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Sodium glucose transporter 2 inhibitors: Will these drugs benefit non-diabetic veterinary patients with cardiac and kidney diseases? (2024)
Journal Article
Elliott, J., & Oyama, M. A. (2024). Sodium glucose transporter 2 inhibitors: Will these drugs benefit non-diabetic veterinary patients with cardiac and kidney diseases?. Journal of Veterinary Pharmacology and Therapeutics, n/a(n/a), https://doi.org/10.1111/jvp.13472

Abstract Sodium glucose transporter type 2 (SGLT2) inhibitors have been introduced into human medicine where their beneficial effects go beyond the expected improvement in blood glucose control. These drugs appear to prevent progression of both cardi... Read More about Sodium glucose transporter 2 inhibitors: Will these drugs benefit non-diabetic veterinary patients with cardiac and kidney diseases?.

Dietary magnesium supplementation in cats with chronic kidney disease: A prospective double-blind randomized controlled trial (2024)
Journal Article
Tang, P., van den Broek, D., Jepson, R., Geddes, R., Chang, Y., Loetter, N., Moniot, D., Biourge, V., & Elliott, J. (2024). Dietary magnesium supplementation in cats with chronic kidney disease: A prospective double-blind randomized controlled trial. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17134

Background: Plasma total magnesium concentration (tMg) is a prognostic indicator in cats with chronic kidney disease (CKD), shorter survival time being associated with hypomagnesemia. Whether this risk factor is modifiable with dietary magnesium supp... Read More about Dietary magnesium supplementation in cats with chronic kidney disease: A prospective double-blind randomized controlled trial.

Risk factors and implications associated with ultrasound-diagnosed nephrocalcinosis in cats with chronic kidney disease (2024)
Journal Article
Tang, P.-K., Geddes, R. F., Chang, Y.-M., Jepson, R. E., Van Den Broek, D. H. N., Lötter, N., & Elliott, J. (in press). Risk factors and implications associated with ultrasound-diagnosed nephrocalcinosis in cats with chronic kidney disease. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17034

Background: Microscopic nephrocalcinosis is a common pathological feature of

Detection of nephrocalcinosis using ultrasonography, micro-computed tomography, and histopathology in cats (2024)
Journal Article
Tang, P., Geddes, R., Chang, Y., Jepson, R., van den Broek, D., Lötter, N., & Elliott, J. (2024). Detection of nephrocalcinosis using ultrasonography, micro-computed tomography, and histopathology in cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17011

BackgroundIdentification of nephrocalcinosis in cats with chronic kidney disease (CKD) is of clinical interest but the ability of ultrasonography to detect nephrocalcinosis is uncertain.ObjectivesTo compare ultrasonography, micro-computed tomography... Read More about Detection of nephrocalcinosis using ultrasonography, micro-computed tomography, and histopathology in cats.

Effect of timing of pre-emptive administration of meloxicam and robenacoxib for feline ovariectomy on perioperative renal homeostasis, clotting function and perioperative analgesia; a randomised, blinded, controlled clinical trial (2024)
Journal Article
Krekis, A., King, J. N., D'Arcy-Howard, D., Stapleton, N., Elliott, J., & Pelligand, L. (in press). Effect of timing of pre-emptive administration of meloxicam and robenacoxib for feline ovariectomy on perioperative renal homeostasis, clotting function and perioperative analgesia; a randomised, blinded, controlled clinical trial. Veterinary Anaesthesia and Analgesia, https://doi.org/10.1111/jvp.13427

Please find attached our paper for review entitled 'Effect of timing of pre-emptive 12 administration of meloxicam and robenacoxib for feline ovariectomy on perioperative renal 13 homeostasis, clotting function and perioperative analgesia; a randomis... Read More about Effect of timing of pre-emptive administration of meloxicam and robenacoxib for feline ovariectomy on perioperative renal homeostasis, clotting function and perioperative analgesia; a randomised, blinded, controlled clinical trial.

Effect of meloxicam or robenacoxib administration timing on renal function and postoperative analgesia in cats undergoing ovariohysterectomy: A randomized, blinded, controlled clinical trial (2024)
Journal Article
Krekis, A., King, J., D'Arcy-Howard, D., Stapleton, N., Elliott, J., & Pelligand, L. (2024). Effect of meloxicam or robenacoxib administration timing on renal function and postoperative analgesia in cats undergoing ovariohysterectomy: A randomized, blinded, controlled clinical trial. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13427

We evaluated the effect of administration timing of meloxicam and robenacoxib on renal function, platelet cyclo-oxygenase and perioperative analgesia in 60 cats undergoing ovariohysterectomy, in a prospective randomized blinded controlled study. Twel... Read More about Effect of meloxicam or robenacoxib administration timing on renal function and postoperative analgesia in cats undergoing ovariohysterectomy: A randomized, blinded, controlled clinical trial.

Short-term induced hyperinsulinaemia and dexamethasone challenge do not affect circulating total adiponectin concentrations in insulin-sensitive ponies (2023)
Journal Article
Barnabé, M., Elliott, J., Harris, P., & Menzies-Gow, N. (2023). Short-term induced hyperinsulinaemia and dexamethasone challenge do not affect circulating total adiponectin concentrations in insulin-sensitive ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.14012

BackgroundHypoadiponectinaemia is a risk factor for endocrinopathic laminitis, but the directionality and nature of its association with insulin dysregulation is unclear.ObjectivesTo investigate the effects of short-term induced hyperinsulinaemia and... Read More about Short-term induced hyperinsulinaemia and dexamethasone challenge do not affect circulating total adiponectin concentrations in insulin-sensitive ponies.

Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies (2023)
Journal Article
Knowles, E., Harris, P., Elliott, J., Chang, Y., & Menzies-Gow, N. (2023). Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.13983

Background: Serum insulin concentration at 60 min (InsulinT60) during an oral sugar test (OST) indicates future laminitis risk and insulin dysregulation (ID). Associations between InsulinT60 and physical and owner-reported variables may help clinicia... Read More about Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies.

Therapeutics of managing reduced red cell mass associated with chronic kidney disease – is there a case for earlier intervention? (2023)
Journal Article
Elliott, J. (in press). Therapeutics of managing reduced red cell mass associated with chronic kidney disease – is there a case for earlier intervention?. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13127

Reduced red cell mass is a poor prognostic indicator in chronic kidney disease (CKD) patients. Whilst overt anaemia impacts on the quality of life of patients with CKD, lowered red cell mass may also compromise oxygen delivery to proximal tubular ce... Read More about Therapeutics of managing reduced red cell mass associated with chronic kidney disease – is there a case for earlier intervention?.

Short Communication: Identification of equine corticotropin-like intermediate lobe peptide (CLIP) binding to an adrenocortipcotrophic hormone (ACTH) assay capture antibody (2023)
Journal Article
Knowles, E., Hyde, C., Harris, P., Elliott, J., & Menzies-Gow, N. (2023). Short Communication: Identification of equine corticotropin-like intermediate lobe peptide (CLIP) binding to an adrenocortipcotrophic hormone (ACTH) assay capture antibody. Domestic Animal Endocrinology, https://doi.org/10.1016/j.domaniend.2023.106785

A chemiluminescent immunoassay is commonly employed to measure adrenocorticotrophic hormone (ACTH) concentrations to assist pituitary pars intermedia dysfunction diagnosis. In a previous study, seasonally dependent assay cross-reactivity to endogenou... Read More about Short Communication: Identification of equine corticotropin-like intermediate lobe peptide (CLIP) binding to an adrenocortipcotrophic hormone (ACTH) assay capture antibody.

Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom (2023)
Journal Article
Geddes, R. F., Davison, L. J., Elliott, J., Syme, H. M., & O'Neill, D. G. (2023). Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom. Journal of Veterinary Internal Medicine, 37(2), 567-577. https://doi.org/10.1111/jvim.16659

Background
Cats presenting with upper urinary tract uroliths (UUTUs) and ureteral obstruction (“obstructive UUTU”) are typically younger than cats with idiopathic CKD that often have incidental nephroliths.

Hypothesis
Cats with upper urinary tra... Read More about Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom.

A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis (2023)
Journal Article
Elliott, J. (2023). A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis. Equine Veterinary Journal, https://doi.org/10.1111/evj.13933

Equine laminitis has both fascinated and frustrated veterinary researchers and clinicians for many years. The recognition that many ponies suffering from pasture associated laminitis have an insulin dysregulated phenotype (endocrinopathic laminitis,... Read More about A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis.

A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis (2023)
Journal Article
Elliott, J., & Bailey, S. (in press). A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis. Equine Veterinary Journal, https://doi.org/10.1111/evj.13933

Equine laminitis has both fascinated and frustrated veterinary researchers and clinicians for many years. The recognition that many ponies suffering from pasture associated laminitis have an insulin dysregulated phenotype (endocrinopathic laminitis,... Read More about A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis.

Assessment of peritubular capillary rarefaction in kidneys of cats with chronic kidney disease (2023)
Journal Article
Paschall, R., Quimby, J., Cianciolo, R., McLeland, S., Lunn, K., & Elliott, J. (2023). Assessment of peritubular capillary rarefaction in kidneys of cats with chronic kidney disease. Journal of Veterinary Internal Medicine, 37(2), 556-566. https://doi.org/10.1111/jvim.16656

BackgroundHypoxia is a key driver of fibrosis and is associated with capillary rarefaction in humans. ObjectivesCharacterize capillary rarefaction in cats with chronic kidney disease (CKD). AnimalsArchival kidney tissue from 58 cats with CKD, 20 unaf... Read More about Assessment of peritubular capillary rarefaction in kidneys of cats with chronic kidney disease.

Relationships between total adiponectin concentrations and obesity in native-breed ponies in England (2023)
Journal Article
Barnabe, M., Elliott, J., Harris, P., & Menzies-Gow, N. (in press). Relationships between total adiponectin concentrations and obesity in native-breed ponies in England. Equine Veterinary Journal, https://doi.org/10.1111/evj.14013

Background: Equine metabolic syndrome is a collection of risk factors associated with an increased risk of endocrinopathic laminitis. All affected animals display insulin dysregulation and some may show adiponectin dysregulation and/or excessive adip... Read More about Relationships between total adiponectin concentrations and obesity in native-breed ponies in England.