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Dietary magnesium supplementation in cats with chronic kidney disease: A prospective double-blind randomized controlled trial (2024)
Journal Article
Tang, P., van den Broek, D., Jepson, R., Geddes, R., Chang, Y., Loetter, N., Moniot, D., Biourge, V., & Elliott, J. (2024). Dietary magnesium supplementation in cats with chronic kidney disease: A prospective double-blind randomized controlled trial. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17134

Background: Plasma total magnesium concentration (tMg) is a prognostic indicator in cats with chronic kidney disease (CKD), shorter survival time being associated with hypomagnesemia. Whether this risk factor is modifiable with dietary magnesium supp... Read More about Dietary magnesium supplementation in cats with chronic kidney disease: A prospective double-blind randomized controlled trial.

Risk factors and implications associated with ultrasound-diagnosed nephrocalcinosis in cats with chronic kidney disease (2024)
Journal Article
Tang, P.-K., Geddes, R. F., Chang, Y.-M., Jepson, R. E., Van Den Broek, D. H. N., Lötter, N., & Elliott, J. (in press). Risk factors and implications associated with ultrasound-diagnosed nephrocalcinosis in cats with chronic kidney disease. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17034

Background: Microscopic nephrocalcinosis is a common pathological feature of

Detection of nephrocalcinosis using ultrasonography, micro-computed tomography, and histopathology in cats (2024)
Journal Article
Tang, P., Geddes, R., Chang, Y., Jepson, R., van den Broek, D., Lötter, N., & Elliott, J. (2024). Detection of nephrocalcinosis using ultrasonography, micro-computed tomography, and histopathology in cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17011

BackgroundIdentification of nephrocalcinosis in cats with chronic kidney disease (CKD) is of clinical interest but the ability of ultrasonography to detect nephrocalcinosis is uncertain.ObjectivesTo compare ultrasonography, micro-computed tomography... Read More about Detection of nephrocalcinosis using ultrasonography, micro-computed tomography, and histopathology in cats.

Analysis of lower urinary tract signs and bacteriuria in cats with subcutaneous ureteral bypass systems (2023)
Journal Article
Djoneva, L., Lawson, J., Rutherford, L., & Geddes, R. (2023). Analysis of lower urinary tract signs and bacteriuria in cats with subcutaneous ureteral bypass systems. Vet Record Open, 10(2), https://doi.org/10.1002/vro2.69

ObjectivesDistinguishing bacterial cystitis from subclinical bacteriuria is necessary for feline treatment protocols and antimicrobial stewardship. This can be challenging in cats with subcutaneous ureteral bypass (SUB) systems because they may prese... Read More about Analysis of lower urinary tract signs and bacteriuria in cats with subcutaneous ureteral bypass systems.

Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom (2023)
Journal Article
Geddes, R. F., Davison, L. J., Elliott, J., Syme, H. M., & O'Neill, D. G. (2023). Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom. Journal of Veterinary Internal Medicine, 37(2), 567-577. https://doi.org/10.1111/jvim.16659

Background
Cats presenting with upper urinary tract uroliths (UUTUs) and ureteral obstruction (“obstructive UUTU”) are typically younger than cats with idiopathic CKD that often have incidental nephroliths.

Hypothesis
Cats with upper urinary tra... Read More about Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom.

Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019) (2023)
Journal Article
Broughton, S. E., O'Neill, D. G., Syme, H. M., & Geddes, R. F. (in press). Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019). Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16627

Background
Ionized calcium concentration ([iCa]) is more sensitive for detecting calcium disturbances than serum total calcium concentration but literature on ionized hypercalcemia in cats is limited. Urolithiasis is a possible adverse consequence o... Read More about Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019).

Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018) (2022)
Journal Article
van den Broek, D., Geddes, R., Lotter, N., Chang, Y., Elliott, J., & Jepson, R. (2022). Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018). Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16430

Background Hypercalcemia is associated with chronic kidney disease (CKD) in cats, but studies assessing the physiologically relevant ionized calcium fraction are lacking. Objectives To describe the prevalence and incidence rate of ionized hypercalcem... Read More about Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018).

Secondary Hypertension And Its Treatment In Cats (2022)
Journal Article
Geddes, R. (2022). Secondary Hypertension And Its Treatment In Cats. Companion Animal, https://doi.org/10.12968/coan.2021.0070

Secondary hypertension, due to an underlying disease, is common in older cats especially in cats with CKD and/or hyperthyroidism. Systolic blood pressure (SBP) should be measured whenever an associated disease is diagnosed and persistent SBP >160mmHg... Read More about Secondary Hypertension And Its Treatment In Cats.

New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat (2022)
Journal Article
Elliott, J., & Geddes, R. F. (2022). New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat. The Veterinary Journal, 283-284, Article 105842. https://doi.org/10.1016/j.tvjl.2022.105842

New discoveries relating to phosphorus homeostasis include the hormones fibroblast growth factor-23 and klotho produced by bone and kidney. These hormones, together with novel understanding of how calcium and phosphate ions are carried in colloidal f... Read More about New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat.

Feline Comorbidities: Balancing Hyperthyroidism and Concurrent Chronic Kidney Disease (2022)
Journal Article
Geddes, R., & Aguiar, J. (2022). Feline Comorbidities: Balancing Hyperthyroidism and Concurrent Chronic Kidney Disease. Journal of Feline Medicine and Surgery, https://doi.org/10.1177/1098612X221090390

Practical relevance - Both hyperthyroidism and chronic kidney disease are common long-lasting conditions in older cats, which might be diagnosed concurrently or develop at different times. Hyperthyroidism may mask the presence of chronic kidney disea... Read More about Feline Comorbidities: Balancing Hyperthyroidism and Concurrent Chronic Kidney Disease.

Risk factors and implications associated with renal mineralization in chronic kidney disease in cats (2022)
Journal Article
Tang, P., Jepson, R., Chang, Y., Geddes, R., Hopkinson, M., & Elliott, J. (2022). Risk factors and implications associated with renal mineralization in chronic kidney disease in cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16363

Background
Nephrocalcinosis is a pathological feature of chronic kidney disease (CKD). Its pathophysiological implications for cats with CKD are unexplored.

Objectives
Identify nephrocalcinosis risk factors and evaluate its influence on CKD prog... Read More about Risk factors and implications associated with renal mineralization in chronic kidney disease in cats.

The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia (2021)
Journal Article
Rebecca, F., van den Broek, D., Chang, Y., Biourge, V., Elliott, J., & Jepson, R. (2021). The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia. Journal of Veterinary Internal Medicine, 35(2), 997-1007. https://doi.org/10.1111/jvim.16050

Background Hypercalcemia is commonly observed in cats with azotemic chronic kidney disease (CKD). Dietary phosphate restriction is considered standard of care but may contribute to the development of hypercalcemia. The optimal dietary management stra... Read More about The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia.

Machine-learning based prediction of Cushing’s syndrome in dogs attending UK primary-care veterinary practice (2021)
Journal Article
Schofield, I., Brodbelt, D. C., Kennedy, N., Niessen, S. J. M., Church, D. B., Geddes, R. F., & O’Neill, D. G. (2021). Machine-learning based prediction of Cushing’s syndrome in dogs attending UK primary-care veterinary practice. Scientific Reports, 11(1), https://doi.org/10.1038/s41598-021-88440-z

Cushing’s syndrome is an endocrine disease in dogs that negatively impacts upon the quality-of-life of affected animals. Cushing’s syndrome can be a challenging diagnosis to confirm, therefore new methods to aid diagnosis are warranted. Four machine-... Read More about Machine-learning based prediction of Cushing’s syndrome in dogs attending UK primary-care veterinary practice.

Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate-restricted diet in cats with chronic kidney disease (2020)
Journal Article
Jepson, R., Elliott, J., Geddes, R., Chang, Y.-M., & Tang, P. (2020). Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate-restricted diet in cats with chronic kidney disease. Journal of Veterinary Internal Medicine, 1-12. https://doi.org/10.1111/jvim.15996

Background

Dietary phosphate restriction improves survival in cats with chronic kidney disease (CKD). However, feeding a phosphate‐restricted diet may disrupt calcium homeostasis leading to hypercalcemia in some cats.

Objectives

To identify... Read More about Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate-restricted diet in cats with chronic kidney disease.