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All Outputs (103)

Canine Respiratory Coronavirus: A Naturally Occurring Model of COVID-19? (2020)
Journal Article
Priestnall, S. L. (2020). Canine Respiratory Coronavirus: A Naturally Occurring Model of COVID-19?. Veterinary Pathology, https://doi.org/10.1177/0300985820926485

Discovered in 2003 at the Royal Veterinary College, London, canine respiratory coronavirus (CRCoV) is a betacoronavirus of dogs and major cause of canine infectious respiratory disease complex. Generally causing mild clinical signs of persistent coug... Read More about Canine Respiratory Coronavirus: A Naturally Occurring Model of COVID-19?.

Histiocytic sarcoma in miniature schnauzers: 30 cases (2020)
Journal Article
Purzycka, K., Peters, L. M., Elliott, J., Lamb, C. R., Priestnall, S. L., Hardas, A., Johnston, C. A., & Rodriguez‐Piza, I. (2020). Histiocytic sarcoma in miniature schnauzers: 30 cases. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13139

Objectives
To summarise the clinical presentation and outcomes in a series of miniature schnauzers diagnosed with histiocytic sarcoma.

Materials and Methods
Retrospective review of medical records of miniature schnauzers diagnosed with histiocyt... Read More about Histiocytic sarcoma in miniature schnauzers: 30 cases.

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis (2020)
Journal Article
Moreira-Teixeira, L., Tabone, O., Graham, C. M., Singhania, A., Stavropoulos, E., Redford, P. S., Chakravarty, P., Priestnall, S. L., Suarez-Bonnet, A., Herbert, E., Mayer-Barber, K. D., Sher, A., Fonseca, K. L., Sousa, J., Cá, B., Verma, R., Haldar, P., Saraiva, M., & O’Garra, A. (2020). Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis. Nature Immunology, 21(4), 464-476. https://doi.org/10.1038/s41590-020-0610-z

Although mouse infection models have been extensively used to study the host response to Mycobacterium tuberculosis, their validity in revealing determinants of human tuberculosis (TB) resistance and disease progression has been heavily debated. Here... Read More about Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis.

Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation (2020)
Journal Article
Wu, Y., Chang, Y. M., Polton, G., Stell, A. J., Szladovits, B., Macfarlane, M., Peters, L. M., Priestnall, S. L., Bacon, N. J., Kow, K., Stewart, S., Sharma, E., Goulart, M. R., Gribben, J., Xia, D., & Garden, O. A. (2020). Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation. Frontiers in Oncology, 10, https://doi.org/10.3389/fonc.2020.00307

Gene expression profiling has revealed molecular heterogeneity of diffuse large B cell lymphoma (DLBCL) in both humans and dogs. Two DLBCL subtypes based on cell of origin are generally recognized, germinal center B (GCB)-like and activated B cell (A... Read More about Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation.

Avian Papilloma and Squamous Cell Carcinoma: a Histopathological, Immunohistochemical and Virological study (2020)
Journal Article
Jones, A. L., Suárez-Bonnet, A., Mitchell, J. A., Ramirez, G. A., Stidworthy, M. F., & Priestnall, S. L. (2020). Avian Papilloma and Squamous Cell Carcinoma: a Histopathological, Immunohistochemical and Virological study. Journal of Comparative Pathology, 175, 13-23. https://doi.org/10.1016/j.jcpa.2019.11.007

In this retrospective study, we describe the histopathological findings in seven papillomas and 45 squamous cell carcinomas (SCCs) from psittacine birds, raptors and domestic fowl. The age of affected birds ranged from 3 to 40 years, with median age... Read More about Avian Papilloma and Squamous Cell Carcinoma: a Histopathological, Immunohistochemical and Virological study.

Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice (2019)
Journal Article
Ying Wu, Chang, Y. M., Stell, A. J., Priestnall, S. L., Sharma, E., Goulart, M. R., Gribben, J., Xia, D., & Garden, O. A. (2019). Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice. https://doi.org/10.1038/s41598-019-50065-8

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been i... Read More about Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.

Canine Ependymoma: Diagnostic Criteria and Common Pitfalls (2019)
Journal Article
Miller, A. D., Koehler, J. W., Donovan, T. A., Stewart, J. E., Porter, B. F., Rissi, D. R., Priestnall, S. L., & Schulman, F. Y. (2019). Canine Ependymoma: Diagnostic Criteria and Common Pitfalls. Veterinary Pathology, 56(6), 860-867. https://doi.org/10.1177/0300985819859872

Reports of canine ependymoma are generally restricted to single case reports with tumor incidence estimated at 2% to 3% of primary central nervous system (CNS) tumors. While most commonly reported in the lateral ventricle, tumors can occur anywhere i... Read More about Canine Ependymoma: Diagnostic Criteria and Common Pitfalls.

Bilateral capital physeal dysplasia in a ferret (Mustela putorius furo) treated with femoral head ostectomy (2019)
Journal Article
Swaffield, M., Hedley, J., Stapleton, N., Priestnall, S. L., Suárez-Bonnet, A., & Baldrey, V. (2019). Bilateral capital physeal dysplasia in a ferret (Mustela putorius furo) treated with femoral head ostectomy. Journal of Exotic Pet Medicine, https://doi.org/10.1053/j.jepm.2019.05.003

A six-month-old male entire ferret presented for investigation of atraumatic bilateral pelvic limb lameness. Radiographic and subsequent histopathological assessment of the femoral heads following bilateral femoral head ostectomy was consistent with... Read More about Bilateral capital physeal dysplasia in a ferret (Mustela putorius furo) treated with femoral head ostectomy.

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases (2019)
Journal Article
Singhania, A., Graham, C. M., Gabryšová, L., Moreira-Teixeira, L., Stavropoulos, E., Pitt, J. M., Chakravarty, P., Warnatsch, A., Branchett, W. J., Conejero, L., Lin, J.-W., Davidson, S., Wilson, M. S., Bancroft, G., Langhorne, J., Frickel, E., Sesay, A. K., Priestnall, S. L., Herbert, E., Ioannou, M., …O’Garra, A. (2019). Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases. Nature Communications, 10, https://doi.org/10.1038/s41467-019-10601-6

Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation... Read More about Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.

Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome (2019)
Journal Article
Pittaway, R., Dobromylskyj, M. J., Erles, K., Pittaway, C. E., Suárez-Bonnet, A., Chang, Y. M., & Priestnall, S. L. (2019). Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome. Veterinary Pathology, 56(6), 868-877. https://doi.org/10.1177/0300985819854435

Nonocular melanocytic neoplasia is considered uncommon in cats yet is routinely encountered in diagnostic pathology and recognized to exhibit a wide variation in biological behavior. Accurate prediction of clinical outcomes is challenging with no wid... Read More about Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome.

Lymphatic endothelial cell immunohistochemical markers for evaluation of the intestinal lymphatic vasculature in dogs with chronic inflammatory enteropathy (2019)
Journal Article
Wennogle, S. A., Priestnall, S. L., Suárez-Bonnet, A., Soontararak, S., & Webb, C. B. (2019). Lymphatic endothelial cell immunohistochemical markers for evaluation of the intestinal lymphatic vasculature in dogs with chronic inflammatory enteropathy. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15545

Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease (2019)
Journal Article
Allenspach, K., Mochel, J. P., Du, Y., Priestnall, S. L., Moore, F., Slayter, M., Rodrigues, A., Ackermann, M., Krockenberger, M., Mansell, J., Luckschander, N., Wang, C., Suchodolski, J., Berghoff, N., & Jergens, A. E. (2019). Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease. Veterinary Pathology, 56(3), 435-443. https://doi.org/10.1177/0300985818813090

Prior studies have failed to detect a convincing association between histologic lesions of inflammation and clinical activity in dogs with inflammatory bowel disease (IBD). We hypothesized that use of a simplified histopathologic scoring system would... Read More about Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease.

Malignant Cutaneous Peripheral Nerve Sheath Tumour with Rhabdomyosarcomatous Differentiation (Triton Tumour) in a Domestic Cat (2018)
Journal Article
Stoll, A. L., Suárez-Bonnet, A., Summers, B. A., & Priestnall, S. L. (2018). Malignant Cutaneous Peripheral Nerve Sheath Tumour with Rhabdomyosarcomatous Differentiation (Triton Tumour) in a Domestic Cat. Journal of Comparative Pathology, 165, 1-5. https://doi.org/10.1016/j.jcpa.2018.09.003

Divergent differentiation is encountered frequently within human malignant peripheral nerve sheath tumours (MPNSTs). The new component is often a rhabdomyosarcoma, but in animals this specific form of divergent differentiation within MPNSTs has only... Read More about Malignant Cutaneous Peripheral Nerve Sheath Tumour with Rhabdomyosarcomatous Differentiation (Triton Tumour) in a Domestic Cat.

Observational Study Design in Veterinary Pathology, Part 2: Methodology (2018)
Journal Article
Caswell, J. L., Bassel, L. L., Rothenburger, J. L., Gröne, A., Sargeant, J. M., Beck, A. P., Ekman, S., Gibson-Corley, K. N., Kuiken, T., LaDouceur, E. E. B., Meyerholz, D. K., Origgi, F. C., Posthaus, H., Priestnall, S. L., Ressel, L., Sharkey, L., Teixeira, L. B. C., Uchida, K., Ward, J. M., Webster, J. D., & Yamate, J. (2018). Observational Study Design in Veterinary Pathology, Part 2: Methodology. Veterinary Pathology, 55(6), 774-785. https://doi.org/10.1177/0300985818798121

Observational studies are a basis for much of our knowledge of veterinary pathology, yet considerations for conducting pathology-based observational studies are not readily available. In part 1 of this series, we offered advice on planning and carryi... Read More about Observational Study Design in Veterinary Pathology, Part 2: Methodology.

Cutaneous Botryomycosis in Two Pet Rabbits (2018)
Journal Article
Hedley, J., Stapleton, N., Muir, C., Priestnall, S. L., & Smith, K. (2018). Cutaneous Botryomycosis in Two Pet Rabbits. Journal of Exotic Pet Medicine, 28, 143-147. https://doi.org/10.1053/j.jepm.2018.01.005

A 5-year-old male neutered rabbit was presented for assessment of multiple abscesses, which had appeared suddenly over the ventrum, perineum and hindlimbs over the previous few days. Thirteen abscesses were surgically excised. Culture revealed Pseudo... Read More about Cutaneous Botryomycosis in Two Pet Rabbits.

Odontoameloblastoma with extensive chondroid matrix deposition in a guinea pig (2018)
Journal Article
Wong, H. E., Hedley, J., Stapleton, N., Murphy, B., & Priestnall, S. L. (2018). Odontoameloblastoma with extensive chondroid matrix deposition in a guinea pig. Journal of Veterinary Diagnostic Investigation, https://doi.org/10.1177/1040638718794784

Odontoameloblastomas (previously incorporated within ameloblastic odontomas) are matrix-producing odontogenic mixed tumors and are closely related in histologic appearance to the 2 other types of matrix-producing odontogenic mixed tumors: odontomas a... Read More about Odontoameloblastoma with extensive chondroid matrix deposition in a guinea pig.

Observational Study Design in Veterinary Pathology, Part 1: Study Design (2018)
Journal Article
Caswell, J. L., Bassel, L. L., Rothenburger, J. L., Gröne, A., Sargeant, J. M., Beck, A. P., Ekman, S., Gibson-Corley, K. N., Kuiken, T., LaDouceur, E. E. B., Meyerholz, D. K., Origgi, F. C., Posthaus, H., Priestnall, S. L., Ressel, L., Sharkey, L., Teixeira, L. B. C., Uchida, K., Ward, J. M., Webster, J. D., & Yamate, J. (2018). Observational Study Design in Veterinary Pathology, Part 1: Study Design. Veterinary Pathology, 55(6), https://doi.org/10.1177/0300985818785705

Observational studies are the basis for much of our knowledge of veterinary pathology and are highly relevant to the daily practice of pathology. However, recommendations for conducting pathology-based observational studies are not readily available.... Read More about Observational Study Design in Veterinary Pathology, Part 1: Study Design.