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Cephem Potentiation by Inactivation of Nonessential Genes Involved in Cell Wall Biogenesis of ß-Lactamase-Producing Escherichia coli (2017)
Journal Article
Baker, K. R., Sigurðardóttir, H. H., Jana, B., & Guardabassi, L. (2017). Cephem Potentiation by Inactivation of Nonessential Genes Involved in Cell Wall Biogenesis of ß-Lactamase-Producing Escherichia coli. Antimicrobial Agents and Chemotherapy, 61(3), e01773-16. https://doi.org/10.1128/AAC.01773-16

Reversal of antimicrobial resistance is an appealing and largely unexplored strategy in drug discovery. The objective of this study was to identify potential targets for “helper” drugs reversing cephem resistance in Escherichia coli strains producing... Read More about Cephem Potentiation by Inactivation of Nonessential Genes Involved in Cell Wall Biogenesis of ß-Lactamase-Producing Escherichia coli.

Control of Mitochondrial Remodeling by the ATPase Inhibitory Factor 1 Unveils a Pro-survival Relay via OPA1 (2017)
Journal Article
Faccenda, D., Nakamura, J., Gorini, G., Dhoot, G. K., Piacentini, M., Yoshida, M., & Campanella, M. (2017). Control of Mitochondrial Remodeling by the ATPase Inhibitory Factor 1 Unveils a Pro-survival Relay via OPA1. Cell Reports, https://doi.org/10.1016/j.celrep.2017.01.070

The ubiquitously expressed ATPase inhibitory factor 1 (IF1) is a mitochondrial protein that blocks the reversal of the F1Fo-ATPsynthase, preventing dissipation of cellular ATP and ischemic damage. IF1 suppresses programmed cell death, enhancing tumor... Read More about Control of Mitochondrial Remodeling by the ATPase Inhibitory Factor 1 Unveils a Pro-survival Relay via OPA1.

The role of embryo movement in the development of the furcula (2017)
Journal Article
Pollard, A. S., Boyd, S., McGonnell, I. M., & Pitsillides, A. A. (2017). The role of embryo movement in the development of the furcula. Journal of Anatomy, 230(3), 435-443. https://doi.org/10.1111/joa.12571

The pectoral girdle is a complex structure which varies in its morphology between species. A major component in birds is the furcula, which can be considered equivalent to a fusion of the paired clavicles found in many mammals, and the single intercl... Read More about The role of embryo movement in the development of the furcula.

The secondary resistome of multidrug-resistant Klebsiella pneumoniae (2017)
Journal Article
Jana, B., Cain, A. K., Doerrler, W. T., Boinett, C. J., Fookes, M. C., Parkhill, J., & Guardabassi, L. (2017). The secondary resistome of multidrug-resistant Klebsiella pneumoniae. https://doi.org/10.1038/srep42483

Klebsiella pneumoniae causes severe lung and bloodstream infections that are difficult to treat due to multidrug resistance. We hypothesized that antimicrobial resistance can be reversed by targeting chromosomal non-essential genes that are not respo... Read More about The secondary resistome of multidrug-resistant Klebsiella pneumoniae.

Early animal farming and zoonotic disease dynamics: modelling brucellosis transmission in Neolithic goat populations (2017)
Journal Article
Fournié, G., Pfeiffer, D. U., & Bendrey, R. (2017). Early animal farming and zoonotic disease dynamics: modelling brucellosis transmission in Neolithic goat populations. Royal Society Open Science, 4, 160943. https://doi.org/10.1098/rsos.160943

Zoonotic pathogens are frequently hypothesized as emerging with the origins of farming, but evidence of this is elusive in the archaeological records. To explore the potential impact of animal domestication on zoonotic disease dynamics and human infe... Read More about Early animal farming and zoonotic disease dynamics: modelling brucellosis transmission in Neolithic goat populations.

Antimicrobial use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases (2017)
Journal Article
Lappin, M. R., Blondeau, J., Booth, D., Breitschwerdt, E. B., Guardabassi, L., Lloyd, D. H., …Weese, J. S. (2017). Antimicrobial use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases. Journal of Veterinary Internal Medicine, 31(2), 279-294. https://doi.org/10.1111/jvim.14627

Clinical and magnetic resonance imaging features of idiopathic oculomotor neuropathy in 14 dogs: Canine Idiopathic Oculomotor Neuropathy (2017)
Journal Article
Tetas Pont, R., Freeman, C., Dennis, R., Hartley, C., & Beltran, E. (2017). Clinical and magnetic resonance imaging features of idiopathic oculomotor neuropathy in 14 dogs: Canine Idiopathic Oculomotor Neuropathy. https://doi.org/10.1111/vru.12478

Ophthalmoplegia/ophthalmoparesis (internal, external, or both) has been reported in dogs secondary to neoplasia affecting the oculomotor nerve and is usually given a poor prognosis. The purpose of this retrospective study was to describe the clinical... Read More about Clinical and magnetic resonance imaging features of idiopathic oculomotor neuropathy in 14 dogs: Canine Idiopathic Oculomotor Neuropathy.

Antimicrobial resistance and antimicrobial use animal monitoring policies in Europe: Where are we? (2017)
Journal Article
Ferreira, J. P., & Staerk, K. D. C. (2017). Antimicrobial resistance and antimicrobial use animal monitoring policies in Europe: Where are we?. Journal of Public Health Policy, 38(2), 185-202. https://doi.org/10.1057/s41271-017-0067-y

The World Health Organization has recognized antimicrobial resistance as one of the top three threats to human health. Any use of antibiotics in animals will ultimately affect humans and vice versa. Appropriate monitoring of antimicrobial use and res... Read More about Antimicrobial resistance and antimicrobial use animal monitoring policies in Europe: Where are we?.