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Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target? (2024)
Journal Article
Ritson, M., Wheeler-Jones, C. P., & Stolp, H. B. (2024). Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?. Journal of Neuroimmunology, 391, 578363. https://doi.org/10.1016/j.jneuroim.2024.578363

Neurological diseases with a neurodegenerative component have been associated with alterations in the cerebrovasculature. At the anatomical level, these are centred around changes in cerebral blood flow and vessel organisation. At the molecular level... Read More about Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?.

Developmental priming of early cerebrovascular ageing: Implications across a lifetime (2024)
Journal Article
Stolp, H. B., & Solito, E. (2024). Developmental priming of early cerebrovascular ageing: Implications across a lifetime. International Journal of Geriatric Psychiatry, 39(4), https://doi.org/10.1002/gps.6090

Introduction
Neurological conditions such as Alzheimer's disease and stroke represent a substantial health burden to the world's ageing population. Cerebrovascular dysfunction is a key contributor to these conditions, affecting an individual's risk... Read More about Developmental priming of early cerebrovascular ageing: Implications across a lifetime.

Sex-Specific Behavioural Deficits in Adulthood following Acute Activation of the GABA<sub>A</sub> Receptor in the Neonatal Mouse (2024)
Journal Article
Goikolea-Vives, A., Fernandes, C., Thomas, M. S., Thornton, C., & Stolp, H. B. (in press). Sex-Specific Behavioural Deficits in Adulthood following Acute Activation of the GABAA Receptor in the Neonatal Mouse. Developmental Neuroscience, 1-15. https://doi.org/10.1159/000536641

Introduction: Sex differences exist in the prevalence of neurodevelopmental disorders (NDDs). Part of the aetiology of NDDs has been proposed to be alterations in the balance between excitatory and inhibitory neurotransmission, leading to the questio... Read More about Sex-Specific Behavioural Deficits in Adulthood following Acute Activation of the GABA<sub>A</sub> Receptor in the Neonatal Mouse.

Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity (2022)
Journal Article
Yates, A., Kislitsyna, E., Alfonso Martin, C., Zhang, J., Sewell, A., Goikolea-Vives, A., Cai, V., Alkhader, L., Saland, A., Hammond, B., Dimitrova, R., Batalle, D., Fernandes, C., Edwards, A. D., Gressens, P., Thornton, C., & Stolp, H. (in press). Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity. Journal of Neuroinflammation, https://doi.org/10.1186/s12974-022-02625-5

Encephalopathy of prematurity (EoP) affects approximately 30% of infants born <32 weeks gestation and is highly associated with inflammation in the foetus. Here we evaluated the efficacy of Montelukast, a cysteinyl leukotriene receptor antagonist wid...

The molecular anatomy and functions of the choroid plexus in healthy and diseased brain (2020)
Journal Article
Kratzer, I., Ek, J., & Stolp, H. (2020). The molecular anatomy and functions of the choroid plexus in healthy and diseased brain. BBA - Biomembranes, 1862(11), 183430. https://doi.org/10.1016/j.bbamem.2020.183430

The choroid plexus (CP) is located in the ventricular system of the brain (one in each ventricle), and the CP epithelial cells form an important barrier between the blood and the cerebrospinal fluid (CSF). Their main function comprises CSF secretion,... Read More about The molecular anatomy and functions of the choroid plexus in healthy and diseased brain.

Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders (2020)
Journal Article
Fleiss, B., Gressens, P., & Stolp, H. B. (2020). Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders. Frontiers in Neurology, 11, https://doi.org/10.3389/fneur.2020.00575

Preterm-born infants frequently suffer from an array of neurological damage, collectively termed encephalopathy of prematurity (EoP). They also have an increased risk of presenting with a neurodevelopmental disorder (e.g., autism spectrum disorder; a... Read More about Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders.

TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex (2019)
Journal Article
Yli-Karjanmaa, M., Larsen, K. S., Fenger, C. D., Kellemann Kristensen, L., Martin, N. A., Jensen, P. T., Breton, A., Nathanson, L., Nielsen, P. V., Lund, M. C., Lindeman Carlsen, S., Gramsbergen, J. B., Finsen, B., Stubbe, J., Frich, L. H., Stolp, H. B., Brambilla, R., Anthony, D. C., Meyer, M., & Lambertsen, K. L. (2019). TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex. Brain, Behavior, and Immunity, 82, 279-297. https://doi.org/10.1016/j.bbi.2019.08.195

Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human (2019)
Journal Article
Stolp, H. B., Fleiss, B., Arai, Y., Supramaniam, V., Vontell, R., Birtles, S., Yates, A., Baburamani, A. A., Thornton, C., Rutherford, M., Edwards, A. D., & Gressens, P. (2019). Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human. Frontiers in Physiology, 10(955), https://doi.org/10.3389/fphys.2019.00955

Preterm brain injury, occurring in approximately 30% of infants born

Zika virus impairs the development of blood vessels in a mouse model of congenital infection (2018)
Journal Article
Garcez, P. P., Stolp, H. B., Sravanam, S., Christoff, R. R., Ferreira, J. C. C. G., Dias, A. A., Pezzuto, P., Higa, L. M., Barbeito-Andrés, J., Ferreira, R. O., Andrade, C. B. V., Siqueira, M., Santos, T. M. P., Drumond, J., Hoerder-Suabedissen, A., De Lima, C. V. F., Tovar-Moll, F., Lopes, R. T., Fragel-Madeira, L., Lent, R., …Molnár, Z. (2018). Zika virus impairs the development of blood vessels in a mouse model of congenital infection. https://doi.org/10.1038/s41598-018-31149-3

Zika virus (ZIKV) is associated with brain development abnormalities such as primary microcephaly, a severe reduction in brain growth. Here we demonstrated in vivo the impact of congenital ZIKV infection in blood vessel development, a crucial step in... Read More about Zika virus impairs the development of blood vessels in a mouse model of congenital infection.

Voxel-wise comparisons of cellular microstructure and diffusion-MRI in mouse hippocampus using 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND) (2018)
Journal Article
Stolp, H. B., Ball, G., So, P.-W., Tournier, J.-D., Jones, M., Thornton, C., & Edwards, A. D. (2018). Voxel-wise comparisons of cellular microstructure and diffusion-MRI in mouse hippocampus using 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND). https://doi.org/10.1038/s41598-018-22295-9

A key challenge in medical imaging is determining a precise correspondence between image properties and tissue microstructure. This comparison is hindered by disparate scales and resolutions between medical imaging and histology. We present a new tec... Read More about Voxel-wise comparisons of cellular microstructure and diffusion-MRI in mouse hippocampus using 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND).

Hepatic acute phase response protects the brain from focal inflammation during postnatal window of susceptibility (2018)
Journal Article
Sá-Pereira, I., Roodselaar, J., Couch, Y., Consentino Kronka Sosthenes, M., Evans, M. C., Anthony, D. C., & Stolp, H. B. (2018). Hepatic acute phase response protects the brain from focal inflammation during postnatal window of susceptibility. Brain, Behavior, and Immunity, https://doi.org/10.1016/j.bbi.2018.01.008

Perinatal inflammation is known to contribute to neurodevelopmental diseases. Animal models of perinatal inflammation have revealed that the inflammatory response within the brain is age dependent, but the regulators of this variation remain unclear.... Read More about Hepatic acute phase response protects the brain from focal inflammation during postnatal window of susceptibility.

STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression (2014)
Journal Article
Turnquist, C., Wang, Y., Severson, D. T., Zhong, S., Sun, B., Ma, J., Constaninescu, S. N., Ansorge, O., Stolp, H. B., Molnár, Z., Szele, F. G., & Lu, X. (2014). STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression. https://doi.org/10.1073/pnas.1407898111

Inflammation and loss of cell polarity play pivotal roles in neurodegeneration and cancer. A central question in both diseases is how the loss of cell polarity is sensed by cell death machinery. Here, we identify apoptosis-stimulating protein of p53... Read More about STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression.

CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis (2014)
Journal Article
Evans, M. C., Gaillard, P. J., De Boer, M., Appeldoorn, C., Dorland, R., Sibson, N. R., Turner, M. R., Anthony, D. C., & Stolp, H. B. (2014). CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis. Acta Neuropathologica Communications, 2, 66. https://doi.org/10.1186/2051-5960-2-66

Hallmarks of CNS inflammation, including microglial and astrocyte activation, are prominent features in post-mortem tissue from amyotrophic lateral sclerosis (ALS) patients and in mice overexpressing mutant superoxide dismutase-1 (SOD1 G93A ). Admini... Read More about CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis.