenic microanatomy in ageing mice.

The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice (2016)
Journal Article
Heppolette, C. A. A., Chen, J.-H., Carr, S. K., Palmer, D. B., & Ozanne, S. E. (2016). The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice. Oncotarget, 7(6), 6398-6409. https://doi.org/10.18632/oncotarget.7176

Environmental factors such as nutrition during early life can influence long-term health, a concept termed developmental programming. Initial research was focused towards the effects on metabolic health but more recent studies have demonstrated effec... Read More about The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice.

Architectural changes in the thymus of aging mice
Journal Article
Aw, D. P. S., Silva, A. B., Maddick, M., von Zglinicki, T., & Palmer, D. B. Architectural changes in the thymus of aging mice. Aging Cell, 7(2), 158-167. https://doi.org/10.1111/j.1474-9726.2007.00365.x

Age-associated thymic involution is one of the most dramatic and ubiquitous changes in the immune system, although the precise mechanisms involved still remain obscured. Several hypotheses have been proposed incorporating extrinsic and intrinsic fact... Read More about Architectural changes in the thymus of aging mice.

Neuropeptides and thymic hormones in the Xenopus thymus
Journal Article
Silva, A. B., Aw, D. P. S., & Palmer, D. B. Neuropeptides and thymic hormones in the Xenopus thymus. Frontiers in Bioscience, 14, 1990-2003. https://doi.org/10.2741/3358

T-cell development is characterised by a complex series of events in the thymus, which results in the development of self-restricted immunocompetent lymphocytes. We have previously reported the expression of neuropeptides in the thymus of various spe... Read More about Neuropeptides and thymic hormones in the Xenopus thymus.