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Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection (2019)
Journal Article
Koring, G., Leverin, A. L., Nair, S., Schwendimann, L., Ek, J., Carlsson, Y., …Hagberg, H. (2019). Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection. https://doi.org/10.1177/0271678X17746132

Magnesium sulphate (MgSO4) given to women in preterm labor reduces cerebral palsy in their offspring but the mechanism behind this protection is unclear, limiting its effective, safe clinical implementation. Previous studies suggest that MgSO4 is not... Read More about Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection.

Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannheimia haemolytica and Pasteurella multocida in three growth media (2019)
Journal Article
Mead, A., Lees, P., Mitchell, J., Rycroft, A. N., Standing, J. F., Toutain, P. L., & Pelligand, L. (2019). Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannheimia haemolytica and Pasteurella multocida in three growth media. Journal of Veterinary Pharmacology and Therapeutics, 42(1), 52-59. https://doi.org/10.1111/jvp.12719

For clinical isolates of bovine Mannheimia haemolytica and Pasteurella multocida, this study reports minimum inhibitory concentration (MIC) differences for tetracycline, oxytetracycline and doxycycline between cation‐adjusted Mueller‐Hinton broth (CA... Read More about Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannheimia haemolytica and Pasteurella multocida in three growth media.

Pituitary pathology and gene expression in acromegalic cats (2019)
Journal Article
Scudder, C. J., Mirczuk, S. M., Richardson, K. M., Crossley, V. J., Regan, J. T. C., Gostelow, R., …Niessen, S. J. M. (2019). Pituitary pathology and gene expression in acromegalic cats. Journal of the Endocrine Society, 3(1), 181-200. https://doi.org/10.1210/js.2018-00226

The prevalence of growth hormone secreting pituitary tumours in domestic cats (Felis catus) is ten times greater than in humans. The predominant inhibitory receptors of growth hormone-secreting pituitary tumours are somatostatin receptors (SSTRs) and... Read More about Pituitary pathology and gene expression in acromegalic cats.

The locomotor kinematics and ground reaction forces of walking giraffes. (2019)
Journal Article
Basu, C. K., Wilson, A. M., & Hutchinson, J. R. (2019). The locomotor kinematics and ground reaction forces of walking giraffes. Journal of Experimental Biology, 222(22), https://doi.org/10.1242/jeb.159277

Giraffes (Giraffa camelopardalis Linnaeus 1758) possess specialised anatomy. Their disproportionately elongate limbs and neck confer recognised feeding advantages, but little is known about how their morphology affects locomotor function. In this stu... Read More about The locomotor kinematics and ground reaction forces of walking giraffes..

An Overview on Principles for Energy Efficient Robot Locomotion (2018)
Journal Article
Kashiri, N., Abate, A., Abram, S. J., Albu-Schaffer, A., Clary, P. J., Daley, M. A., …Tsagarakis, N. (2018). An Overview on Principles for Energy Efficient Robot Locomotion. Frontiers in Robotics and AI, 5(129), https://doi.org/10.3389/frobt.2018.00129

Despite enhancements in the development of robotic systems, the energy economy of today's robots lags far behind that of biological systems. This is in particular critical for untethered legged robot locomotion. To elucidate the current stage of ener... Read More about An Overview on Principles for Energy Efficient Robot Locomotion.

Decreased nematode clearance & anti-phosphorylcholine specific IgM responses in mannose-binding lectin deficient mice (2018)
Journal Article
Ahmed, R., Cadman, E. T., Snapper, C. M., & Lawrence, R. A. (2018). Decreased nematode clearance & anti-phosphorylcholine specific IgM responses in mannose-binding lectin deficient mice. https://doi.org/10.1111/imcb.12219

Brugia malayi is a nematode that causes human lymphatic filariasis. Previously, we showed that mannose binding lectin (MBL) ‐A is necessary for clearance of B. malayi microfilariae in mice and presence of MBL‐A is linked with maximal levels of parasi... Read More about Decreased nematode clearance & anti-phosphorylcholine specific IgM responses in mannose-binding lectin deficient mice.

Patterns of microchromosome organization remain highly conserved throughout avian evolution (2018)
Journal Article
O'Connor, R. E., Kiazim, L., Skinner, B., Fonseka, G., Joseph, S., Jennings, R., & Larkin, D. M. (2018). Patterns of microchromosome organization remain highly conserved throughout avian evolution. Chromosoma, 128(1), 21-29. https://doi.org/10.1007/s00412-018-0685-6

The structure and organization of a species genome at a karyotypic level, and in interphase nuclei, have broad functional significance. Although regular sized chromosomes are studied extensively in this regard, microchromosomes, which are present in... Read More about Patterns of microchromosome organization remain highly conserved throughout avian evolution.

Genomes of trombidid mites reveal novel predicted allergens and laterally-transferred genes associated with secondary metabolism (2018)
Journal Article
Dong, X., Chaisiri, K., Xia, D., Armstrong, S. D., Fang, Y., Donnelly, M. J., …Makepeace, B. L. (2018). Genomes of trombidid mites reveal novel predicted allergens and laterally-transferred genes associated with secondary metabolism. GigaScience, 7(12), https://doi.org/10.1093/gigascience/giy127

Trombidid mites have a unique lifecycle in which only the larval stage is ectoparasitic. In the superfamily Trombiculoidea (“chiggers”), the larvae feed preferentially on vertebrates, including humans. Species in the genus Leptotrombidium are vectors... Read More about Genomes of trombidid mites reveal novel predicted allergens and laterally-transferred genes associated with secondary metabolism.

Meridianin C inhibits the growth of YD-10B human tongue cancer cells through macropinocytosis and the down-regulation of Dickkopf-related protein-3 (2018)
Journal Article
Park, N. S., Park, Y. K., Ramalingam, M., Yadav, A. K., Cho, H. R., Hong, V. S., …Jang, B. C. (2018). Meridianin C inhibits the growth of YD-10B human tongue cancer cells through macropinocytosis and the down-regulation of Dickkopf-related protein-3. Journal of Cellular and Molecular Medicine, 22(12), 5833-5846. https://doi.org/10.1111/jcmm.13854

Meridianin C is a marine natural product known for its anti‐cancer activity. At present, the anti‐tumour effects of meridianin C on oral squamous cell carcinoma are unknown. Here, we investigated the effect of meridianin C on the proliferation of fou... Read More about Meridianin C inhibits the growth of YD-10B human tongue cancer cells through macropinocytosis and the down-regulation of Dickkopf-related protein-3.

Dysregulated cancer cell transdifferentiation into erythrocytes is an additional metabolic stress in hepatocellular carcinoma (2018)
Journal Article
Hughes, A., & Dhoot, G. K. (2018). Dysregulated cancer cell transdifferentiation into erythrocytes is an additional metabolic stress in hepatocellular carcinoma. Tumor Biology, 40(11), https://doi.org/10.1177/1010428318811467

A number of human and canine hepatocellular carcinoma tissues showed clear signs of hypoxia indicated by HIF1α-activation and the presence of large clusters of cells resembling erythrocytes at different stages of nuclear elimination without any defin... Read More about Dysregulated cancer cell transdifferentiation into erythrocytes is an additional metabolic stress in hepatocellular carcinoma.

Anatomy Teaching, a “Model” Answer? Evaluating “Geoff”, a Painted Anatomical Horse, as a Tool for Enhancing Topographical Anatomy Learning (2018)
Journal Article
Bietzk, E., Weller, R., Simons, V., & Channon, S. B. (2018). Anatomy Teaching, a “Model” Answer? Evaluating “Geoff”, a Painted Anatomical Horse, as a Tool for Enhancing Topographical Anatomy Learning. Anatomical Sciences Education, https://doi.org/10.1002/ase.1823

Development of new methods for anatomy teaching is increasingly important as we look to modernize and supplement traditional teaching methods. In this study, a life‐sized equine model, “Geoff” was painted with surface and deep anatomical structures w... Read More about Anatomy Teaching, a “Model” Answer? Evaluating “Geoff”, a Painted Anatomical Horse, as a Tool for Enhancing Topographical Anatomy Learning.

Cancellous bone and theropod dinosaur locomotion. Part II—a new approach to inferring posture and locomotor biomechanics in extinct tetrapod vertebrates (2018)
Journal Article
Bishop, P. J., Hocknull, S. A., Clemente, C. J., Hutchinson, J. R., Barrett, R. S., & Lloyd, D. G. (2018). Cancellous bone and theropod dinosaur locomotion. Part II—a new approach to inferring posture and locomotor biomechanics in extinct tetrapod vertebrates. PeerJ, 6, e5779. https://doi.org/10.7717/peerj.5779

This paper is the second of a three-part series that investigates the architecture of cancellous bone in the main hindlimb bones of theropod dinosaurs, and uses cancellous bone architectural patterns to infer locomotor biomechanics in extinct non-avi... Read More about Cancellous bone and theropod dinosaur locomotion. Part II—a new approach to inferring posture and locomotor biomechanics in extinct tetrapod vertebrates.

Cancellous bone and theropod dinosaur locomotion. Part III—Inferring posture and locomotor biomechanics in extinct theropods, and its evolution on the line to birds (2018)
Journal Article
Bishop, P. J., Hocknull, S. A., Clemente, C. J., Hutchinson, J. R., Farke, A. A., Beck, B. R., …Lloyd, D. G. (2018). Cancellous bone and theropod dinosaur locomotion. Part III—Inferring posture and locomotor biomechanics in extinct theropods, and its evolution on the line to birds. PeerJ, 6, e5777. https://doi.org/10.7717/peerj.5777

This paper is the last of a three-part series that investigates the architecture of cancellous bone in the main hindlimb bones of theropod dinosaurs, and uses cancellous bone architectural patterns to infer locomotor biomechanics in extinct non-avian... Read More about Cancellous bone and theropod dinosaur locomotion. Part III—Inferring posture and locomotor biomechanics in extinct theropods, and its evolution on the line to birds.

Cancellous bone and theropod dinosaur locomotion. Part I—an examination of cancellous bone architecture in the hindlimb bones of theropods (2018)
Journal Article
Bishop, P. J., Hocknull, S. A., Clemente, C. J., Hutchinson, J. R., Farke, A. A., Beck, B. R., …Lloyd, D. G. (2018). Cancellous bone and theropod dinosaur locomotion. Part I—an examination of cancellous bone architecture in the hindlimb bones of theropods. PeerJ, 6, e5778. https://doi.org/10.7717/peerj.5778

This paper is the first of a three-part series that investigates the architecture of cancellous (‘spongy’) bone in the main hindlimb bones of theropod dinosaurs, and uses cancellous bone architectural patterns to infer locomotor biomechanics in extin... Read More about Cancellous bone and theropod dinosaur locomotion. Part I—an examination of cancellous bone architecture in the hindlimb bones of theropods.