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Exposure to Urban Particulate Matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response (2024)
Journal Article
Morris, R., Counsell, S., McGonnell, I., & Thornton, C. (in press). Exposure to Urban Particulate Matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response. Journal of Physiology, https://doi.org/10.1113/JP285978

World Health Organisation data suggest that up to 99% of the global population are exposed to air pollutants above recommended levels. Impacts to health range from increased risk of stroke and cardiovascular disease to chronic respiratory conditions,... Read More about Exposure to Urban Particulate Matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response.

Re-evaluating the placebo response in recent canine dietary epilepsy trials (2024)
Journal Article
Schmidt, T., Meyerhoff, N., Meller, S., Twele, F., Charalambous, M., Berk, B., Law, T., Packer, R., Zanghi, B., Pan, Y., Fischer, A., & Volk, H. (2024). Re-evaluating the placebo response in recent canine dietary epilepsy trials. BMC Veterinary Research, 20(1), https://doi.org/10.1186/s12917-024-04066-z

The placebo response is a common phenomenon. Limited evidence is available about its magnitude in canine epilepsy trials, even though it can significantly influence the efficacy evaluation of new treatments. It was hypothesised that the placebo respo... Read More about Re-evaluating the placebo response in recent canine dietary epilepsy trials.

Epidemiology of heat-related illness in dogs under UK emergency veterinary care in 2022 (2024)
Journal Article
Beard, S., Hall, E. J., Bradbury, J., Carter, A. J., Gilbert, S., & O'Neill, D. G. (2024). Epidemiology of heat-related illness in dogs under UK emergency veterinary care in 2022. Herpetological Conservation and Biology, https://doi.org/10.1002/vetr.4153

Background: Dogs are exposed to increasing environmental risk for developing heat-related illness (HRI), with 2022 recorded as the hottest year to date in the UK and most of Europe. Methods: This study used VetCompass data to report the incidence ris... Read More about Epidemiology of heat-related illness in dogs under UK emergency veterinary care in 2022.

Researcher, research thyself? Mapping the landscape of canine health and welfare research funding provided by UK not-for-profit organisations from 2012–2022 (2024)
Journal Article
O'Neill, D., Skipper, A. M., & Packer, R. M. . A. (2024). Researcher, research thyself? Mapping the landscape of canine health and welfare research funding provided by UK not-for-profit organisations from 2012–2022. Herpetological Conservation and Biology, 19(5), e0303498. https://doi.org/10.1371/journal.pone.0303498

Background Research into canine health and welfare is supported by Government, charitable and private UK funding organisations. However, there is no current overall visibility or coordination of these funding activities, potentially compromising opti... Read More about Researcher, research thyself? Mapping the landscape of canine health and welfare research funding provided by UK not-for-profit organisations from 2012–2022.

Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy (2024)
Journal Article
Poupon-Bejuit, L., Geard, A., Millicheap, N., Rocha-Ferreira, E., Hagberg, H., Thornton, C., & Rahim, A. A. (2024). Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy. EMBO Molecular Medicine, https://doi.org/10.1038/s44321-024-00079-1

Hypoxic-ischaemic encephalopathy (HIE) arises from diminished blood flow and oxygen to the neonatal brain during labor, leading to infant mortality or severe brain damage, with a global incidence of 1.5 per 1000 live births. Glucagon-like Peptide 1 R... Read More about Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy.

A prospective cohort study of factors associated with the digital cushion thickness in dairy cattle (2024)
Journal Article
Griffiths, B., Barden, M., Anagnostopoulos, A., Wilson, J., Lamprou, E., Tulley, W., Bedford, C., Psifidi, A., Banos, G., & Oikonomou, G. (2024). A prospective cohort study of factors associated with the digital cushion thickness in dairy cattle. Journal of Dairy Science, 107(9), 7230-7244. https://doi.org/10.3168/jds.2023-24563

Key factors such as stage of lactation, parity, and body fat reserves have been associated with the digital cushion thickness (DCT), however, there are discrepancies between the results of previously published studies. The objective of this study was... Read More about A prospective cohort study of factors associated with the digital cushion thickness in dairy cattle.

Spherocytosis as an indicator of fragmentation injury in dogs with splenic torsion. (2024)
Journal Article
Beeston, D., Szladovits, B., & Cortellini, S. (in press). Spherocytosis as an indicator of fragmentation injury in dogs with splenic torsion. Journal of the American Veterinary Medical Association, https://doi.org/10.2460/javma.24.03.0148

Abstract
Objective
To describe the presentation, diagnosis and treatment of four cases of splenic torsion with associated spherocytosis.

Animals
Four client-owned dogs with spherocytosis and splenic torsion.

Case Presentation
Each dog prese... Read More about Spherocytosis as an indicator of fragmentation injury in dogs with splenic torsion..

Autologous bone marrow derived mesenchymal stem cells are safe for the treatment of Achilles tendinopathy (2024)
Journal Article
Goldberg, A., Masci, L., O'Donnell, P., Green, R., Brooking, D., Bassett, P., Lowdell, M., & Smith, R. (2024). Autologous bone marrow derived mesenchymal stem cells are safe for the treatment of Achilles tendinopathy. Scientific Reports, 14(1), https://doi.org/10.1038/s41598-024-61399-3

Achilles tendinopathy is a disabling condition that affects more than 50% of runners. Pre-clinical studies in a large animal model of naturally-occurring tendinopathy similar to human Achilles tendinopathy has shown benefits of autologous bone marrow... Read More about Autologous bone marrow derived mesenchymal stem cells are safe for the treatment of Achilles tendinopathy.

A screen for <i>Plasmodium falciparum</i> sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host-pathogen interactions (2024)
Journal Article
Segireddy, R., Belda, H., Yang, A., Dundas, K., Knoeckel, J., Galaway, F., Wood, L., Quinkert, D., Knuepfer, E., Treeck, M., Wright, G., & Douglas, A. (2024). A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host-pathogen interactions. Malaria Journal, 23(1), https://doi.org/10.1186/s12936-024-04913-2

Background Sporozoite invasion of hepatocytes is an essential step in the Plasmodium life-cycle and has similarities, at the cellular level, to merozoite invasion of erythrocytes. In the case of the Plasmodium blood-stage, efforts to identify host-pa... Read More about A screen for <i>Plasmodium falciparum</i> sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host-pathogen interactions.

ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats (2024)
Journal Article
LeVine, D., Kidd, L., Garden, O., Brooks, M., Goggs, R., Kohn, B., Mackin, A., Eldermire, E., Chang, Y., Allen, J., Christopherson, P., Glanemann, B., Maruyama, H., Naskou, M., Nielsen, L., Shropshire, S., Viall, A., Birkenheuer, A., Forman, M., Hanzlicek, A., …Spada, E. (2024). ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16996

Immune thrombocytopenia (ITP) is the most common acquired primary hemostatic disorder in dogs. Immune thrombocytopenia less commonly affects cats but is an important cause of mortality and treatment-associated morbidity in both species. Immune thromb... Read More about ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats.

A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease (2024)
Journal Article
Jiang, J., Hiron, T. K., Agbaedeng, T., Malhotra, Y., Drydale, E., Bancroft, J., Ng, E., Reschen, M. E., Davison, L. J., & O’Callaghan, C. A. (2024). A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease. Circulation Research, 135(1), 6-25. https://doi.org/10.1161/circresaha.123.324172

BACKGROUND:

Coronary artery disease (CAD), the leading cause of death worldwide, is influenced by both environmental and genetic factors. Although over 250 genetic risk loci have been identified through genome-wide association studies, the specifi... Read More about A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease.

Population pharmacokinetic meta-analysis to support dosing regimen in dogs for surgical antimicrobial prophylaxis (2024)
Journal Article
Pelligand, L., Møller Sørensen, T., Cagnardi, P., Toutain, P.-L., & Allerton, F. (in press). Population pharmacokinetic meta-analysis to support dosing regimen in dogs for surgical antimicrobial prophylaxis. The Veterinary Journal, https://doi.org/10.1016/j.tvjl.2024.106136

The Pharmacokinetic/Pharmacodynamic of antimicrobial drugs (AMD) for surgical prophylaxis has been poorly studied, hampering evidence-based decision making around AMD dosing and timing. Our objective is to use PK/PD principles to inform (i) the timin... Read More about Population pharmacokinetic meta-analysis to support dosing regimen in dogs for surgical antimicrobial prophylaxis.

Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity (2024)
Journal Article
Then, C., Paillas, S., Moomin, A., Misheva, M., Moir, R., Hay, S., Bremner, D., Roberts, K., Smith, E., Heidari, Z., Sescu, D., Wang, X., Suárez-Bonnet, A., Hay, N., Murdoch, S., Saito, R., Collie-Duguid, E., Richardson, S., Priestnall, S., Wilson, J., …Kiltie, A. (2024). Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity. Microbiome, 12(1), https://doi.org/10.1186/s40168-024-01804-1

Background Non-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings showing that high-fibre diets sensitised bladder tumours to irradiation by modifying the gut microbiota... Read More about Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity.

Surgical treatment of headshaking by removal of a paracondylar process fragment via modified hyovertebrotomy approach: A detailed anatomical and surgical description in an adult horse (2024)
Journal Article
Spiesshofer, P., Hawkins, A., Berner, D., Previdelli, R., & Fiske-Jackson, A. (2024). Surgical treatment of headshaking by removal of a paracondylar process fragment via modified hyovertebrotomy approach: A detailed anatomical and surgical description in an adult horse. Veterinary Surgery, https://doi.org/10.1111/vsu.14102

ObjectiveTo describe, in detail, the relevant anatomy and surgical approach to access the paracondylar process (PCP) and report its application in a clinical case of headshaking.AnimalA seven-year-old, mixed breed mare.Study designExperimental study/... Read More about Surgical treatment of headshaking by removal of a paracondylar process fragment via modified hyovertebrotomy approach: A detailed anatomical and surgical description in an adult horse.

Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target? (2024)
Journal Article
Ritson, M., Wheeler-Jones, C. P., & Stolp, H. B. (2024). Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?. Journal of Neuroimmunology, 391, 578363. https://doi.org/10.1016/j.jneuroim.2024.578363

Neurological diseases with a neurodegenerative component have been associated with alterations in the cerebrovasculature. At the anatomical level, these are centred around changes in cerebral blood flow and vessel organisation. At the molecular level... Read More about Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?.

Life tables of annual life expectancy and risk factors for mortality in cats in the UK (2024)
Journal Article
O'Neill, D., Kendy Tzu-yun, T., Dave C, B., & David B, C. (2024). Life tables of annual life expectancy and risk factors for mortality in cats in the UK. Herpetological Conservation and Biology, 26(5), 1098612X241234556. https://doi.org/10.1177/1098612x241234556

ObjectivesThe aims of the present study were to generate the first life tables for the UK companion cat population overall as well as broken down by sex and breed status, and to quantify associations between mortality and traits such as sex, neuter s... Read More about Life tables of annual life expectancy and risk factors for mortality in cats in the UK.