Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry

Pittaway, R; Wu, Y; Suárez-Bonnet, A; Szladovits, B; Scurrell, E J; Garden, O A; Polton, G; Priestnall, S L

Abstract

Anaplastic large-cell lymphoma or null-cell lymphoma is a clinical entity reported in people, classified according to the unique appearance of large pleomorphic cells that express CD30. Null-cell lymphoma has also been described in dogs when neither CD3 nor CD79α is expressed by the tumor. We describe a case of lymphoma in the dog in which neoplastic cells did not express routine B- or T-lymphocyte markers on flow cytometry or immunohistochemistry; however, cells immunohistochemically labeled for CD30. The dog in our case died 5 mo after initial presentation, confirming a poor prognosis. Identification of further similar cases in dogs would provide additional prognostic information for this subset of lymphomas. CD30 may also serve as a potential therapeutic target in anaplastic large-cell lymphomas.

Citation

Pittaway, R., Wu, Y., Suárez-Bonnet, A., Szladovits, B., Scurrell, E. J., Garden, O. A., …Priestnall, S. L. (2018). Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry. Journal of Veterinary Diagnostic Investigation, https://doi.org/10.1177/1040638718760965

• Journal Article Type: Other
• Acceptance Date: Feb 1, 2018
• Publication Date: Feb 19, 2018
• Deposit Date: Mar 10, 2018
• Publicly Available Date: Mar 10, 2018
• Journal: JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
• Print ISSN: 1040-6387
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1177/1040638718760965
• Keywords: CD30, dogs, immunohistochemistry, lymphoma, null-cell lymphoma
• Public URL: https://rvc-repository.worktribe.com/output/1388532