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Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry

Pittaway, R; Wu, Y; Suárez-Bonnet, A; Szladovits, B; Scurrell, E J; Garden, O A; Polton, G; Priestnall, S L


R Pittaway

Y Wu

A Suárez-Bonnet

B Szladovits

E J Scurrell

O A Garden

G Polton

S L Priestnall


Anaplastic large-cell lymphoma or null-cell lymphoma is a clinical entity reported in people, classified according to the unique appearance of large pleomorphic cells that express CD30. Null-cell lymphoma has also been described in dogs when neither CD3 nor CD79α is expressed by the tumor. We describe a case of lymphoma in the dog in which neoplastic cells did not express routine B- or T-lymphocyte markers on flow cytometry or immunohistochemistry; however, cells immunohistochemically labeled for CD30. The dog in our case died 5 mo after initial presentation, confirming a poor prognosis. Identification of further similar cases in dogs would provide additional prognostic information for this subset of lymphomas. CD30 may also serve as a potential therapeutic target in anaplastic large-cell lymphomas.


Pittaway, R., Wu, Y., Suárez-Bonnet, A., Szladovits, B., Scurrell, E. J., Garden, O. A., …Priestnall, S. L. (2018). Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry. Journal of Veterinary Diagnostic Investigation,

Journal Article Type Other
Acceptance Date Feb 1, 2018
Publication Date Feb 19, 2018
Deposit Date Mar 10, 2018
Publicly Available Date Mar 10, 2018
Print ISSN 1040-6387
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Keywords CD30, dogs, immunohistochemistry, lymphoma, null-cell lymphoma
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