R Pittaway
Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry
Pittaway, R; Wu, Y; Suárez-Bonnet, A; Szladovits, B; Scurrell, E J; Garden, O A; Polton, G; Priestnall, S L
Authors
Y Wu
A Suárez-Bonnet
B Szladovits
E J Scurrell
O A Garden
G Polton
S L Priestnall
Abstract
Anaplastic large-cell lymphoma or null-cell lymphoma is a clinical entity reported in people, classified according to the unique appearance of large pleomorphic cells that express CD30. Null-cell lymphoma has also been described in dogs when neither CD3 nor CD79? is expressed by the tumor. We describe a case of lymphoma in the dog in which neoplastic cells did not express routine B- or T-lymphocyte markers on flow cytometry or immunohistochemistry; however, cells immunohistochemically labeled for CD30. The dog in our case died 5 mo after initial presentation, confirming a poor prognosis. Identification of further similar cases in dogs would provide additional prognostic information for this subset of lymphomas. CD30 may also serve as a potential therapeutic target in anaplastic large-cell lymphomas.
Citation
Pittaway, R., Wu, Y., Suárez-Bonnet, A., Szladovits, B., Scurrell, E. J., Garden, O. A., …Priestnall, S. L. (2018). Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry. Journal of Veterinary Diagnostic Investigation, https://doi.org/10.1177/1040638718760965
Journal Article Type | Other |
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Acceptance Date | Feb 1, 2018 |
Publication Date | Feb 19, 2018 |
Deposit Date | Mar 10, 2018 |
Publicly Available Date | Nov 21, 2020 |
Journal | JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION |
Print ISSN | 1040-6387 |
Publisher | SAGE Publications |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1177/1040638718760965 |
Keywords | CD30, dogs, immunohistochemistry, lymphoma, null-cell lymphoma |
Public URL | https://rvc-repository.worktribe.com/output/1388532 |
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