Skip to main content

Research Repository

Advanced Search

All Outputs (69)

Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum (2020)
Journal Article
Regidor-Cerrillo, J., Xia, D., Jiménez-Pelayo, L., García-Sánchez, M., Collantes-Fernández, E., Randle, N., …Horcajo, P. (2020). Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum. Pathogens, 9(9), 749

Despite the importance of bovine neosporosis, relevant knowledge gaps remain concerning the pathogenic mechanisms of Neospora caninum. Infection of the placenta is a crucial event in the pathogenesis of the disease; however, very little is known abou... Read More about Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum.

Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by (2020)
Journal Article
Regidor-Cerrillo, J., Xia, D., Jiménez-Pelayo, L., García-Sánchez, M., Collantes-Fernández, E., Randle, N., …Horcajo, P. (2020). Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by. Pathogens, 9(9),

Despite the importance of bovine neosporosis, relevant knowledge gaps remain concerning the pathogenic mechanisms of . Infection of the placenta is a crucial event in the pathogenesis of the disease; however, very little is known about the relation... Read More about Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by.

Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration. (2020)
Journal Article
Faccenda, D., & Campanella, M. (2020). Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration. Journal of Neuroimmune Pharmacology,

Mitochondrial dysfunction occurs in most neurodegenerative diseases, contributing to both their onset and progression. A recent breakthrough unveiled that propagation of the inflammatory response and subsequent neuronal injury are also mediated extra... Read More about Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration..

Biomechanics of the mandible of Macaca mulatta during the power stroke of mastication: Loading, deformation, and strain regimes and the impact of food type (2020)
Journal Article
Panagiotopoulou, O., Iriarte-Diaz, J., Mehari Abraha, H., Taylor, A. B., Wilshin, S., Dechow, P. C., & Ross, C. F. (2020). Biomechanics of the mandible of Macaca mulatta during the power stroke of mastication: Loading, deformation, and strain regimes and the impact of food type. Journal of Human Evolution, 147, 102865. https://doi.org/10.1016/j.jhevol.2020.102865

Mandible morphology has yet to yield definitive information on primate diet, probably because of poor understanding of mandibular loading and strain regimes, and overreliance on simple beam models of mandibular mechanics. We used a finite element mod... Read More about Biomechanics of the mandible of Macaca mulatta during the power stroke of mastication: Loading, deformation, and strain regimes and the impact of food type.

Evolution of the patella and patelloid in marsupial mammals (2020)
Journal Article
Denyer, A. L., Regnault, S., & Hutchinson, J. R. (2020). Evolution of the patella and patelloid in marsupial mammals. PeerJ, 8, e9760

The musculoskeletal system of marsupial mammals has numerous unusual features beyond the pouch and epipubic bones. One example is the widespread absence or reduction (to a fibrous “patelloid”) of the patella (“kneecap”) sesamoid bone, but prior studi... Read More about Evolution of the patella and patelloid in marsupial mammals.

Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse (2020)
Journal Article
Shilton, C. A., Kahler, A., Davis, B. W., Crabtree, J. R., Crowhurst, J., McGladdery, A. J., …de Mestre, A. M. (2020). Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-69967-z

The first 8 weeks of pregnancy is a critical time, with the majority of pregnancy losses occurring during this period. Abnormal chromosome number (aneuploidy) is a common finding in human miscarriage, yet is rarely reported in domestic animals. Equin... Read More about Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse.

Artificial mass loading disrupts stable social order in pigeon dominance hierarchies (2020)
Journal Article
Portugal, S. J., Usherwood, J. R., White, C. R., Sankey, D. W. E., & Wilson, A. M. (2020). Artificial mass loading disrupts stable social order in pigeon dominance hierarchies. Biology Letters, 16(8), 20200468

Dominance hierarchies confer benefits to group members by decreasing the incidences of physical conflict, but may result in certain lower ranked individuals consistently missing out on access to resources. Here, we report a linear dominance hierarchy... Read More about Artificial mass loading disrupts stable social order in pigeon dominance hierarchies.

Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus (2020)
Journal Article
Faulkner, A., Tamiato, A., Cathery, W., Rampin, A., Caravaggi, C. M., Jover, E., …Madeddu, P. (2020). Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus. Diabetologia, 63(10), 2205-2217

Aims/hypothesis Treatment of vascular complications of diabetes remains inadequate. We reported that muscle pericytes (MPs) from limb muscles of vascular patients with diabetes mellitus display elevated levels of oxidative stress causing a dysfunctio... Read More about Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus.

Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells (2020)
Journal Article
Shah, M., Maroof, A., Gikas, P., Mittal, G., Keen, R., Baeten, D., …Roberts, S. J. (2020). Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells. RMD Open, 6(2), e001306. https://doi.org/10.1136/rmdopen-2020-001306

Objectives Interleukin (IL)-17 signalling has been shown to be a key regulator of disease in ankylosing spondylitis (AS) with several IL-17 blockers currently clinically approved. Despite this, the role of IL-17 in bone pathology is poorly understo... Read More about Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells.

Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors (2020)
Journal Article
Bingor, A., Haham, T., Thornton, C., Stern-Bach, Y., & Yaka, R. (2020). Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors. Nature Communications, 11(1), https://doi.org/10.1038/s41467-020-17484-y

Zeta inhibitory peptide (ZIP), a PKMζ inhibitor, is widely used to interfere with the main- tenance of acquired memories. ZIP is able to erase memory even in the absence of PKMζ, via an unknown mechanism. We found that ZIP induces redistribution of t... Read More about Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors.

Emerging Roles for Neuropilin-2 in Cardiovascular Disease (2020)
Journal Article
Harman, J. L., Sayers, J., Chapman, C., & Pellet-Many, C. (2020). Emerging Roles for Neuropilin-2 in Cardiovascular Disease. International Journal of Molecular Sciences, 21(14), 5154. https://doi.org/10.3390/ijms21145154

Cardiovascular disease, the leading cause of death worldwide, is predominantly associated with atherosclerosis. Atherosclerosis is a chronic inflammatory disease characterised by the narrowing of large to medium-sized arteries due to a build-up of pl... Read More about Emerging Roles for Neuropilin-2 in Cardiovascular Disease.

Pilot study assessing the use of cabergoline for the treatment of cats with hypersomatotropism and diabetes mellitus (2020)
Journal Article
Scudder, C. J., Hazuchova, K., Gostelow, R., Church, D. B., Forcada, Y., Fowkes, R. C., & Niessen, S. J. M. (2020). Pilot study assessing the use of cabergoline for the treatment of cats with hypersomatotropism and diabetes mellitus. Journal of Feline Medicine and Surgery, 1098612X2093321. https://doi.org/10.1177/1098612X20933213

Abstract Objectives An affordable and effective treatment is needed to manage feline hypersomatotropism. The aim of this study was to assess whether treatment with oral cabergoline for 90 days in cats with hypersomatotropism and diabetes mellitus i... Read More about Pilot study assessing the use of cabergoline for the treatment of cats with hypersomatotropism and diabetes mellitus.

Microporous Biodegradable Films Promote Therapeutic Angiogenesis (2020)
Journal Article
Hendow, E., Moazen, M., Iacoviello, F., Bozec, L., Pellet‐Many, C., & Day, R. (2020). Microporous Biodegradable Films Promote Therapeutic Angiogenesis. Advanced Healthcare Materials, 2000806

Peripheral arterial disease and critical limb ischemia are common symptoms of cardiovascular disease. Vascular surgery is used to create a bypass around occluded blood vessels to improve blood flow to ischemic muscle, thus avoiding the need for amput... Read More about Microporous Biodegradable Films Promote Therapeutic Angiogenesis.

Bimodal Whole-Mount Imaging of Tendon Using Confocal Microscopy and X-ray Micro-Computed Tomography (2020)
Journal Article
Marr, N., Hopkinson, M., Hibbert, A., Pitsillides, A., & Thorpe, C. (2020). Bimodal Whole-Mount Imaging of Tendon Using Confocal Microscopy and X-ray Micro-Computed Tomography. Biological Procedures Online, https://doi.org/10.1186/s12575-020-00126-4

BACKGROUND:3-dimensional imaging modalities for optically dense connective tissues such as tendons are limited and typically have a single imaging methodological endpoint. Here, we have developed a bimodal procedure utilising fluorescence-based confo... Read More about Bimodal Whole-Mount Imaging of Tendon Using Confocal Microscopy and X-ray Micro-Computed Tomography.

β-catenin promotes endothelial survival by regulating eNOS activity and flow-dependent anti-apoptotic gene expression (2020)
Journal Article
Tajadura, V., Hansen, M. H., Smith, J., Charles, H., Rickman, M., Farrell-Dillon, K., …Ferro, A. (2020). β-catenin promotes endothelial survival by regulating eNOS activity and flow-dependent anti-apoptotic gene expression. Cell Death and Disease, 11(6), https://doi.org/10.1038/s41419-020-2687-6

Increased endothelial cell (EC) apoptosis is associated with the development of atherosclerotic plaques that develop predominantly at sites exposed to disturbed flow (DF). Strategies to promote EC survival may therefore represent a novel therapeutic a... Read More about β-catenin promotes endothelial survival by regulating eNOS activity and flow-dependent anti-apoptotic gene expression.

Analysis of teaching methods in anaesthesia in the undergraduate curriculum of 4 veterinary universities (2020)
Journal Article
D'Anselme, O., Pelligand, L., Veres-Nyeki, K. O., Zaccagnini, A., & Zilberstein, L. (2020). Analysis of teaching methods in anaesthesia in the undergraduate curriculum of 4 veterinary universities. Veterinary Anaesthesia and Analgesia,

Objectives: There are no standardized methods for teaching anaesthesia in veterinary universities. Our aims were 1) design a holistic audit tool to assess anaesthesia teaching strategies in veterinary universities; 2) to apply the tool to 4 veterina... Read More about Analysis of teaching methods in anaesthesia in the undergraduate curriculum of 4 veterinary universities.

The chemokine CXCL16 can rescue the defects in insulin signaling and sensitivity caused by palmitate in C2C12 myotubes (2020)
Journal Article
Bitsi, S. (2020). The chemokine CXCL16 can rescue the defects in insulin signaling and sensitivity caused by palmitate in C2C12 myotubes. Cytokine, 133, 155154. https://doi.org/10.1016/j.cyto.2020.155154

In obesity, macrophages infiltrate peripheral tissues and secrete pro-inflammatory cytokines that impact local insulin sensitivity. Lipopolysaccharide (LPS) and the saturated fatty acid (FA) palmitate polarise macrophages towards a pro-inflammatory p... Read More about The chemokine CXCL16 can rescue the defects in insulin signaling and sensitivity caused by palmitate in C2C12 myotubes.

Mapping human serum–induced gene networks as a basis for the creation of biomimetic periosteum for bone repair (2020)
Journal Article
Al Hosni, R., Shah, M., Cheema, U., Roberts, H., Luyten, F., & Roberts, S. (2020). Mapping human serum–induced gene networks as a basis for the creation of biomimetic periosteum for bone repair. Cytotherapy,

The periosteum is a highly vascularised, collagen-rich tissue that plays a crucial role in directing bone repair. This is orchestrated primarily by its resident progenitor cell population. Indeed, preservation of periosteum integrity is critical for... Read More about Mapping human serum–induced gene networks as a basis for the creation of biomimetic periosteum for bone repair.

The Possibility of Zero Limb-Work Gaits in Sprawled and Parasagittal Quadrupeds: Insights from Linkages of the Industrial Revolution (2020)
Journal Article
Usherwood, J. R. (2020). The Possibility of Zero Limb-Work Gaits in Sprawled and Parasagittal Quadrupeds: Insights from Linkages of the Industrial Revolution. Integrative Organismal Biology, 2(1),

Animal legs are diverse, complex, and perform many roles. One defining requirement of legs is to facilitate terrestrial travel with some degree of economy. This could, theoretically, be achieved without loss of mechanical energy if the body could tak... Read More about The Possibility of Zero Limb-Work Gaits in Sprawled and Parasagittal Quadrupeds: Insights from Linkages of the Industrial Revolution.