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First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats (2022)
Journal Article
Jepson, R. E., Warren, H., Syme, H. M., Elliott, J., & Munroe, P. B. (2022). First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats. Scientific Reports, https://doi.org/10.1038/s41598-022-05494-3

Hypertension (HTN) and chronic kidney disease (CKD) are common in ageing cats. In humans, blood pressure (BP) and renal function are complex heritable traits. We performed the first feline Genome-Wide Association Study (GWAS) of quantitative traits s... Read More about First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats.

Risk factors and implications associated with renal mineralization in chronic kidney disease in cats (2022)
Journal Article
Tang, P., Jepson, R., Chang, Y., Geddes, R., Hopkinson, M., & Elliott, J. (2022). Risk factors and implications associated with renal mineralization in chronic kidney disease in cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16363

Background Nephrocalcinosis is a pathological feature of chronic kidney disease (CKD). Its pathophysiological implications for cats with CKD are unexplored. Objectives Identify nephrocalcinosis risk factors and evaluate its influence on CKD prog... Read More about Risk factors and implications associated with renal mineralization in chronic kidney disease in cats.

Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease (2021)
Journal Article
Wilshaw, J., Rosenthal, S., Wess, G., Dickson, D., Bevilacqua, L., Dutton, E., …Boswood, A. (2021). Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease. Journal of Veterinary Internal Medicine, 35(2), 755-770. https://doi.org/10.1111/jvim.16083

Background Treatment is indicated in dogs with preclinical degenerative mitral valve disease (DMVD) and cardiomegaly (stage B2). This is best diagnosed using echocardiography; however, relying upon this limits access to accurate diagnosis. Objectives... Read More about Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease.

The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia (2021)
Journal Article
Rebecca, F., van den Broek, D., Chang, Y., Biourge, V., Elliott, J., & Jepson, R. (2021). The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia. Journal of Veterinary Internal Medicine, 35(2), 997-1007. https://doi.org/10.1111/jvim.16050

Background Hypercalcemia is commonly observed in cats with azotemic chronic kidney disease (CKD). Dietary phosphate restriction is considered standard of care but may contribute to the development of hypercalcemia. The optimal dietary management stra... Read More about The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia.

The effect of myxomatous mitral valve disease severity on packed cell volume in dogs (2021)
Journal Article
Wilshaw, J., Stein, M., Lotter, N., Elliott, J., & Boswood, A. (2021). The effect of myxomatous mitral valve disease severity on packed cell volume in dogs. Journal of Small Animal Practice, 62(6), 428-436. https://doi.org/10.1111/jsap.13308

Objectives The aim of this study was to examine whether associations between disease severity and packed cell volume exist in dogs with myxomatous mitral valve disease. Materials and Methods Data were selected from 289 dogs that had been examined at... Read More about The effect of myxomatous mitral valve disease severity on packed cell volume in dogs.

Renal Senescence, Telomere Shortening and Nitrosative Stress in Feline Chronic Kidney Disease (2021)
Journal Article
Quimby, J., Erickson, A., Mcleland, S., Cianciolo, R., Maranon, D., Lunn, K., …Bailey, S. (2021). Renal Senescence, Telomere Shortening and Nitrosative Stress in Feline Chronic Kidney Disease. Veterinary Sciences, 8(12), https://doi.org/10.3390/vetsci8120314

Kidney tissues from cats with naturally occurring chronic kidney disease (CKD) and adult and senior cats without CKD were assessed to determine whether telomere shortening and nitrosative stress are associated with senescence in feline CKD. The histo... Read More about Renal Senescence, Telomere Shortening and Nitrosative Stress in Feline Chronic Kidney Disease.

Clinical progression of cats with early-stage chronic kidney disease fed diets with varying protein and phosphorus contents and calcium to phosphorus ratios (2021)
Journal Article
Schauf, S., Coltherd, J., Atwal, J., Gilham, M., Carvell-Miller, L., Renfrew, H., …Bakke, A. (2021). Clinical progression of cats with early-stage chronic kidney disease fed diets with varying protein and phosphorus contents and calcium to phosphorus ratios. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16263

Background Dietary protein and phosphorus (P) restriction is the mainstay for nutritional management of chronic kidney disease (CKD). However, adequate restriction levels for cats with early CKD remain unclear. Objectives To investigate responses in... Read More about Clinical progression of cats with early-stage chronic kidney disease fed diets with varying protein and phosphorus contents and calcium to phosphorus ratios.

Predictors of laminitis development in a cohort of non-laminitic ponies (2021)
Journal Article
Knowles, E., Elliott, J., Harris, P., Chang, R., & Menzies-Gow, N. (2021). Predictors of laminitis development in a cohort of non-laminitic ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.31_13492

Background: Quantifying the risk of laminitis development requires improvement. Objectives: To identify the most useful physical examination, metabolic and management factors to predict future laminitis development in client-owned, non-laminitic pon... Read More about Predictors of laminitis development in a cohort of non-laminitic ponies.

The use of ondansetron for the treatment of nausea in dogs with vestibular syndrome (2021)
Journal Article
Foth, S., Meller, S., Kenward, H., Elliott, J., Pelligand, L., & Volk, H. (2021). The use of ondansetron for the treatment of nausea in dogs with vestibular syndrome. BMC Veterinary Research, 17(1), https://doi.org/10.1186/s12917-021-02931-9

Background Vestibular syndrome is often accompanied by nausea. Drugs currently approved for its treatment have been developed to stop vomiting but not nausea. The efficacy of 5-HT3 receptor antagonists to reduce nausea has been described for chemothe... Read More about The use of ondansetron for the treatment of nausea in dogs with vestibular syndrome.

Changes in retinal vascular diameters in senior and geriatric cats in association with variation in systemic blood pressure (2021)
Journal Article
Enache, A., Dietrich, U., Drury, O., Trucco, E., MacGillivray, T., Syme, H., …Chang, Y. (2021). Changes in retinal vascular diameters in senior and geriatric cats in association with variation in systemic blood pressure. Journal of Feline Medicine and Surgery,

Objectives Early diagnosis of arterial hypertension is essential to prevent target organ damage. In humans, retinal arteriolar narrowing predicts hypertension. This blinded prospective observational study investigated the retinal vessel diameters amo... Read More about Changes in retinal vascular diameters in senior and geriatric cats in association with variation in systemic blood pressure.

Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate-restricted diet in cats with chronic kidney disease (2020)
Journal Article
Jepson, R., Elliott, J., Geddes, R., Chang, Y., & Tang, P. (2020). Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate-restricted diet in cats with chronic kidney disease. Journal of Veterinary Internal Medicine, 1-12. https://doi.org/10.1111/jvim.15996

Background Dietary phosphate restriction improves survival in cats with chronic kidney disease (CKD). However, feeding a phosphate‐restricted diet may disrupt calcium homeostasis leading to hypercalcemia in some cats. Objectives To identify... Read More about Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate-restricted diet in cats with chronic kidney disease.

Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease (2020)
Journal Article
Lawson, J., Syme, H., Wheeler-Jones, C., & Elliott, J. (2020). Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease. The Veterinary Journal, 267, 105582. https://doi.org/10.1016/j.tvjl.2020.105582

Chronic kidney disease (CKD) is common in geriatric cats, and is characterised in the majority of cases by tubulointerstitial inflammation and fibrosis. Hyperphosphataemia is a frequent complication of CKD and is independently associated with severit... Read More about Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease.

The new age of renal biomarkers: does SDMA solve all of our problems? (2020)
Journal Article
Sargent, H. J., Elliott, J., & Jepson, R. E. (2020). The new age of renal biomarkers: does SDMA solve all of our problems?. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13236

Within clinical small animal practice, diagnosis of both chronic kidney disease and acute kidney injury is common. To assess renal function, measurement of glomerular filtration rate is considered the gold standard. Currently, routine tests of kidney... Read More about The new age of renal biomarkers: does SDMA solve all of our problems?.

A review of phosphorus homeostasis and the impact of different types and amounts of dietary phosphate on metabolism and renal health in cats (2020)
Journal Article
Laflamme, D., Backus, R., Brown, S., Butterwick, R., Czarnecki‐Maulden, G., Elliott, J., …Polzin, D. (2020). A review of phosphorus homeostasis and the impact of different types and amounts of dietary phosphate on metabolism and renal health in cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15961

Elevated concentrations of serum phosphate are linked with progression and increased case fatality rate in animals and humans with chronic kidney disease. Elevated concentrations of serum phosphate can be a risk factor for development of renal and ca... Read More about A review of phosphorus homeostasis and the impact of different types and amounts of dietary phosphate on metabolism and renal health in cats.

An artificial neural network‐based model to predict chronic kidney disease in aged cats (2020)
Journal Article
Biourge, V., Delmotte, S., Feugier, A., Bradley, R., McAllister, M., & Elliott, J. (2020). An artificial neural network‐based model to predict chronic kidney disease in aged cats. Journal of Veterinary Internal Medicine, 34(5), 1920-1931

Background Chronic kidney disease (CKD) frequently causes death in older cats; its early detection is challenging. Objectives To build a sensitive and specific model for early prediction of CKD in cats using artificial neural network (ANN) t... Read More about An artificial neural network‐based model to predict chronic kidney disease in aged cats.

Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs (2020)
Journal Article
Pelligand, L., Guillot, E., Geneteau, A., Guyonnet, J., Magnier, R., Elliott, J., …Jacobs, M. (2020). Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs. Frontiers in Veterinary Science, 7, https://doi.org/10.3389/fvets.2020.00151

Torasemide is a loop diuretic licensed in dogs for cardiogenic pulmonary oedema. The aim of this pharmacokinetic-pharmacodynamic (PK/PD) study was to define an optimally effective dosage regimen based on preclinical data. In a first study, 5 dogs rec... Read More about Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs.

Aldosterone and the mineralocorticoid receptor in renal injury: A potential therapeutic target in feline chronic kidney disease (2020)
Journal Article
Spencer, S., Wheeler-Jones, C. P. D., & Elliott, J. (2020). Aldosterone and the mineralocorticoid receptor in renal injury: A potential therapeutic target in feline chronic kidney disease. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.12848

There is a growing body of experimental and clinical evidence supporting mineralocorticoid receptor (MR) activation as a powerful mediator of renal damage in laboratory animals and humans. Multiple pathophysiological mechanisms are proposed, with the... Read More about Aldosterone and the mineralocorticoid receptor in renal injury: A potential therapeutic target in feline chronic kidney disease.