Why the racing industry and equestrian disciplines need to implement population pharmacokinetics: To learn, explain, summarize, harmonize, and individualize
(2024)
Journal Article
Toutain, P. (2024). Why the racing industry and equestrian disciplines need to implement population pharmacokinetics: To learn, explain, summarize, harmonize, and individualize. Drug Testing and Analysis, https://doi.org/10.1002/dta.3706
All Outputs (6)
Reply to: Letter to the Editor from Malik et al: Acute kidney injury following subcutaneous meloxicam administration (2024)
Journal Article
Pelligand, L., King, J., Stapleton, N., D'Arcy-Howard, D., Elliott, J., & Krekis, A. (in press). Reply to: Letter to the Editor from Malik et al: Acute kidney injury following subcutaneous meloxicam administration. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13438
Control of a sulfadoxine/trimethoprim combination in the competition horse: Elimination, metabolism and detection following an intravenous administration (2023)
Journal Article
Schenk, I., Broussou, D., Roques, B., Lagershausen, H., Machnik, M., Röttgen, H., Toutain, P., & Thevis, M. (2023). Control of a sulfadoxine/trimethoprim combination in the competition horse: Elimination, metabolism and detection following an intravenous administration. Drug Testing and Analysis, https://doi.org/10.1002/dta.3461
Doxycycline serum protein binding in pigs reveals a relatively high free fraction (2023)
Journal Article
Felipe Ramon, P., Marlène Z., L., Béatrice B., R., Véronique, G., Pierre-Louis, T., & Bousquet-Mélou, A. (2023). Doxycycline serum protein binding in pigs reveals a relatively high free fraction. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13111Doxycycline is an antibiotic widely used in pig farming, which leads to update the doses using PK/PD concepts. However, there is an impasse to estimate the PK/PD cut-off of doxycycline in pigs. Indeed, considering its 7% free fraction and the total s... Read More about Doxycycline serum protein binding in pigs reveals a relatively high free fraction.
Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations (2022)
Journal Article
Kuroda, T., Minamijima, Y., Mita, H., Tamura, N., Fukuda, K., Kuwano, A., Toutain, P., & Sato, F. (2022). Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13099A pharmacokinetics/pharmacodynamics (PK/PD) approach was used to determine
the best empirical dosage regimen of cefazolin (CEZ) after intramuscular (IM) administration
of CEZ in horses. Seven horses received a single IM or intravenous (IV) administ... Read More about Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations.
A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients (2021)
Journal Article
Bousquet-Mélou, A., Lespine, A., Sutra, J.-F., Bargues, I., & Toutain, P.-L. (2021). A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients. Frontiers in Pharmacology, https://doi.org/10.3389/fphar.2021.666348Ivermectin (IVM) and moxidectin (MOX) are used extensively as parasiticides in veterinary medicine. Based on in vitro data, IVM has recently been proposed for the prevention and treatment of COVID-19 infection, a condition for which obesity is a majo... Read More about A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients.