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Portovenography Findings Following Partial Polypropylene Versus Thin Film Band Attenuation of a Single Congenital Extrahepatic Portosystemic Shunt: A Prospective Randomized Study in Dogs (2023)
Journal Article
Lipscomb, V., Tivers, M., Kummeling, A., & van Sluijs, F. (2023). Portovenography Findings Following Partial Polypropylene Versus Thin Film Band Attenuation of a Single Congenital Extrahepatic Portosystemic Shunt: A Prospective Randomized Study in Dogs. Veterinary Sciences, 10(5), https://doi.org/10.3390/vetsci10050353

Simple SummaryDogs may be born with an abnormal vessel that bypasses their liver (congenital portosystemic shunt), causing a variety of clinical signs due to toxins building up in the bloodstream. Closing the abnormal vessel completely in a one-stage... Read More about Portovenography Findings Following Partial Polypropylene Versus Thin Film Band Attenuation of a Single Congenital Extrahepatic Portosystemic Shunt: A Prospective Randomized Study in Dogs.

Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells (2021)
Journal Article
Regan, J., Mirczuk, S., Scudder, C., Stacey, E., Khan, S., Powles, T., …Fowkes, R. (2021). Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells. Cells, https://doi.org/10.3390/cells10020398

C-type natriuretic peptide (CNP) is the major natriuretic peptide of the central nervous system and acts via its selective guanylyl cyclase-B (GC-B) receptor to regulate cGMP production in neurons, astrocytes and endothelial cells. CNP is implicated... Read More about Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells.

Treatment and outcomes of ureter injuries due to ovariohysterectomy complications in cats and dogs (2020)
Journal Article
Plater, B. L., & Lipscomb, V. J. (2020). Treatment and outcomes of ureter injuries due to ovariohysterectomy complications in cats and dogs. Journal of Small Animal Practice, 61(3), 170-176

Objectives To describe the presentation, treatment and outcome of unilateral and bilateral ureter injuries resulting from ovariohysterectomy complications in cats and dogs. Materials and Methods Retrospective case series of cats and dogs wit... Read More about Treatment and outcomes of ureter injuries due to ovariohysterectomy complications in cats and dogs.

Use of subcutaneous ureteral bypass systems as a bridge to definitive ureteral repair in a cat with bilateral ureteral ligation secondary to complicated ovariohysterectomy (2019)
Journal Article
Beer, A., Lipscomb, V. J., Rutherford, L., & Lee, K. C. L. (2019). Use of subcutaneous ureteral bypass systems as a bridge to definitive ureteral repair in a cat with bilateral ureteral ligation secondary to complicated ovariohysterectomy. https://doi.org/10.1136/vetreccr-2018-000758

A kitten presented with acute kidney injury, bilateral hydronephrosis and proximal hydroureter, three days following bilateral ureteral ligation, during a complicated ovariohysterectomy procedure. Clinical signs were anorexia, lethargy, weakness, hyp... Read More about Use of subcutaneous ureteral bypass systems as a bridge to definitive ureteral repair in a cat with bilateral ureteral ligation secondary to complicated ovariohysterectomy.

Intraoperative and major postoperative complications and survival of dogs undergoing surgical management of epiglottic retroversion: 50 dogs (2003-2017) (2019)
Journal Article
Mullins, R. A., Stanley, B. J., Flanders, J. A., López, P. P., Collivignarelli, F., Doyle, R. S., …McAlinden, A. B. (2019). Intraoperative and major postoperative complications and survival of dogs undergoing surgical management of epiglottic retroversion: 50 dogs (2003-2017). Veterinary Surgery, https://doi.org/10.1111/vsu.13226

Health-related quality of life following surgical attenuation of congenital portosystemic shunts versus a healthy control population of dogs (2019)
Journal Article
Bristow, P. C., Lipscomb, V. J., Kummeling, A., Packer, R. M. A., Gerrits, H., Homan, K., …Tivers, M. S. (2019). Health-related quality of life following surgical attenuation of congenital portosystemic shunts versus a healthy control population of dogs. Journal of Small Animal Practice, 60(1), 21-26. https://doi.org/10.1111/jsap.12927

Intrahepatic congenital portosystemic shunts in dogs: short- and long-term outcome of suture attenuation (2018)
Journal Article
Tivers, M. S., Lipscomb, V. J., Bristow, P. C., & Brockman, D. J. (2018). Intrahepatic congenital portosystemic shunts in dogs: short- and long-term outcome of suture attenuation. Journal of Small Animal Practice, 59(4), 201-210. https://doi.org/10.1111/jsap.12788

Retrospective cohort study of dogs surgically treated for intrahepatic congenital portosystemic shunts between February 2000 and March 2015. Long-term follow-up was conducted by telephone conversations with the referring veterinary surgeon, owner, or... Read More about Intrahepatic congenital portosystemic shunts in dogs: short- and long-term outcome of suture attenuation.

Aldosterone-producing adrenocortical carcinoma with myxoid differentiation in a cat (2018)
Journal Article
Attipa, C., Beck, S., Lipscomb, V. J., English, K., Carvalho, S., Kiupel, M., …Peters, L. M. (2018). Aldosterone-producing adrenocortical carcinoma with myxoid differentiation in a cat. Veterinary Clinical Pathology, 47(4), 660-664. https://doi.org/10.1111/vcp.12658

A 10‐year‐old male neutered Persian cat was presented with an abdominal mass and history of weakness. Blood smear examination found marked elliptocytosis, and serum biochemical analysis revealed hypokalemia, hypochloremia, increased creatine kinase a... Read More about Aldosterone-producing adrenocortical carcinoma with myxoid differentiation in a cat.

Treatment of intrahepatic congenital portosystemic shunts in dogs: a systematic review (2017)
Journal Article
Tivers, M. S., Lipscomb, V. J., & Brockman, D. J. (2017). Treatment of intrahepatic congenital portosystemic shunts in dogs: a systematic review. Journal of Small Animal Practice, 58(9), 485-494. https://doi.org/10.1111/jsap.12712

The aim of this study was to establish the evidence base for the treatment of intrahepatic congenital portosystemic shunts in dogs through a systematic review of the pertinent literature. Studies were filtered for evidence to answer the question “Whi... Read More about Treatment of intrahepatic congenital portosystemic shunts in dogs: a systematic review.

Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes (2017)
Journal Article
Jonas, K. C., Melrose, T., Thompson, I. R., Baxter, G. F., Lipscomb, V. J., Niessen, S. J. M., …Fowkes, R. C. (2017). Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes. Cell and Tissue Research, 369(3), 567-578. https://doi.org/10.1007/s00441-017-2624-x

The natriuretic peptides, Atrial-, B-type and C-type natriuretric peptides (ANP, BNP, CNP), are regulators of many endocrine tissues and exert their effects predominantly through the activation of their specific guanylyl cyclase receptors (GC-A and G... Read More about Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes.

Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts (2015)
Journal Article
Tivers, M. S., Lipscomb, V. J., Smith, K. C., Wheeler-Jones, C. P. D., & House, A. K. (2015). Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts. https://doi.org/10.1016/j.tvjl.2015.07.006

Surgical attenuation of a congenital portosystemic shunt (CPSS) results in increased portal vein perfusion, liver growth and clinical improvement. Portal lipopolysaccharide (LPS) is implicated in liver regeneration via toll-like receptor (TLR) 4 medi... Read More about Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts.

Multiple acquired portosystemic shunts in a cat secondary to chronic diaphragmatic rupture (2015)
Journal Article
Barfield, D. M., Gibson, A. D., & Lipscomb, V. J. (2015). Multiple acquired portosystemic shunts in a cat secondary to chronic diaphragmatic rupture. Journal of Feline Medicine and Surgery Open Reports, 1(2), 1. https://doi.org/10.1177/2055116915585020

A cat with a chronic diaphragmatic rupture presented with neurological signs, including twitching and focal seizures. Blood ammonia level was markedly elevated and therefore neurological signs were thought to be related to hepatic encephalopathy. Exp... Read More about Multiple acquired portosystemic shunts in a cat secondary to chronic diaphragmatic rupture.

Attenuation of Congenital Portosystemic Shunt Reduces Inflammation in Dogs (2015)
Journal Article
Tivers, M. S., Handel, I., Gow, A. G., Lipscomb, V. J., Jalan, R., & Mellanby, R. J. (2015). Attenuation of Congenital Portosystemic Shunt Reduces Inflammation in Dogs. PLoS ONE, 10(2), https://doi.org/10.1371/journal.pone.0117557

Liver disease is a major cause of morbidity and mortality. One of the most significant complications in patients with liver disease is the development of neurological disturbances, termed hepatic encephalopathy. The pathogenesis of hepatic encephalop... Read More about Attenuation of Congenital Portosystemic Shunt Reduces Inflammation in Dogs.