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All Outputs (108)

Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing (2018)
Journal Article
Attig, J., Agostini, F., Gooding, C., Chakrabarti, A. M., Singh, A., Haberman, N., Zagalak, J. A., Emmett, W., Smith, C. W. J., Luscombe, N. M., & Ule, J. (2018). Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing. Cell, https://doi.org/10.1016/j.cell.2018.07.001

Long mammalian introns make it challenging for the RNA processing machinery to identify exons accurately. We find that LINE-derived sequences (LINEs) contribute to this selection by recruiting dozens of RNA-binding proteins (RBPs) to introns. This in... Read More about Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing.

Uncovering the structure of the mouse gait controller: mice respond to substrate perturbations with adaptations in gait on a continuum between trot and bound (2018)
Journal Article
Vahedipour, A., Haji Maghsoudi, O., Wilshin, S., Shamble, P., Robertson, B., & Spence, A. (2018). Uncovering the structure of the mouse gait controller: mice respond to substrate perturbations with adaptations in gait on a continuum between trot and bound. Journal of Biomechanics, 78(10), 77-86. https://doi.org/10.1016/j.jbiomech.2018.07.020

Alteration in the expression of the renin-angiotensin system in the myocardium of mice conceived by in vitro fertilization (2018)
Journal Article
Wang, Q., Zhang, Y., Le, F., Wang, N., Zhang, F., Luo, Y., Lou, Y., Hu, M., Wang, L., Thurston, L. M., Xu, X., & Jin, F. (2018). Alteration in the expression of the renin-angiotensin system in the myocardium of mice conceived by in vitro fertilization. Biology of Reproduction, https://doi.org/10.1093/biolre/ioy158

Epidemiological studies have revealed that offspring conceived by in vitro fertilization (IVF) have an elevated risk of cardiovascular malformations at birth, and are more predisposed to cardiovascular diseases in late childhood. Unfortunately, the u... Read More about Alteration in the expression of the renin-angiotensin system in the myocardium of mice conceived by in vitro fertilization.

Dynamic changes in gene expression and signalling during trophoblast development in the horse (2018)
Journal Article
Read, J. E., Cabrera-Sharp, V., Offord, V., Mirczuk, S. M., Allen, S. P., Fowkes, R. C., & De Mestre, A. M. (2018). Dynamic changes in gene expression and signalling during trophoblast development in the horse. Reproduction, 156(4), 313-330. https://doi.org/10.1530/REP-18-0270

Equine chorionic girdle trophoblast cells play important endocrine and immune functions critical in supporting pregnancy. Very little is known about the genes and pathways that regulate chorionic girdle trophoblast development. Our aim was to identif... Read More about Dynamic changes in gene expression and signalling during trophoblast development in the horse.

Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation (2018)
Journal Article
Gage, M. C., Becares, N., Louie, R., Waddington, K. E., Zhang, Y., Tittanegro, T. H., Rodriguez-Lorenzo, S., Jathanna, A., Pourcet, B., Pello, O., De La Rosa, J. V., Castrillo, A., & Pineda-Torra, I. (2018). Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. Proceedings of the National Academy of Sciences, 115(28), E6556-E6565. https://doi.org/10.1073/pnas.1721245115

Macrophages are key immune cells for the initiation and development of atherosclerotic lesions. However, the macrophage regulatory nodes that determine how lesions progress in response to dietary challenges are not fully understood. Liver X receptors... Read More about Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.

Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation (2018)
Journal Article
Gage, M. C., Becares, N., Louie, R., Waddington, K. E., Zhang, Y., Tittanegro, T. H., Rodriguez-Lorenzo, S., Jathanna, A., Pourcet, B., Pello, O., De La Rosa, J. V., Castrillo, A., & Pineda-Torra, I. (2018). Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. https://doi.org/10.1073/pnas.1721245115

Macrophages are key immune cells for the initiation and development of atherosclerotic lesions. However, the macrophage regulatory nodes that determine how lesions progress in response to dietary challenges are not fully understood. Liver X receptors... Read More about Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.

Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies (2018)
Journal Article
Finding, E. J. T., Lawson, C., Elliott, J., Harris, P. A., & Menzies-Gow, N. J. (2018). Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies. Veterinary Immunology and Immunopathology, https://doi.org/10.1016/j.vetimm.2018.06.001

Microvesicles are small (up to 1 μm) vesicles found in plasma and other bodily fluids. They are recognised as part of the normal system of inter-cellular communication but altered numbers are also used as biomarkers of disease. Microvesicles have not... Read More about Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies.

Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies (2018)
Journal Article
Timpson, A., De Mestre, A. M., Elliott, J., Harris, P. A., Cheng, Z. R., Mirczuk, S. M., Callan, L., Rainbow, L., & Menzies-Gow, N. J. (2018). Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies. Journal of Equine Veterinary Science, https://doi.org/10.1016/j.jevs.2018.06.009

The aims of the study were to determine whether adipose tissue global gene expression (i) differs between never laminitic (NL) and previously laminitic (PL) ponies; (ii) is influenced by season and/or a diet designed to simulate spring grass and (iii... Read More about Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies.

Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly (2018)
Journal Article
Rando, H., Farré, M., Robson, M., Won, N., Johnson, J., Buch, R., Bastounes, E., Xiang, X., Feng, S., Liu, S., Xiong, Z., Kim, J., Zhang, G., Trut, L., Larkin, D. M., & Kukekova, A. (2018). Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly. Genes, 9(6), 308. https://doi.org/10.3390/genes9060308

The genome of a red fox (Vulpes vulpes) was recently sequenced and assembled using next-generation sequencing (NGS). The assembly is of high quality, with 94X coverage and a scaffold N50 of 11.8 Mbp, but is split into 676,878 scaffolds, some of which... Read More about Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly.

A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping (2018)
Journal Article
Richards, C. T., & Porro, L. B. (2018). A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping. Journal of Theoretical Biology, 454, 410-424. https://doi.org/10.1016/j.jtbi.2018.06.010

Spherical Linear Interpolation (SLERP) has long been used in computer animation to interpolate movements between two 3D orientations. We developed a forward kinematics (FK) approach using quaternions and SLERP to predict how frogs modulate jump kinem... Read More about A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping.

Understanding the agility of running birds: Sensorimotor and mechanical factors in avian bipedal locomotion (2018)
Journal Article
Daley, M. A. (2018). Understanding the agility of running birds: Sensorimotor and mechanical factors in avian bipedal locomotion. Integrative and Comparative Biology, https://doi.org/10.1093/icb/icy058

Birds are a diverse and agile lineage of vertebrates that all use bipedal locomotion for at least part of their life. Thus birds provide a valuable opportunity to investigate how biomechanics and sensorimotor control are integrated for agile bipedal... Read More about Understanding the agility of running birds: Sensorimotor and mechanical factors in avian bipedal locomotion.

a-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease (2018)
Journal Article
Ludtmann, M. H. R., Angelova, P. R., Horrocks, M. H., Choi, M. L., Rodrigues, M., Baev, A. Y., Berezhnov, A. V., Yao, Z., Little, D., Banushi, B., Al-Menhali, A. S., Ranasinghe, R. T., Whiten, D. R., Yapom, R., Dolt, K. S., Devine, M. J., Gissen, P., Kunath, T., Jaganjac, M., Pavlov, E. V., …Gandhi, S. (2018). a-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease. Nature Communications, 9, 2293. https://doi.org/10.1038/s41467-018-04422-2

Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency. Here, we report that aggregation of monomer... Read More about a-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease.

Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates (2018)
Journal Article
Martin-Jimenez, R., Faccenda, D., Allen, E., Reichel, H. B., Arcos, L., Ferraina, C., Strobbe, D., Russell, C., & Campanella, M. (2018). Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates. https://doi.org/10.1038/s41419-018-0578-x

In vertebrates, mitochondria are tightly preserved energy producing organelles, which sustain nervous system development and function. The understanding of proteins that regulate their homoeostasis in complex animals is therefore critical and doing s... Read More about Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates.

Integrative transcriptome and proteome analyses define marked differences between Neospora caninum isolates throughout the tachyzoite lytic cycle (2018)
Journal Article
Horcajo, P., Xia, D., Randle, N., Collantes-Fernández, E., Wastling, J., Ortega-Mora, L. M., & Regidor-Cerrillo, J. (2018). Integrative transcriptome and proteome analyses define marked differences between Neospora caninum isolates throughout the tachyzoite lytic cycle. Journal of Proteomics, 180, 108-119. https://doi.org/10.1016/j.jprot.2017.11.007

Neospora caninum is one of the main causes of transmissible abortion in cattle. Intraspecific variations in virulence have been widely shown among N. caninum isolates. However, the molecular basis governing such variability have not been elucidated t... Read More about Integrative transcriptome and proteome analyses define marked differences between Neospora caninum isolates throughout the tachyzoite lytic cycle.

Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation (2018)
Journal Article
Martinez, M., Gehring, R., Mochel, J. P., Pade, D., & Pelligand, L. (2018). Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation. Journal of Veterinary Pharmacology and Therapeutics, 41(4), E-68. https://doi.org/10.1111/jvp.12666

During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the source... Read More about Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation.