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All Outputs (107)

Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis) (2024)
Journal Article
Martí-García, B., Priestnall, S., Torres, Y., & Suárez-Bonnet, A. (2024). Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis). Laboratory Animals, https://doi.org/10.1177/00236772241273060

Three seven-year-old African clawed frogs (Xenopus laevis) from an animal research facility showed weight loss, coelomic distention and an abnormal swimming gait were euthanised on welfare grounds. A complete necropsy of each animal showed a focal, f... Read More about Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis).

Computed tomographic findings of a nasal neuroendocrine neoplasm with intracranial extension in a horse (2024)
Journal Article
Giorio, M., Mitchell, J., Priestnall, S., Dunkel, B., Dash, R., & Berner, D. (2024). Computed tomographic findings of a nasal neuroendocrine neoplasm with intracranial extension in a horse. Equine Veterinary Education, https://doi.org/10.1111/eve.14040

A 20-year-old Irish Sport Horse gelding was presented to the Royal Veterinary College Equine Referral Hospital for investigation of left-sided epistaxis, depression and gait abnormalities of approximately 1 month duration. Physical examination and cr... Read More about Computed tomographic findings of a nasal neuroendocrine neoplasm with intracranial extension in a horse.

CD117 expression in canine ovarian tumours (2024)
Journal Article
Mallon, H., Ramírez, G., Dolensek, T., Erles, K., Martí-Garcia, B., Priestnall, S., & Suárez-Bonnet, A. (2024). CD117 expression in canine ovarian tumours. Journal of Comparative Pathology, 212, 1-5. https://doi.org/10.1016/j.jcpa.2024.05.001

Canine ovarian cancer poses a significant diagnostic and therapeutic challenge. The heterogeneous nature of ovarian tumours makes accurate histological identification difficult, whilst treatment is limited to surgical excision. The tyrosine kinase re... Read More about CD117 expression in canine ovarian tumours.

Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity (2024)
Journal Article
Then, C., Paillas, S., Moomin, A., Misheva, M., Moir, R., Hay, S., Bremner, D., Roberts, K., Smith, E., Heidari, Z., Sescu, D., Wang, X., Suárez-Bonnet, A., Hay, N., Murdoch, S., Saito, R., Collie-Duguid, E., Richardson, S., Priestnall, S., Wilson, J., …Kiltie, A. (2024). Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity. Microbiome, 12(1), https://doi.org/10.1186/s40168-024-01804-1

Background Non-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings showing that high-fibre diets sensitised bladder tumours to irradiation by modifying the gut microbiota... Read More about Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity.

Endothelial AHR activity prevents lung barrier disruption in viral infection (2023)
Journal Article
Major, J., Crotta, S., Finsterbusch, K., Chakravarty, P., Shah, K., Frederico, B., D'Antuono, R., Green, M., Meader, L., Suarez-Bonnet, A., Priestnall, S., Stockinger, B., & Wack, A. (2023). Endothelial AHR activity prevents lung barrier disruption in viral infection. Nature, https://doi.org/10.1038/s41586-023-06287-y

Disruption of the lung endothelial-epithelial cell barrier following respiratory virus infection causes cell and fluid accumulation in the air spaces and compromises vital gas exchange function(1). Endothelial dysfunction can exacerbate tissue damage... Read More about Endothelial AHR activity prevents lung barrier disruption in viral infection.

One Health Approach: Invasive California Kingsnake (Lampropeltis californiae) as an Important Source of Antimicrobial Drug-Resistant Salmonella Clones on Gran Canaria Island (2023)
Journal Article
Santana-Hernandez, K., Rodriguez-Ponce, E., Medina, I., Acosta-Hernandez, B., Priestnall, S., Vega, S., Marin, C., Cerda-Cuellar, M., Marco-Fuertes, A., Ayats, T., Beltran, T., & Lupiola-Gomez, P. (2023). One Health Approach: Invasive California Kingsnake (Lampropeltis californiae) as an Important Source of Antimicrobial Drug-Resistant Salmonella Clones on Gran Canaria Island. Animals, 13(11), https://doi.org/10.3390/ani13111790

The aim of this study was to investigate the invasive species Lampropeltis californiae (California kingsnake) as a reservoir of Salmonella and its ability to spread different clones of the bacterium with zoonotic potential into the environment, as we... Read More about One Health Approach: Invasive California Kingsnake (Lampropeltis californiae) as an Important Source of Antimicrobial Drug-Resistant Salmonella Clones on Gran Canaria Island.

Pathology and causes of death in captive meerkats (<i>Suricata suricatta</i>) (2023)
Journal Article
Martí-García, B., Priestnall, S., & Suárez-Bonnet, A. (2023). Pathology and causes of death in captive meerkats (Suricata suricatta). Veterinary Quarterly, 43(1), https://doi.org/10.1080/01652176.2023.2211120

Background Meerkats (Suricata suricatta) are endemic carnivores of southern Africa and, although currently listed as 'least concern' by the International Union for Conservation of Nature (IUCN) red list, there is evidence of a significant decrease in... Read More about Pathology and causes of death in captive meerkats (<i>Suricata suricatta</i>).

Impact of exposure to urban air pollution on grey squirrel (Sciurus carolinensis) lung health (2023)
Journal Article
Torres-Blas, I., Horsler, H., Paredes, U., Perkins, M., Priestnall, S., & Brekke, P. (2023). Impact of exposure to urban air pollution on grey squirrel (Sciurus carolinensis) lung health. Environmental Pollution, 326, https://doi.org/10.1016/j.envpol.2023.121312

The increased rate of global urbanisation has recently exacerbated the significant public health problem of traffic related air pollution. Despite the known significant impact on human health, little is known about the effects of air pollution on wil... Read More about Impact of exposure to urban air pollution on grey squirrel (Sciurus carolinensis) lung health.

' PKN2 deficiency leads both to prenatal 'congenital cardiomyopathy and defective angiotensin II stress responses (2022)
Journal Article
Marshall, J., Cull, J., Alharbi, H., Thin, M., Cooper, S., Barrington, C., Vanyai, H., Snoeks, T., Siow, B., Suaarez-Bonnet, A., Herbert, E., Stuckey, D., Cameron, A., Prin, F., Cook, A., Priestnall, S., Chotani, S., Rackham, O., Meijles, D., Mohun, T., …Parker, P. (2022). ' PKN2 deficiency leads both to prenatal 'congenital cardiomyopathy and defective angiotensin II stress responses. Biochemical Journal, 479(13), 1467-1486. https://doi.org/10.1042/BCJ20220281

Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomes (2022)
Journal Article
Berry, N., Ferguson, D., Kempster, S., Hall, J., Ham, C., Jenkins, A., Rannow, V., Giles, E., Leahy, R., Goulding, S., Fernandez, A., Adedeji, Y., Vessillier, S., Rajagopal, D., Prior, S., Le Duff, Y., Hurley, M., Gilbert, S., Fritzsche, M., Mate, R., …Almond, N. (2022). Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomes. Scientific Reports, 12(1), https://doi.org/10.1038/s41598-022-23339-x

SARS-CoV-2 exhibits a diverse host species range with variable outcomes, enabling differential host susceptibility studies to assess suitability for pre-clinical countermeasure and pathogenesis studies. Baseline virological, molecular and pathologica... Read More about Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomes.

Additional stains and immunohistochemistry: what else can the pathologist tell us? (2022)
Journal Article
Priestnall, S., & Suarez-Bonnet, A. (2022). Additional stains and immunohistochemistry: what else can the pathologist tell us?. In Practice, 44(7), 385-393. https://doi.org/10.1002/inpr.90

Background: For the veterinary pathologist, the 'bread and butter' of our work is the tissue slide stained with haematoxylin and eosin (H&E). This has long become globally recognised as the 'standard' stain, with haematoxylin highlighting the nuclei... Read More about Additional stains and immunohistochemistry: what else can the pathologist tell us?.

Histopathological description of iridophoromas resembling skin nodule syndrome in Siamese fighting fish Betta splendens (2022)
Journal Article
Oros, J., Priestnall, S., & Suarez-Bonnet, A. (2022). Histopathological description of iridophoromas resembling skin nodule syndrome in Siamese fighting fish Betta splendens. Diseases of Aquatic Organisms, 151, 23-27. https://doi.org/10.3354/dao03686

Intensive breeding of the Siamese fighting fish Betta splendens, a species that inhabits marshlands in Thailand and other countries in south-east Asia, was traditionally focused on game fighting because the males are very territorial, but has evolved... Read More about Histopathological description of iridophoromas resembling skin nodule syndrome in Siamese fighting fish Betta splendens.

EXPERIMENTALLY INDUCED DISEASE An Experimental Dermal Oedema Model for Apx Toxins of Actinobacillus pleuropneumoniae (2022)
Journal Article
Soutter, F., Priestnall, S. L., Catchpole, B., & Rycroft, A. N. (2022). EXPERIMENTALLY INDUCED DISEASE An Experimental Dermal Oedema Model for Apx Toxins of Actinobacillus pleuropneumoniae. Journal of Comparative Pathology, https://doi.org/10.1016/j.jcpa.2022.04.004

In-vivo models of Actinobacillus pleuropneumoniae (App) infection in pigs are required for the development of vaccines and investigations of pathogenicity. Existing models cause severe respiratory disease with pulmonary oedema, dyspnoea and severe th... Read More about EXPERIMENTALLY INDUCED DISEASE An Experimental Dermal Oedema Model for Apx Toxins of Actinobacillus pleuropneumoniae.

Waterhouse-Friderichsen syndrome in a cat with Klebsiella spp. infection (2021)
Journal Article
Cole, L., Hardas, A., Priestnall, S., & Tinson, E. (2021). Waterhouse-Friderichsen syndrome in a cat with Klebsiella spp. infection. Journal of Veterinary Emergency and Critical Care, 31(4), 531-536. https://doi.org/10.1111/vec.13063

Objective To describe a case of Waterhouse-Friderichsen syndrome of adrenocortical failure in a cat with Klebsiella spp. infection. Case Summary A 12-year-old male neutered domestic short-haired cat was referred for respiratory failure requiring mech... Read More about Waterhouse-Friderichsen syndrome in a cat with Klebsiella spp. infection.

Parasitological findings in the invasive California kingsnake (Lampropeltis californiae) in Gran Canaria, Spain (2021)
Journal Article
Santana-Hernandez, K., Oros, J., Priestnall, S., Monzon-Arguello, C., & Rodriguez-Ponce, E. (2021). Parasitological findings in the invasive California kingsnake (Lampropeltis californiae) in Gran Canaria, Spain. Parasitology, 148(11), 1345-1352. https://doi.org/10.1017/S0031182021000871

The California kingsnake (Lampropeltis californiae), native to North America, is a significant threat to the conservation of endemic species in the Spanish Macaronesian island of Gran Canaria. However, its role disseminating potential invasive parasi... Read More about Parasitological findings in the invasive California kingsnake (Lampropeltis californiae) in Gran Canaria, Spain.

A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza (2021)
Journal Article
Rappe, J., Finsterbusch, K., Crotta, S., Mack, M., Priestnall, S., & Wack, A. (2021). A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza. Journal of Experimental Medicine, 218(11), https://doi.org/10.1084/jem.20201631

Cytokine-mediated immune-cell recruitment and inflammation contribute to protection in respiratory virus infection. However, uncontrolled inflammation and the "cytokine storm" are hallmarks of immunopathology in severe infection. Cytokine storm is a... Read More about A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza.

The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein-losing enteropathy (2021)
Journal Article
Economu, L., Chang, Y., Priestnall, S., & Kathrani, A. (2021). The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein-losing enteropathy. Journal of Veterinary Internal Medicine, 35(3), 1297-1305. https://doi.org/10.1111/jvim.16125

Background The effect of assisted enteral feeding on treatment outcome in dogs with protein-losing enteropathy (PLE) is unknown. Objectives To determine if dogs with inflammatory PLE that had an enteral feeding tube placed had better outcome vs dogs... Read More about The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein-losing enteropathy.

Clinical presentation, treatment and outcome of canine malignant mesothelioma: A retrospective study of 34 cases (2021)
Journal Article
Larsen Moberg, H., Gramer, I., Schofield, I., Blackwood, L., Killick, D., Priestnall, L., & Guillén, A. (2022). Clinical presentation, treatment and outcome of canine malignant mesothelioma: A retrospective study of 34 cases. Veterinary and Comparative Oncology, 20(1), 304-312. https://doi.org/10.1111/vco.12777

Canine malignant mesothelioma (CMM) is a rare and aggressive tumour associated with a poor prognosis. Limited information is available regarding effective treatment options and prognostic factors. The purpose of this retrospective case series was to... Read More about Clinical presentation, treatment and outcome of canine malignant mesothelioma: A retrospective study of 34 cases.