FIBRILLIN-1 EXPRESSION, WHICH REGULATES OF TGF-B BIOAVAILABILITY, IS MODIFIED DURING OSTEOARTHRITIS AND MUTATIONS LEAD TO OSTEOARTHRITIS
Journal Article
Ramanayake, W., Jones, H., Orriss, I. R., Arnett, T., Pitsillides, A. A., Denton, C., Abraham, D., & Poulet, B. FIBRILLIN-1 EXPRESSION, WHICH REGULATES OF TGF-B BIOAVAILABILITY, IS MODIFIED DURING OSTEOARTHRITIS AND MUTATIONS LEAD TO OSTEOARTHRITIS
All Outputs (50)
THE REGULATION OF SKELETAL AND SOFT TISSUE MINERALIZATION BY ATP AND NPP1
Presentation / Conference Contribution
Orriss, I. R., Hajjawi, M. O. R., & Arnett, T. R. THE REGULATION OF SKELETAL AND SOFT TISSUE MINERALIZATION BY ATP AND NPP1
Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures
Journal Article
Wornham, D. P., Hajjawi, M. O. R., Orriss, I. R., & Arnett, T. R. (in press). Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures. Osteoporosis International, 25(10), 2477-2484. https://doi.org/10.1007/s00198-014-2791-5The basic mechanisms by which strontium ranelate acts on bone are still unclear. We show that an important action of strontium salts is to block calcification in cultures of osteoblasts, the bone-forming cells. These results suggest that strontium tr... Read More about Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures.
Optimisation of the differing conditions required for bone formation in vitro by primary osteoblasts from mice and rats
Journal Article
Orriss, I. R., Hajjawi, M. O. R., Huesa, C., MacRae, V. E., & Arnett, T. R. (in press). Optimisation of the differing conditions required for bone formation in vitro by primary osteoblasts from mice and rats. International Journal of Molecular Medicine, 34(5), 1201-1208. https://doi.org/10.3892/ijmm.2014.1926The in vitro culture of calvarial osteoblasts from neonatal rodents remains an important method for studying the regulation of bone formation. The widespread use of transgenic mice has created a particular need for a reliable, simple method that allo... Read More about Optimisation of the differing conditions required for bone formation in vitro by primary osteoblasts from mice and rats.
Strontium and osteoblast function
Journal Article
Wornham, D., Hajjawi, M. O. R., Orriss, I. R., & Arnett, T. R. Strontium and osteoblast function. Osteoporosis International, https://doi.org/10.1007/s00198-015-3120-3
FIBRILLIN-1 IS EXPRESSED IN CARTILAGE AND MUTATION LEADS TO OA DEVELOPMENT
Presentation / Conference Contribution
Ramanayake, W., Jones, H., Orriss, I. R., Arnett, T., Pitsillides, A. A., Denton, C., Abraham, D., & Poulet, B. FIBRILLIN-1 IS EXPRESSED IN CARTILAGE AND MUTATION LEADS TO OA DEVELOPMENT
The role of purinergic signalling in the musculoskeletal system
Journal Article
Orriss, I. R. (in press). The role of purinergic signalling in the musculoskeletal system. https://doi.org/10.1016/j.autneu.2015.04.013
Allopurinol and oxypurinol promote osteoblast differentiation and increase bone formation
Journal Article
Orriss, I. R., Arnett, T. R., George, J., & Witham, M. D. (in press). Allopurinol and oxypurinol promote osteoblast differentiation and increase bone formation. Experimental Cell Research, 342(2), 166-174. https://doi.org/10.1016/j.yexcr.2016.03.004
Design and fabrication of 3D-printed anatomically shaped lumbar cage for intervertebra disc (IVD) degeneration treatment
Journal Article
Serra, T., Capelli, C., Toumpaniari, R., Orriss, I. R., Leong, J., Dalgarno, K., & Kalaskar, D. (in press). Design and fabrication of 3D-printed anatomically shaped lumbar cage for intervertebra disc (IVD) degeneration treatment. Biofabrication, 8(3), https://doi.org/10.1088/1758-5090/8/3/035001
Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice
Journal Article
Orriss, I. R., Lanham, S. A., Savery, D., Greene, N. D. E., Stanier, P., Oreffo, R., Copp, A. J., & Galea, G. L. (in press). Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice. https://doi.org/10.1038/s41598-018-21718-xFractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently determines bone mass... Read More about Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.