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Efficacy and safety of once daily oral administration of sodium-glucose cotransporter-2 inhibitor velagliflozin compared with twice daily insulin injection in diabetic cats (2024)
Journal Article
Niessen, S., Kooistra, H., Forcada, Y., Bjornvad, C., Albrecht, B., Roessner, F., Herberich, E., & Kroh, C. (2024). Efficacy and safety of once daily oral administration of sodium-glucose cotransporter-2 inhibitor velagliflozin compared with twice daily insulin injection in diabetic cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17124

Background: Options for treatment of diabetes mellitus in cats are limited to insulin injections and monitoring for hypoglycemia. Hypothesis: Once daily sodium-glucose cotransporter-2 inhibitor velagliflozin PO is noninferior to insulin injections. A... Read More about Efficacy and safety of once daily oral administration of sodium-glucose cotransporter-2 inhibitor velagliflozin compared with twice daily insulin injection in diabetic cats.

Epidemiological investigation of foot-and-mouth disease outbreaks in a Vietnamese bear rescue centre (2024)
Journal Article
Ludi, A., Baker, H., Sanki, R., De Jong, R., Maryan, J., Walker, M., King, D., Gubbins, S., Limon, G., & Officer, K. (2024). Epidemiological investigation of foot-and-mouth disease outbreaks in a Vietnamese bear rescue centre. Frontiers in Veterinary Science, 11, https://doi.org/10.3389/fvets.2024.1389029

Foot-and-mouth disease (FMD) outbreaks affecting Asiatic black bears (Ursus thibetanus) and a Malayan sun bear (Helarctos malayanus) were previously reported in 2011 in two housing facilities at a Vietnamese bear rescue centre. In this study, demogra... Read More about Epidemiological investigation of foot-and-mouth disease outbreaks in a Vietnamese bear rescue centre.

Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response (2024)
Journal Article
Corsiero, E., Caliste, M., Jagemann, L., Fossati-Jimack, L., Goldmann, K., Cubuk, C., Ghirardi, G., Prediletto, E., Rivellese, F., Alessandri, C., Hopkinson, M., Javaheri, B., Pitsillides, A., Lewis, M., Pitzalis, C., & Bombardieri, M. (2024). Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response. Journal of Clinical Investigation, 134(12), https://doi.org/10.1172/JCI169754

Ectopic lymphoid structures (ELSs) in the rheumatoid synovial joints sustain autoreactivity against locally expressed autoantigens. We recently identified recombinant monoclonal antibodies (RA-rmAbs) derived from single, locally differentiated rheuma... Read More about Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response.

CD117 expression in canine ovarian tumours (2024)
Journal Article
Mallon, H., Ramírez, G., Dolensek, T., Erles, K., Martí-Garcia, B., Priestnall, S., & Suárez-Bonnet, A. (2024). CD117 expression in canine ovarian tumours. Journal of Comparative Pathology, 212, 1-5. https://doi.org/10.1016/j.jcpa.2024.05.001

Canine ovarian cancer poses a significant diagnostic and therapeutic challenge. The heterogeneous nature of ovarian tumours makes accurate histological identification difficult, whilst treatment is limited to surgical excision. The tyrosine kinase re... Read More about CD117 expression in canine ovarian tumours.

<i>Plasmodium</i> LCCL domain-containing modular proteins have their origins in the ancestral alveolate (2024)
Journal Article
De Hoest-Thompson, C., Marugan-Hernandez, V., & Dessens, J. (2024). Plasmodium LCCL domain-containing modular proteins have their origins in the ancestral alveolate. Open Biology, 14(6), https://doi.org/10.1098/rsob.230451

Plasmodium species encode a unique set of six modular proteins named LCCL lectin domain adhesive-like proteins (LAPs) that operate as a complex and that are essential for malaria parasite transmission from mosquito to vertebrate. LAPs possess complex... Read More about <i>Plasmodium</i> LCCL domain-containing modular proteins have their origins in the ancestral alveolate.

Determinants of Thoroughbred yearling sales price in the UK (2024)
Journal Article
Mouncey, R. R., Alarcon, P., & Verheyen, K. L. (2024). Determinants of Thoroughbred yearling sales price in the UK. Veterinary Record Open, 11(1), https://doi.org/10.1002/vro2.81

Background
Industry-level figures suggest that up to two-thirds of Thoroughbred breeding operations in the UK are unprofitable and that around half of sales transactions of Thoroughbred yearlings, commercial breeders’ predominant income source, retu... Read More about Determinants of Thoroughbred yearling sales price in the UK.

Flow sensing on dragonfly wings (2024)
Journal Article
Uhrhan, M. J., Bomphrey, R. J., & Lin, H. (2024). Flow sensing on dragonfly wings. Annals of the New York Academy of Sciences, 1536(1), 107-121. https://doi.org/10.1111/nyas.15152

One feature of animal wings is their embedded mechanosensory system that can support flight control. Insect wings are particularly interesting as they are highly deformable yet the actuation is limited to the wing base. It is established that strain... Read More about Flow sensing on dragonfly wings.

Regenerative Medicine and Biological Treatments (2024)
Book Chapter
Guest, D., Schramme, M., & Smith, R. (2024). Regenerative Medicine and Biological Treatments. In Essential Facts of Equine Physical Therapy, Rehabilitation and Sports Medicine

Many tissues undergo poor natural regeneration following injury or disease and the reparative healing process can lead to tissues that are functionally inferior and prone to re-injury. Regenerative medicine aims to induce natural tissue regeneration... Read More about Regenerative Medicine and Biological Treatments.

Variations in touch representation in the hummingbird and zebra finch forebrain (2024)
Journal Article
Gaede, A., Wu, P., & Leitch, D. (2024). Variations in touch representation in the hummingbird and zebra finch forebrain. Current Biology, 34(12), https://doi.org/10.1016/j.cub.2024.04.081

Somatosensation is essential for animals to perceive the external world through touch, allowing them to detect physical contact, temperature, pain, and body position. Studies on rodent vibrissae have highlighted the organization and processing in mam... Read More about Variations in touch representation in the hummingbird and zebra finch forebrain.

Is badger culling associated with risk compensation behaviour among cattle farmers? (2024)
Journal Article
Brunton, L., & Enticott, G. (in press). Is badger culling associated with risk compensation behaviour among cattle farmers?. Veterinary Record, https://doi.org/10.1002/vetr.4152

Background
Risk compensation theory suggests that behaviours are modified in response to interventions that remove risks by substituting them with other risky behaviours to maintain a ‘risk equilibrium’. Alternatively, risk reduction interventions m... Read More about Is badger culling associated with risk compensation behaviour among cattle farmers?.

Large-scale statistical analysis of Mycobacterium tuberculosis genome sequences identifies compensatory mutations associated with multi-drug resistance (2024)
Journal Article
Billow, N., Phelan, J., Xia, D., Peng, Y., Clark, T. G., & Chang, Y.-M. (in press). Large-scale statistical analysis of Mycobacterium tuberculosis genome sequences identifies compensatory mutations associated with multi-drug resistance. Scientific Reports, https://doi.org/10.1038/s41598-024-62946-8

Tuberculosis (TB), caused by Mycobacterium tuberculosis, has a significant impact on global health worldwide. The development of multi-drug strains that are resistant to the first-line drugs isoniazid and rifampicin threatens public health security.... Read More about Large-scale statistical analysis of Mycobacterium tuberculosis genome sequences identifies compensatory mutations associated with multi-drug resistance.

Exposure to urban particulate matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response (2024)
Journal Article
Morris, R. H., Counsell, S. J., McGonnell, I. M., & Thornton, C. (in press). Exposure to urban particulate matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response. Journal of Physiology, https://doi.org/10.1113/jp285978

World Health Organisation data suggest that up to 99% of the global population are exposed to air pollutants above recommended levels. Impacts to health range from increased risk of stroke and cardiovascular disease to chronic respiratory conditions,... Read More about Exposure to urban particulate matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response.

Exposure to Urban Particulate Matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response (2024)
Journal Article
Morris, R., Counsell, S., McGonnell, I., & Thornton, C. (in press). Exposure to Urban Particulate Matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response. Journal of Physiology, https://doi.org/10.1113/JP285978

World Health Organisation data suggest that up to 99% of the global population are exposed to air pollutants above recommended levels. Impacts to health range from increased risk of stroke and cardiovascular disease to chronic respiratory conditions,... Read More about Exposure to Urban Particulate Matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response.

Re-evaluating the placebo response in recent canine dietary epilepsy trials (2024)
Journal Article
Schmidt, T., Meyerhoff, N., Meller, S., Twele, F., Charalambous, M., Berk, B., Law, T., Packer, R., Zanghi, B., Pan, Y., Fischer, A., & Volk, H. (2024). Re-evaluating the placebo response in recent canine dietary epilepsy trials. BMC Veterinary Research, 20(1), https://doi.org/10.1186/s12917-024-04066-z

The placebo response is a common phenomenon. Limited evidence is available about its magnitude in canine epilepsy trials, even though it can significantly influence the efficacy evaluation of new treatments. It was hypothesised that the placebo respo... Read More about Re-evaluating the placebo response in recent canine dietary epilepsy trials.

Epidemiology of heat-related illness in dogs under UK emergency veterinary care in 2022 (2024)
Journal Article
Beard, S., Hall, E. J., Bradbury, J., Carter, A. J., Gilbert, S., & O'Neill, D. G. (2024). Epidemiology of heat-related illness in dogs under UK emergency veterinary care in 2022. Herpetological Conservation and Biology, https://doi.org/10.1002/vetr.4153

Background: Dogs are exposed to increasing environmental risk for developing heat-related illness (HRI), with 2022 recorded as the hottest year to date in the UK and most of Europe. Methods: This study used VetCompass data to report the incidence ris... Read More about Epidemiology of heat-related illness in dogs under UK emergency veterinary care in 2022.

Researcher, research thyself? Mapping the landscape of canine health and welfare research funding provided by UK not-for-profit organisations from 2012–2022 (2024)
Journal Article
O'Neill, D., Skipper, A. M., & Packer, R. M. . A. (2024). Researcher, research thyself? Mapping the landscape of canine health and welfare research funding provided by UK not-for-profit organisations from 2012–2022. Herpetological Conservation and Biology, 19(5), e0303498. https://doi.org/10.1371/journal.pone.0303498

Background Research into canine health and welfare is supported by Government, charitable and private UK funding organisations. However, there is no current overall visibility or coordination of these funding activities, potentially compromising opti... Read More about Researcher, research thyself? Mapping the landscape of canine health and welfare research funding provided by UK not-for-profit organisations from 2012–2022.

Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy (2024)
Journal Article
Poupon-Bejuit, L., Geard, A., Millicheap, N., Rocha-Ferreira, E., Hagberg, H., Thornton, C., & Rahim, A. A. (2024). Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy. EMBO Molecular Medicine, https://doi.org/10.1038/s44321-024-00079-1

Hypoxic-ischaemic encephalopathy (HIE) arises from diminished blood flow and oxygen to the neonatal brain during labor, leading to infant mortality or severe brain damage, with a global incidence of 1.5 per 1000 live births. Glucagon-like Peptide 1 R... Read More about Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy.

Environmental Land Management scheme (ELMs) (2024)
Report
Myers, J., Whatford, L., Qi, A., Cooke, R., Payne-Gifford, S., Tak, M., van Winden, S., Barling, D., & Haesler, B. (2024). Environmental Land Management scheme (ELMs). not applicable

An unprecedented set of challenges now confronts livestock food systems in Britain. With household budgets being squeezed, producers, processors, retailers and wholesalers are under increasing pressure to maintain the affordability of their products... Read More about Environmental Land Management scheme (ELMs).

Animal Health and Welfare Pathway (AHWP) (2024)
Report
Payne-Gifford, S., Myers, J., Whatford, L., Tak, M., van Winden, S., Qi, A., Haesler, B., & Barling, D. (2024). Animal Health and Welfare Pathway (AHWP). RVC Research online: not applicable

An unprecedented set of challenges now confronts livestock food systems in Britain. With household budgets being squeezed, producers, processors, retailers and wholesalers are under increasing pressure to maintain the affordability of their products... Read More about Animal Health and Welfare Pathway (AHWP).