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Immunohistochemical characterization of normal feline adrenal tissue and adrenal tumors secreting aldosterone (2025)
Journal Article
Watson, A., Allan, F., Harrington, N., Mahony, O., Brown, M., & Syme, H. (2025). Immunohistochemical characterization of normal feline adrenal tissue and adrenal tumors secreting aldosterone. Veterinary Pathology, https://doi.org/10.1177/03009858251331146

It is suggested that primary hyperaldosteronism (PHA) is an under-diagnosed cause of systemic hypertension in cats. No immunohistochemical markers of aldosterone synthesizing tissues have been identified, meaning that endocrine function cannot be inf... Read More about Immunohistochemical characterization of normal feline adrenal tissue and adrenal tumors secreting aldosterone.

Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors (2024)
Journal Article
Watson, A., Syme, H., & Brown, M. (2024). Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors. Hypertension, 81(12), 2489-2500. https://doi.org/10.1161/HYPERTENSIONAHA.124.23501

BACKGROUND:Primary aldosteronism (PA) is a common cause of human hypertension. Somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 are found in at least 80% of aldosterone-producing adenomas, which cause unilateral PA in humans. Somatic mutations... Read More about Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors.

Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors (2024)
Journal Article
Allan, F., Watson, A., & Syme, H. (2024). Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17212

Background: Functionality of human adrenal tumors is inferred by CYP11B1 (cortisol synthase) expression, CYP11B2 (aldosterone synthase) expression, or both. Hypothesis/Objectives: Nonfunctional canine adrenal tumors have low expression of steroidogen... Read More about Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors.

Thirty-two cats with effusive or non-effusive feline infectious peritonitis treated with a combination of remdesivir and GS-441524 (2023)
Journal Article
Green, J., Syme, H., & Tayler, S. (2023). Thirty-two cats with effusive or non-effusive feline infectious peritonitis treated with a combination of remdesivir and GS-441524. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16804

BackgroundGS-441524 has been successfully used to treat feline infectious peritonitis (FIP) in cats. However, the use of its prodrug, remdesivir, in combination with a PO GS-441524 containing product for the treatment of FIP has not yet been describe... Read More about Thirty-two cats with effusive or non-effusive feline infectious peritonitis treated with a combination of remdesivir and GS-441524.

Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom (2023)
Journal Article
Geddes, R. F., Davison, L. J., Elliott, J., Syme, H. M., & O'Neill, D. G. (2023). Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom. Journal of Veterinary Internal Medicine, 37(2), 567-577. https://doi.org/10.1111/jvim.16659

Background
Cats presenting with upper urinary tract uroliths (UUTUs) and ureteral obstruction (“obstructive UUTU”) are typically younger than cats with idiopathic CKD that often have incidental nephroliths.

Hypothesis
Cats with upper urinary tra... Read More about Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom.

Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019) (2023)
Journal Article
Broughton, S. E., O'Neill, D. G., Syme, H. M., & Geddes, R. F. (in press). Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019). Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16627

Background
Ionized calcium concentration ([iCa]) is more sensitive for detecting calcium disturbances than serum total calcium concentration but literature on ionized hypercalcemia in cats is limited. Urolithiasis is a possible adverse consequence o... Read More about Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019).

First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats (2022)
Journal Article
Jepson, R. E., Warren, H., Syme, H. M., Elliott, J., & Munroe, P. B. (2022). First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats. Scientific Reports, https://doi.org/10.1038/s41598-022-05494-3

Hypertension (HTN) and chronic kidney disease (CKD) are common in ageing cats. In humans, blood pressure (BP) and renal function are complex heritable traits. We performed the first feline Genome-Wide Association Study (GWAS) of quantitative traits s... Read More about First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats.

Treatment failure in hyperthyroid cats after radioiodine (I-131) injection (2021)
Journal Article
Mullowney, D., Chang, Y., Glanemann, B., & Syme, H. (2021). Treatment failure in hyperthyroid cats after radioiodine (I-131) injection. Journal of Veterinary Internal Medicine, 35(4), 1688-1696. https://doi.org/10.1111/jvim.16161

Background There is limited published information on the outcome for cats where total thyroxine concentration (TT4) remains elevated after treatment with radioactive iodine (RAI). Objective To determine the frequency of, and predictors for, subsequen... Read More about Treatment failure in hyperthyroid cats after radioiodine (I-131) injection.

Changes in retinal vascular diameters in senior and geriatric cats in association with variation in systemic blood pressure (2021)
Journal Article
Enache, A., Dietrich, U., Drury, O., Trucco, E., MacGillivray, T., Syme, H., Elliott, J., & Chang, Y.-M. (2021). Changes in retinal vascular diameters in senior and geriatric cats in association with variation in systemic blood pressure. Journal of Feline Medicine and Surgery,

Objectives Early diagnosis of arterial hypertension is essential to prevent target organ damage. In humans, retinal arteriolar narrowing predicts hypertension. This blinded prospective observational study investigated the retinal vessel diameters amo... Read More about Changes in retinal vascular diameters in senior and geriatric cats in association with variation in systemic blood pressure.

Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease (2020)
Journal Article
Lawson, J., Syme, H., Wheeler-Jones, C., & Elliott, J. (2020). Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease. The Veterinary Journal, 267, 105582. https://doi.org/10.1016/j.tvjl.2020.105582

Chronic kidney disease (CKD) is common in geriatric cats, and is characterised in the majority of cases by tubulointerstitial inflammation and fibrosis. Hyperphosphataemia is a frequent complication of CKD and is independently associated with severit... Read More about Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease.

Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype (2019)
Journal Article
Lawson, J. S., Syme, H. M., Wheeler-Jones, C. P. D., & Elliott, J. (2019). Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype. Research in Veterinary Science, 127, 99-102. https://doi.org/10.1016/j.rvsc.2019.10.012

The Crandell-Rees Feline Kidney Cell (CRFK) is an immortalised cell line derived from the feline kidney that is utilised for the growth of certain vaccinal viruses. Confusion exists as to whether CRFK are epithelial or mesenchymal in phenotype. The a... Read More about Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype.

Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs (2019)
Journal Article
Pelander, L., Brunchault, V., Buffin-Meyer, B., Klein, J., Breuil, B., Zürbig, P., Magalhães, P., Mullen, W., Elliott, J., Syme, H. M., Schanstra, J. P., Häggström, J., & Ljungvall, I. (2019). Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs. https://doi.org/10.1016/j.tvjl.2019.05.010

Chronic kidney disease (CKD) is clinically important in canine medicine. Current diagnostic tools lack sensitivity for detection of subclinical CKD. The aim of the present study was to evaluate urinary peptidome analysis for diagnosis of CKD in dogs.... Read More about Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs.

Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dogs (2019)
Journal Article
Pelander, L., Häggström, J., Larsson, A., Syme, H. M., Elliott, J., Heiene, R., & Ljungvall, I. (2019). Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dogs. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15445

ACVIM consensus statement: Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats (2018)
Journal Article
Acierno, M. J., Brown, S., Coleman, A. E., Jepson, R. E., Papich, M., Stepien, R. L., & Syme, H. M. (2018). ACVIM consensus statement: Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15331

An update to the 2007 American College of Veterinary Internal Medicine (ACVIM) consensus statement on the identification, evaluation, and management of systemic hypertension in dogs and cats was presented at the 2017 ACVIM Forum in National Harbor, M... Read More about ACVIM consensus statement: Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats.

The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1 (2018)
Journal Article
Lawson, J. S., Liu, H.-H., Syme, H. M., Purcell, R., Wheeler-Jones, C. P. D., & Elliott, J. (2018). The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1. PLoS ONE, 13(8), e0202577. https://doi.org/10.1371/journal.pone.0202577

Chronic kidney disease (CKD) is common in both geriatric cats and aging humans, and is pathologically characterised by chronic tubulointerstitial inflammation and fibrosis in both species. Cats with CKD may represent a spontaneously occurring, non-ro... Read More about The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1.

Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1 (2018)
Journal Article
Lawson, J. S., Syme, H. M., Wheeler-Jones, C. P. D., & Elliott, J. (2018). Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1. BMC Veterinary Research, 14, 76. https://doi.org/10.1186/s12917-018-1387-2

Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell type predominantly responsible for the production of extra-cellular matrix in renal fibrosis... Read More about Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1.

Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats (2018)
Journal Article
Geddes, R. F., Jepson, R. E., Forcada, Y., Elliott, J., & Syme, H. M. (2018). Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats. https://doi.org/10.1016/j.tvjl.2018.02.010

Feline chronic kidney disease (CKD) is associated with high variability in severity of CKD-mineral and bone disorder (CKD-MBD). The calcium sensing receptor (CaSR) regulates circulating parathyroid hormone (PTH) and calcium concentrations. Single nuc... Read More about Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats.