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Zebrafish as a model for kidney function and disease (2019)
Journal Article
Outtandy, P., Russell, C., Kleta, R., & Brockenhauer, D. (2019). Zebrafish as a model for kidney function and disease. Pediatric Nephrology, 34(5), 751-762. https://doi.org/10.1007/s00467-018-3921-7

Kidney disease is a global problem with around three million people diagnosed in the UK alone and the incidence is rising. Research is critical to develop better treatments. Animal models can help to better understand the pathophysiology behind the v... Read More about Zebrafish as a model for kidney function and disease.

Analysis of neurofilament concentration in healthy adult horses and utility in the diagnosis of equine protozoal myeloencephalitis and equine motor neuron disease (2019)
Journal Article
Morales Gómez, A. M., Zhu, S., Palmer, S., Olsen, E., Ness, S. L., Divers, T. J., Bischoff, K., & Mohammed, H. O. (2019). Analysis of neurofilament concentration in healthy adult horses and utility in the diagnosis of equine protozoal myeloencephalitis and equine motor neuron disease. Research in Veterinary Science, 125, 1-6. https://doi.org/10.1016/j.rvsc.2019.04.018

Neurofilaments (NFs) are structural proteins of neurons that are released in significant quantities in the cerebrospinal fluid and blood as a result of neuronal degeneration or axonal damage. Therefore, NFs have potential as biomarkers for neurologic... Read More about Analysis of neurofilament concentration in healthy adult horses and utility in the diagnosis of equine protozoal myeloencephalitis and equine motor neuron disease.

Surgical Treatment of a Vertebral Fracture Caused by Osseous Plasmacytoma in a Domestic Ferret (Mustela Putorius Furo) (2019)
Journal Article
Liatis, T., Gardini, A., Marçal, V. C., Foreman, M., Holloway, A., Taeymans, O., & Cherubini, G. B. (2019). Surgical Treatment of a Vertebral Fracture Caused by Osseous Plasmacytoma in a Domestic Ferret (Mustela Putorius Furo). Journal of Exotic Pet Medicine, 29, 202-206. https://doi.org/10.1053/j.jepm.2018.11.006

A 4-year-old female neutered albino domestic ferret (Mustela putorius furo) was referred for acute progressive nonambulatory paraparesis. Physical examination was unremarkable, while neurological examination revealed nonambulatory paraparesis, decrea... Read More about Surgical Treatment of a Vertebral Fracture Caused by Osseous Plasmacytoma in a Domestic Ferret (Mustela Putorius Furo).

Differential Responses of Bovine Monocyte-Derived Macrophages to Infection by Neospora caninum Isolates of High and Low Virulence (2019)
Journal Article
García-Sánchez, M., Jiménez-Pelayo, L., Horcajo, P., Regidor-Cerrillo, J., Ólafsson, E. B., Bhandage, A. K., Barragan, A., Werling, D., Ortega-Mora, L. M., & Collantes-Fernández, E. (2019). Differential Responses of Bovine Monocyte-Derived Macrophages to Infection by Neospora caninum Isolates of High and Low Virulence. Frontiers in Immunology, 10(915), https://doi.org/10.3389/fimmu.2019.00915

Neospora caninum, a protozoan parasite closely related to Toxoplasma gondii, represents one of the main causes of abortion in cattle. Macrophages (MØs) are mediators of the innate immune response against infection and likely one of the first cells en... Read More about Differential Responses of Bovine Monocyte-Derived Macrophages to Infection by Neospora caninum Isolates of High and Low Virulence.

Germline-restricted chromosome (GRC) is widespread among songbirds (2019)
Journal Article
Torgasheva, A. A., Malinovskaya, L. P., Zadesenets, K. S., Karamysheva, T. V., Kizilova, E. A., Akberdina, E. A., Pristyazhnyuk, I. E., Shnaider, E. P., Volodkina, V. A., Saifitdinova, A. F., Galkina, S. A., Larkin, D. M., Rubtsov, N. B., & Borodin, P. M. (2019). Germline-restricted chromosome (GRC) is widespread among songbirds. https://doi.org/10.1073/pnas.1817373116

An unusual supernumerary chromosome has been reported for two related avian species, the zebra and Bengalese finches. This large, germline-restricted chromosome (GRC) is eliminated from somatic cells and spermatids and transmitted via oocytes only. I... Read More about Germline-restricted chromosome (GRC) is widespread among songbirds.

Evaluation of vaccine delivery systems for inducing long-lived antibody responses to Dermanyssus gallinae antigen in laying hens (2019)
Journal Article
Price, D. R. G., Küster, T., Øines, Ø., Margaret Oliver, E., Bartley, K., Nunn, F., Barbero, J. F. L., Pritchard, J., Karp-Tatham, E., Hauge, H., Blake, D. P., Tomley, F. M., & Nisbet, A. J. (2019). Evaluation of vaccine delivery systems for inducing long-lived antibody responses to Dermanyssus gallinae antigen in laying hens. Avian Pathology, 48, S60-S74. https://doi.org/10.1080/03079457.2019.1612514

Dermanyssus gallinae, the poultry red mite, is a global threat to the commercial egg-laying industry. Control of D. gallinae is difficult, with only a limited number of effective pesticides and non-chemical treatments available. Here we characterise... Read More about Evaluation of vaccine delivery systems for inducing long-lived antibody responses to Dermanyssus gallinae antigen in laying hens.

Spaying and urinary incontinence in bitches under UK primary veterinary care: a case–control study (2019)
Journal Article
Pegram, C., O'Neill, D. G., Church, D. B., Hall, J., Owen, L., & Brodbelt, D. C. (2019). Spaying and urinary incontinence in bitches under UK primary veterinary care: a case–control study. Journal of Small Animal Practice, 60(7), 395-403

Objectives

To evaluate associations between spaying and urinary incontinence in bitches under primary veterinary care in the UK.

Materials and Methods

A case–control study was nested within the study population of 333,910 bitches, which incl... Read More about Spaying and urinary incontinence in bitches under UK primary veterinary care: a case–control study.

An investigation of polymorphisms in innate and adaptive immune response genes in canine leishmaniosis (2019)
Journal Article
Soutter, F., Solano-Gallego, L., Attipa, C., Gradoni, L., Fiorentino, E., Foglia Manzillo, V., Oliva, G., Tasker, S., Helps, C., & Catchpole, B. (2019). An investigation of polymorphisms in innate and adaptive immune response genes in canine leishmaniosis. Veterinary Parasitology, 269, 34-41. https://doi.org/10.1016/j.vetpar.2019.04.011

The outcome of infection with Leishmania infantum in dogs is variable, which is thought to be due to the nature of the immune response mounted by the host. As a consequence, the clinical signs and severity of canine leishmaniosis vary between individ... Read More about An investigation of polymorphisms in innate and adaptive immune response genes in canine leishmaniosis.

Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole genome sequencing (2019)
Journal Article
Doyle, S. R., Sankaranarayan, G., Berger, D., Jimenez Castro, P. D., Collins, J. B., Crellen, T., Duque-Correa, M. A., Ellis, P., Jaleta, T. G., Laing, R., Maitland, K., McCarthy, C., Moundai, T., Softley, B., Thiele, E., Tchindebet Ouakou, P., Tushabe, J. V., Webster, J. P., Weiss, A. J., Lok, J., …Holroyd, N. (2019). Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole genome sequencing. https://doi.org/10.1101/616672

Surgical valvulotomy for tricuspid valve stenosis in a dog (2019)
Journal Article
Bristow, P. C., Kurosawa, T. A., Fuentes, V. L., Rutherford, L., & Brockman, D. J. (2019). Surgical valvulotomy for tricuspid valve stenosis in a dog. Journal of Veterinary Cardiology, 23, 142-148. https://doi.org/10.1016/j.jvc.2019.04.002

A 2 year 4 month old female neutered Labrador retriever was presented for evaluation right sided congestive heart failure. Echocardiographic examination revealed tricuspid valve dysplasia with only two small orifices in the valve resulting in severe... Read More about Surgical valvulotomy for tricuspid valve stenosis in a dog.

The modern UK veterinary profession: photo-elicitation interviewing reveals that small animal and surgical images dominate (2019)
Journal Article
Ward, A., & May, S. A. (2019). The modern UK veterinary profession: photo-elicitation interviewing reveals that small animal and surgical images dominate. Veterinary Record, 184(21), https://doi.org/10.1136/vr.105046

More than 80 per cent of vets are employed in clinical practice but other veterinary roles are vital for society. However, even clinical practice does not seem to fulfil some modern graduates, and an increasing number of veterinarians are leaving the... Read More about The modern UK veterinary profession: photo-elicitation interviewing reveals that small animal and surgical images dominate.

Chronic kidney disease in cats attending primary care practice in the UK: a VetCompassTM study (2019)
Journal Article
Conroy, M. C., Brodbelt, D. C., O'Neill, D. G., Chang, Y. M., & Elliott, J. (2019). Chronic kidney disease in cats attending primary care practice in the UK: a VetCompassTM study. Veterinary Record, 184(17), https://doi.org/10.1136/vr.105100

Chronic kidney disease (CKD) is a frequent diagnosis in cats attending primary care practice and the most frequent cause of death in cats aged over five years, yet there is limited published research for CKD in cats attending primary care practice. T... Read More about Chronic kidney disease in cats attending primary care practice in the UK: a VetCompassTM study.

Co-circulation of genetically distinct highly pathogenic avian influenza A clade 2.3.4.4 (H5N6) viruses in wild waterfowl and poultry in Europe and East Asia, 2017–18 (2019)
Journal Article
Poen, M. J., Venkatesh, D., Bestebroer, T. M., Vuong, O., Scheuer, R. D., Oude Munnink, B. B., De Meulder, D., Richard, M., Kuiken, T., Koopmans, M. P. G., Kelder, L., Kim, Y.-J., Lee, Y.-J., Steensels, M., Lambrecht, B., Dan, A., Pohlmann, A., Beer, M., Savic, V., Brown, I. H., …Lewis, N. S. (2019). Co-circulation of genetically distinct highly pathogenic avian influenza A clade 2.3.4.4 (H5N6) viruses in wild waterfowl and poultry in Europe and East Asia, 2017–18. Virus Evolution, 5(1), vez004. https://doi.org/10.1093/ve/vez004

Highly pathogenic avian influenza (HPAI) H5 clade 2.3.4.4 viruses were first introduced into Europe in late 2014 and re-introduced in late 2016, following detections in Asia and Russia. In contrast to the 2014–15 H5N8 wave, there was substantial loca... Read More about Co-circulation of genetically distinct highly pathogenic avian influenza A clade 2.3.4.4 (H5N6) viruses in wild waterfowl and poultry in Europe and East Asia, 2017–18.

Faculty Perception of an Embedded Research Project in the Undergraduate Veterinary Curriculum (2019)
Journal Article
Cehrs, E., Pelligand, L., & Weller, R. (2019). Faculty Perception of an Embedded Research Project in the Undergraduate Veterinary Curriculum. Journal of Veterinary Medical Education,

In this article, we describe faculty’s perception of a research project embedded in the final year of the undergraduate veterinary curriculum and look at factors associated with overall perceptions of the project. We hypothesized that faculty would h... Read More about Faculty Perception of an Embedded Research Project in the Undergraduate Veterinary Curriculum.

Use of molecular and genomic data for disease surveillance in aquaculture: Towards improved evidence for decision making (2019)
Journal Article
Staerk, K. D. C., Pekala, A., & Muellner, P. (2019). Use of molecular and genomic data for disease surveillance in aquaculture: Towards improved evidence for decision making. Preventive Veterinary Medicine, 167, 190-195. https://doi.org/10.1016/j.prevetmed.2018.04.011

Diagnostic tools for the identification and confirmation of animal diseases have been evolving rapidly over the last decade, with diseases of aquatic animals being no exception. Hence, case definitions used in surveillance may now include molecular a... Read More about Use of molecular and genomic data for disease surveillance in aquaculture: Towards improved evidence for decision making.

Intra-Vitreal Administration of Microvesicles Derived from Human Adipose-Derived Multipotent Stromal Cells Improves Retinal Functionality in Dogs with Retinal Degeneration (2019)
Journal Article
Cislo-Pakuluk, A., Smieszek, A., Kucharczyk, N., Bedford, P. G. C., & Marycz, K. (2019). Intra-Vitreal Administration of Microvesicles Derived from Human Adipose-Derived Multipotent Stromal Cells Improves Retinal Functionality in Dogs with Retinal Degeneration. Journal of Clinical Medicine, 8(4), 510. https://doi.org/10.3390/jcm8040510

This study was designed to determine the influence of microvesicles (MVs) derived from multipotent stromal cells isolated from human adipose tissue (hASCs) on retinal functionality in dogs with various types of retinal degeneration. The biological pr... Read More about Intra-Vitreal Administration of Microvesicles Derived from Human Adipose-Derived Multipotent Stromal Cells Improves Retinal Functionality in Dogs with Retinal Degeneration.

Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method (2019)
Journal Article
Warboys, C. M., Ghim, M., & Weinberg, P. D. (2019). Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method. Atherosclerosis, 285, 170-177. https://doi.org/10.1016/j.atherosclerosis.2019.04.210

A striking feature of atherosclerosis is its highly non-uniform distribution within the arterial tree. This has been attributed to variation in the haemodynamic wall shear stress (WSS) experienced by endothelial cells, but the WSS characteristics tha... Read More about Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method.