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All Outputs (154)

Serum Biochemical Phenotypes in the Domestic Dog (2016)
Journal Article
Chang, Y. M., Hadox, E., Szladovits, B., & Garden, O. A. (2016). Serum Biochemical Phenotypes in the Domestic Dog. PLoS ONE, 11(2), e0149650. https://doi.org/10.1371/journal.pone.0149650

The serum or plasma biochemical profile is essential in the diagnosis and monitoring of systemic disease in veterinary medicine, but current reference intervals typically take no account of breed-specific differences. Breed-specific hematological phe... Read More about Serum Biochemical Phenotypes in the Domestic Dog.

Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing (2015)
Journal Article
Javaheri, B., Carriero, A., Staines, K. A., Chang, Y. M., Houston, D. A., Oldknow, K. J., …Pitsillides, A. A. (2015). Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing. BONE, 81, 277-291. https://doi.org/10.1016/j.bone.2015.07.035

PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalaci... Read More about Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing.

Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure (2015)
Journal Article
Baker, L. A., Lee, K. C. L., Jimenez, C. P., Alibhai, H. I. K., Chang, Y. M., Leckie, P. J., …Jalan, R. (2015). Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure. PLoS ONE, 10(5), https://doi.org/10.1371/journal.pone.0128076

Acute liver failure is a rare but catastrophic condition which can progress rapidly to multi-organ failure. Studies investigating the onset of individual organ injury such as the liver, kidneys and brain during the evolution of acute liver failure, a... Read More about Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure.

Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study (2015)
Journal Article
Lee, K. C. L., Baker, L. A., Stanzani, G., Alibhai, H. I. K., Chang, Y. M., Palacios, C. J., …Jalan, R. (2015). Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study. Journal of Hepatology, 63(3), 634-642. https://doi.org/10.1016/j.jhep.2015.04.020

A Prospective, Randomized, Blinded, Placebo-Controlled Pilot Study on the Effect of Enterococcus faecium on Clinical Activity and Intestinal Gene Expression in Canine Food-Responsive Chronic Enteropathy (2015)
Journal Article
Schmitz, S., Glanemann, B., Garden, O. A., Brooks, H. W., Chang, Y. M., Werling, D., & Allenspach, K. (2015). A Prospective, Randomized, Blinded, Placebo-Controlled Pilot Study on the Effect of Enterococcus faecium on Clinical Activity and Intestinal Gene Expression in Canine Food-Responsive Chronic Enteropathy. Journal of Veterinary Internal Medicine, 29(2), 533-43. https://doi.org/10.1111/jvim.12563

Dissecting the Regulatory Microenvironment of a Large Animal Model of Non-Hodgkin Lymphoma: Evidence of a Negative Prognostic Impact of FOXP3+ T Cells in Canine B Cell Lymphoma (2014)
Journal Article
Pinheiro, D. Y., Chang, Y. M., Bryant, H., Szladovits, B., Dalessandri, T., Davison, L. J., …Garden, O. A. (2014). Dissecting the Regulatory Microenvironment of a Large Animal Model of Non-Hodgkin Lymphoma: Evidence of a Negative Prognostic Impact of FOXP3+ T Cells in Canine B Cell Lymphoma. PLoS ONE, 9(8), e105027. https://doi.org/10.1371/journal.pone.0105027

The cancer microenvironment plays a pivotal role in oncogenesis, containing a number of regulatory cells that attenuate the anti-neoplastic immune response. While the negative prognostic impact of regulatory T cells (Tregs) in the context of most sol... Read More about Dissecting the Regulatory Microenvironment of a Large Animal Model of Non-Hodgkin Lymphoma: Evidence of a Negative Prognostic Impact of FOXP3+ T Cells in Canine B Cell Lymphoma.

Herd-Level Risk Factors for the Seropositivity to Mycoplasma hyopneumoniae and the Occurrence of Enzootic Pneumonia Among Fattening Pigs in Areas of Endemic Infection and High Pig Density (2014)
Journal Article
Nathues, H., Chang, Y. M., Wieland, B., Rechter, G., Spergser, J., Rosengarten, R., …Beilage, E. G. (2014). Herd-Level Risk Factors for the Seropositivity to Mycoplasma hyopneumoniae and the Occurrence of Enzootic Pneumonia Among Fattening Pigs in Areas of Endemic Infection and High Pig Density. Transboundary and Emerging Diseases, 61(4), 316-328. https://doi.org/10.1111/tbed.12033

The aim of the present study was to identify potential risk factors for the occurrence of enzootic pneumonia (EP) in herds situated in a region of high pig density, where a majority of herds is endemically infected with Mycoplasma hyopneumoniae. Betw... Read More about Herd-Level Risk Factors for the Seropositivity to Mycoplasma hyopneumoniae and the Occurrence of Enzootic Pneumonia Among Fattening Pigs in Areas of Endemic Infection and High Pig Density.

Nevus density and melanoma risk in women: a pooled analysis to test the divergent pathway hypothesis (2009)
Journal Article
Olsen, C. M., Zens, M. S., Stukel, T. A., Sacerdote, C., Chang, Y. M., Armstrong, B. K., …Whiteman, D. C. (2009). Nevus density and melanoma risk in women: a pooled analysis to test the divergent pathway hypothesis. International Journal of Cancer, 124(4), 937-944. https://doi.org/10.1002/ijc.24011

A “divergent pathway” model for the development of cutaneous melanoma has been proposed. The model hypothesizes that melanomas occurring in people with a low tendency to develop nevi will, on average, arise more commonly on habitually sun‐exposed bod... Read More about Nevus density and melanoma risk in women: a pooled analysis to test the divergent pathway hypothesis.