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Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus (2020)
Journal Article
Faulkner, A., Tamiato, A., Cathery, W., Rampin, A., Caravaggi, C. M., Jover, E., …Madeddu, P. (2020). Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus. Diabetologia, 63(10), 2205-2217

Aims/hypothesis Treatment of vascular complications of diabetes remains inadequate. We reported that muscle pericytes (MPs) from limb muscles of vascular patients with diabetes mellitus display elevated levels of oxidative stress causing a dysfunctio... Read More about Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus.

Treatment With Hydrolyzed Diet Supplemented With Prebiotics and Glycosaminoglycans Alters Lipid Metabolism in Canine Inflammatory Bowel Disease (2020)
Journal Article
Lacombe, V. A., Capela, F., Silva, Allenspach, K., Ambrosini, Y. M., Neuber, S., …Allenspach, K. (2020). Treatment With Hydrolyzed Diet Supplemented With Prebiotics and Glycosaminoglycans Alters Lipid Metabolism in Canine Inflammatory Bowel Disease. Frontiers in Veterinary Science, 7, -. https://doi.org/10.3389/fvets.2020.00451

Canine inflammatory bowel disease (IBD) is a chronic, immunologically mediated intestinal disorder, resulting from the complex interaction of genetic, environmental and immune factors. Hydrolyzed diets are used in dogs with food-responsive diarrhea (... Read More about Treatment With Hydrolyzed Diet Supplemented With Prebiotics and Glycosaminoglycans Alters Lipid Metabolism in Canine Inflammatory Bowel Disease.

Possible Drivers of the 2019 Dengue Outbreak in Bangladesh: The Need for a Robust Community-Level Surveillance System (2020)
Journal Article
Ahsan, A., Haider, N., Kock, R., Benfield, C., & Reisen, W. (2020). Possible Drivers of the 2019 Dengue Outbreak in Bangladesh: The Need for a Robust Community-Level Surveillance System. Journal of Medical Entomology, https://doi.org/10.1093/jme/tjaa150

Bangladesh experienced its largest dengue virus (DENV) outbreak in 2019, with 101,354 patients admitted to hospital with either laboratory confirmed or clinical diagnosis. By contrast, the cumulative number of dengue patients admitted to hospitals in... Read More about Possible Drivers of the 2019 Dengue Outbreak in Bangladesh: The Need for a Robust Community-Level Surveillance System.

A history of antimicrobial drugs in animals: Evolution and revolution (2020)
Journal Article
Lees, P., Pelligand, L., Giraud, E., & Toutain, P. (2020). A history of antimicrobial drugs in animals: Evolution and revolution. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.12895

The evolutionary process of antimicrobial drug (AMD) uses in animals over a mere eight decades (1940–2020) has led to a revolutionary outcome, and both evolution and revolution are ongoing, with reports on a range of uses, misuses and abuses escalati... Read More about A history of antimicrobial drugs in animals: Evolution and revolution.

Beyond banning wildlife trade: COVID-19, conservation and development (2020)
Journal Article
Roe, D., Dickman, A., Kock, R., Milner-Gulland, E., Rihoy, E., & ’t Sas-Rolfes, M. (2020). Beyond banning wildlife trade: COVID-19, conservation and development. World Development, 136, 105121. https://doi.org/10.1016/j.worlddev.2020.105121

One of the immediate responses to COVID-19 has been a call to ban wildlife trade given the suspected origin of the pandemic in a Chinese market selling and butchering wild animals. There is clearly an urgent need to tackle wildlife trade that is ille... Read More about Beyond banning wildlife trade: COVID-19, conservation and development.

Knowledge, Attitudes and Practices of Veterinarians Towards Antimicrobial Resistance and Stewardship in Nigeria (2020)
Journal Article
Adekanye, U., Ekiri, A., Galipó, E., Muhammad, A., Mateus, A., La Ragione, R., …Cook, A. (2020). Knowledge, Attitudes and Practices of Veterinarians Towards Antimicrobial Resistance and Stewardship in Nigeria. Antibiotics, https://doi.org/10.3390/antibiotics9080453

Abstract: Antimicrobial resistance (AMR) is a global health concern and the inappropriate use of antibiotics in animals and humans are considered contributing factors. A cross-sectional survey to assess the knowledge, attitudes and practices of veter... Read More about Knowledge, Attitudes and Practices of Veterinarians Towards Antimicrobial Resistance and Stewardship in Nigeria.

Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells (2020)
Journal Article
Shah, M., Maroof, A., Gikas, P., Mittal, G., Keen, R., Baeten, D., …Roberts, S. J. (2020). Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells. RMD Open, 6(2), e001306. https://doi.org/10.1136/rmdopen-2020-001306

Objectives Interleukin (IL)-17 signalling has been shown to be a key regulator of disease in ankylosing spondylitis (AS) with several IL-17 blockers currently clinically approved. Despite this, the role of IL-17 in bone pathology is poorly understo... Read More about Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells.

Echocardiographic, morphometric and biomarker changes in female cats followed from 6 to 24 months of life (2020)
Journal Article
van Hoek, I., Laxalde, J., Connolly, D., Rush, J., & Freeman, L. (2020). Echocardiographic, morphometric and biomarker changes in female cats followed from 6 to 24 months of life. Journal of Feline Medicine and Surgery, 1098612X2094368. https://doi.org/10.1177/1098612X20943684

Objectives The aim of the study was to evaluate cardiac size and early growth through echocardiographic, bodyweight (BW), body condition score (BCS), morphometric and biomarker changes in cats followed from 6 to 24 months of age. Methods Twenty-... Read More about Echocardiographic, morphometric and biomarker changes in female cats followed from 6 to 24 months of life.

Prognostic factors and proposed grading system for cutaneous and subcutaneous soft tissue sarcomas in cats, based on a retrospective study (2020)
Journal Article
Dobromylskyj, M. J., Richards, V., & Smith, K. C. (2020). Prognostic factors and proposed grading system for cutaneous and subcutaneous soft tissue sarcomas in cats, based on a retrospective study. Journal of Feline Medicine and Surgery, 1098612X2094239. https://doi.org/10.1177/1098612x20942393

Objectives The objectives of this study included utilising a large database from a diagnostic laboratory to identify any breed, sex or age predilections for cutaneous and subcutaneous soft tissue sarcomas (STSs), and the most common anatomical locat... Read More about Prognostic factors and proposed grading system for cutaneous and subcutaneous soft tissue sarcomas in cats, based on a retrospective study.

Prednisolone-induced diabetes mellitus in the cat: a historical cohort (2020)
Journal Article
Nerhagen, S., Moberg, H., Boge, G., & Glanemann, B. (2020). Prednisolone-induced diabetes mellitus in the cat: a historical cohort. Journal of Feline Medicine and Surgery, 1098612X2094352. https://doi.org/10.1177/1098612x20943522

Objectives Prednisolone is a commonly used drug in cats and potential adverse effects include hyperglycaemia and diabetes mellitus. The aims of this study were to evaluate the frequency and investigate potential predisposing risk factors for the dev... Read More about Prednisolone-induced diabetes mellitus in the cat: a historical cohort.

Investigation of correlations between clinical signs and pathological findings in cats and dogs with inflammatory bowel disease (2020)
Journal Article
Farray, D., Rodriguez, F., Ravelo-Garcìa, A., Suarez-Bonne, A., Francisco-Arteaga, C., & Jaber, J. R. (2020). Investigation of correlations between clinical signs and pathological findings in cats and dogs with inflammatory bowel disease

This paper compares the correlation between the clinical signs and the histopathological observations of the entire intestine in cats and dogs with inflammatory bowel disease (IBD). To perform this study, hospital records of 53 dogs and 20 cats of di... Read More about Investigation of correlations between clinical signs and pathological findings in cats and dogs with inflammatory bowel disease.

Moxidectin: an oral treatment for human onchocerciasis (2020)
Journal Article
Milton, P., Hamley, J., Walker, M., & Basáñez, M. (2020). Moxidectin: an oral treatment for human onchocerciasis. Expert Review of Anti-infective Therapy, 1-15. https://doi.org/10.1080/14787210.2020.1792772

Moxidectin is a milbemycin endectocide recently approved for the treatment of human onchocerciasis. Onchocerciasis, earmarked for elimination of transmission, is a filarial infection endemic in Africa, Yemen, and the Amazonian focus straddling Venezu... Read More about Moxidectin: an oral treatment for human onchocerciasis.

Presumed generalised seizure following caudal epidural administration of morphine and detomidine in a pony (2020)
Journal Article
Tallon, R., McMillan, M., Ho, N., & Dunkel, B. (2020). Presumed generalised seizure following caudal epidural administration of morphine and detomidine in a pony. Equine Veterinary Education, https://doi.org/10.1111/eve.13342

A 9‐year‐old show pony mare became acutely lame following removal of a bone sequestrum of the distal phalanx of the right thoracic limb. The mare also suffered from ongoing right dorsal colitis secondary to previous long‐term nonsteroidal anti‐inflam... Read More about Presumed generalised seizure following caudal epidural administration of morphine and detomidine in a pony.

The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling (2020)
Journal Article
Pseftogas, A., Xanthopoulos, K., Poutahidis, T., Ainali, C., Dafou, D., Panteris, E., …Mosialos, G. (2020). The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling. Cancers, 12(8), 2047. https://doi.org/10.3390/cancers12082047

Downregulation of the cylindromatosis (CYLD) tumor suppressor has been associated with breast cancer development and progression. Here, we report a critical role for CYLD in maintaining the phenotype of mammary epithelial cells in vitro and in vivo.... Read More about The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling.

Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors (2020)
Journal Article
Bingor, A., Haham, T., Thornton, C., Stern-Bach, Y., & Yaka, R. (2020). Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors. Nature Communications, 11(1), https://doi.org/10.1038/s41467-020-17484-y

Zeta inhibitory peptide (ZIP), a PKMζ inhibitor, is widely used to interfere with the main- tenance of acquired memories. ZIP is able to erase memory even in the absence of PKMζ, via an unknown mechanism. We found that ZIP induces redistribution of t... Read More about Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors.

Evolution and epidemic spread of SARS-CoV-2 in Brazil (2020)
Journal Article
Candido, D. S., Claro, I. M., de Jesus, J. G., Souza, W. M., Moreira, F. R. R., Dellicour, S., …Faria, N. (2020). Evolution and epidemic spread of SARS-CoV-2 in Brazil. Science, eabd2161. https://doi.org/10.1126/science.abd2161

Brazil currently has one of the fastest growing SARS-CoV-2 epidemics in the world. Owing to limited available data, assessments of the impact of non-pharmaceutical interventions (NPIs) on virus spread remain challenging. Using a mobility-driven trans... Read More about Evolution and epidemic spread of SARS-CoV-2 in Brazil.

Risk indictors in cats with preclinical hypertrophic cardiomyopathy: a prospective cohort study (2020)
Journal Article
Ironside, V. A., Tricklebank, P. R., & Boswood, A. (2020). Risk indictors in cats with preclinical hypertrophic cardiomyopathy: a prospective cohort study. Journal of Feline Medicine and Surgery, 1098612X2093865

Objectives This study aimed to identify indicators of the risk of progression of preclinical hypertrophic cardiomyopathy (HCM). Methods This was a prospective cohort study following a population of cats with preclinical HCM. Cats serially underw... Read More about Risk indictors in cats with preclinical hypertrophic cardiomyopathy: a prospective cohort study.

The effect of stress fracture occurring within the first 12 months of training on subsequent race performance in Thoroughbreds in Hong Kong. (2020)
Journal Article
Johnston, A. S., Sidhu, A. B. S., Riggs, C. M., Verheyen, K. L. P., & Rosanowski, S. M. (2020). The effect of stress fracture occurring within the first 12 months of training on subsequent race performance in Thoroughbreds in Hong Kong. Equine Veterinary Journal, https://doi.org/10.1111/evj.13324

BACKGROUND Racehorses are at an increased risk of stress fracture within the first 12 months of racing and when resuming training after a break. Research in these high-risk periods and on the effect of performance post-recovery is limited. OBJE... Read More about The effect of stress fracture occurring within the first 12 months of training on subsequent race performance in Thoroughbreds in Hong Kong..