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Parkinson’s Disease-Linked Mutations in VPS35 Induce Dopaminergic Neurodegeneration (2014)
Journal Article
Tsika, E., Glauser, L., Moser, R., Fiser, A., Daniel, G., Sheerin, U., …Moore, D. J. (2014). Parkinson’s Disease-Linked Mutations in VPS35 Induce Dopaminergic Neurodegeneration. Human Molecular Genetics, 23(17), 4621-4638. https://doi.org/10.1093/hmg/ddu178

Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD). Here we explo... Read More about Parkinson’s Disease-Linked Mutations in VPS35 Induce Dopaminergic Neurodegeneration.

Low Dose of Propranolol Does Not Affect Rat Osteotomy Healing and Callus Strength (2014)
Journal Article
Smitham, P., Crossfield, L., Hughes, G., Goodship, A., Blunn, G., & Chenu, C. (2014). Low Dose of Propranolol Does Not Affect Rat Osteotomy Healing and Callus Strength. Journal of Orthopaedic Research, 32(7), 887-893. https://doi.org/10.1002/jor.22619

Experimental studies suggest that the β‐blocker propranolol stimulates bone formation but little work has investigated its effect on fracture healing. In this study, we examined if a low dose of propranolol, previously shown to be preventive against... Read More about Low Dose of Propranolol Does Not Affect Rat Osteotomy Healing and Callus Strength.

Willingness to pay for contagious bovine pleuropneumonia vaccination in Narok South District of Kenya (2014)
Journal Article
Kairu-Wanyoike, S. W., Kaitibie, S., Heffernan, C., Taylor, N. M., Gitau, G. K., Kiara, H., & McKeever, D. (2014). Willingness to pay for contagious bovine pleuropneumonia vaccination in Narok South District of Kenya. Preventive Veterinary Medicine, 115(3-4), 130-142. https://doi.org/10.1016/j.prevetmed.2014.03.028

Contagious bovine pleuropneumonia (CBPP) is an economically important trans-boundary cattle disease which affects food security and livelihoods. A conjoint analysis–contingent valuation was carried out on 190 households in Narok South District of Ken... Read More about Willingness to pay for contagious bovine pleuropneumonia vaccination in Narok South District of Kenya.

Control of contagious bovine pleuropneumonia: knowledge, attitudes, perceptions and practices in Narok district of Kenya (2014)
Journal Article
Kairu-Wanyoike, S. W., Kiara, H., Heffernan, C., Kaitibie, S., Gitau, G. K., McKeever, D., & Taylor, N. M. (2014). Control of contagious bovine pleuropneumonia: knowledge, attitudes, perceptions and practices in Narok district of Kenya. Preventive Veterinary Medicine, 115(3-4), 143-56. https://doi.org/10.1016/j.prevetmed.2014.03.029

CBPP is an important transboundary disease in sub-Saharan Africa whose control is urgent. Participatory data collection involving 52 focus group discussions in 37 village clusters and key informant interviews, a cross-sectional study involving 232 ho... Read More about Control of contagious bovine pleuropneumonia: knowledge, attitudes, perceptions and practices in Narok district of Kenya.

Substitutions near the hemagglutinin receptor-binding site determine the antigenic evolution of influenza A H3N2 viruses in U.S. swine (2014)
Journal Article
Lewis, N. S., Anderson, T. K., Kitikoon, P., Skepner, E., Burke, D. F., & Vincent, A. L. (2014). Substitutions near the hemagglutinin receptor-binding site determine the antigenic evolution of influenza A H3N2 viruses in U.S. swine. Journal of Virology, 88(9), 4752-63. https://doi.org/10.1128/JVI.03805-13

Swine influenza A virus is an endemic and economically important pathogen in pigs, with the potential to infect other host species. The hemagglutinin (HA) protein is the primary target of protective immune responses and the major component in swine i... Read More about Substitutions near the hemagglutinin receptor-binding site determine the antigenic evolution of influenza A H3N2 viruses in U.S. swine.

The reliability of observational approaches for detecting interspecific parasite interactions: comparison with experimental results (2014)
Journal Article
Fenton, A., Knowles, S. C. L., Petchey, O. L., & Pedersen, A. B. (2014). The reliability of observational approaches for detecting interspecific parasite interactions: comparison with experimental results. International Journal for Parasitology, 44(7), 437-45. https://doi.org/10.1016/j.ijpara.2014.03.001

Interactions among coinfecting parasites have the potential to alter host susceptibility to infection, the progression of disease and the efficacy of disease control measures. It is therefore essential to be able to accurately infer the occurrence an... Read More about The reliability of observational approaches for detecting interspecific parasite interactions: comparison with experimental results.

Relationships between metabolite and IGF1 concentrations with fertility and production outcomes following left abomasal displacement (2014)
Journal Article
Lyons, N. A., Cooke, J. S., Wilson, S., Van Winden, S. C. L., Gordon, P. J., & Wathes, D. C. (2014). Relationships between metabolite and IGF1 concentrations with fertility and production outcomes following left abomasal displacement. Veterinary Record, 174(26), 657-+. https://doi.org/10.1136/vr.102119

Left displacement of the abomasum (LDA) is an important periparturient disorder of dairy cows. This study evaluated differences in metabolic parameters between case-control pairs of cows (n=67) from 24 farms, and related these to outcomes in fertilit... Read More about Relationships between metabolite and IGF1 concentrations with fertility and production outcomes following left abomasal displacement.

Local overexpression of the myostatin propeptide increases glucose transporter expression and enhances skeletal muscle glucose disposal (2014)
Journal Article
Cleasby, M. E., Jarmin, S., Eilers, W., Elashry, M., Andersen, D. K., Dickson, G., & Foster, K. (2014). Local overexpression of the myostatin propeptide increases glucose transporter expression and enhances skeletal muscle glucose disposal. https://doi.org/10.1152/ajpendo.00586.2013

Insulin resistance (IR) in skeletal muscle is a prerequisite for type 2 diabetes and is often associated with obesity. IR also develops alongside muscle atrophy in older individuals in sarcopenic obesity. The molecular defects that underpin this synd... Read More about Local overexpression of the myostatin propeptide increases glucose transporter expression and enhances skeletal muscle glucose disposal.

An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum (2014)
Journal Article
Ludtmann, M. H. R., Otto, G. P., Schilde, C., Chen, Z., Allan, C. Y., Brace, S., …Williams, R. S. B. (2014). An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum. Journal of Cell Science, 127(7), 1576-1584. https://doi.org/10.1242/jcs.140939

Mutations in either of two presenilin genes can cause familial Alzheimer's disease. Presenilins have both proteolysis-dependent functions, as components of the γ-secretase complex, and proteolysis-independent functions in signalling. In this study, w... Read More about An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum.

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation (2014)
Journal Article
Kichev, A., Rousset, C. I., Baburamani, A. A., Levison, S. W., Wood, T. L., Gressens, P., …Hagberg, H. (2014). Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation. Journal of Biological Chemistry, 289(13), 9430-9439. https://doi.org/10.1074/jbc.M113.512350

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family. The interaction of TRAIL with death receptor 4 (DR4) and DR5 can trigger apoptotic cell death. The aim of this study was to investigate the role of TRAIL s... Read More about Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation.

Disturbed flow promotes endothelial senescence via a p53-dependent pathway (2014)
Journal Article
Warboys, C. M., De Luca, A., Amini, N., Luong, L., Duckles, H., Hsiao, S., …Evans, P. C. (2014). Disturbed flow promotes endothelial senescence via a p53-dependent pathway. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(5), 985-995. https://doi.org/10.1161/ATVBAHA.114.303415

Although atherosclerosis is associated with systemic risk factors such as age, high cholesterol, and obesity, plaque formation occurs predominately at branches and bends that are exposed to disturbed patterns of blood flow. The molecular mechanisms t... Read More about Disturbed flow promotes endothelial senescence via a p53-dependent pathway.

Poloxomer 188 Has a Deleterious Effect on Dystrophic Skeletal Muscle Function (2014)
Journal Article
Terry, R. L., Kaneb, H. M., & Wells, D. J. (2014). Poloxomer 188 Has a Deleterious Effect on Dystrophic Skeletal Muscle Function. PLoS ONE, 9(3), e91221. https://doi.org/10.1371/journal.pone.0091221

Duchenne muscular dystrophy (DMD) is an X-linked, fatal muscle wasting disease for which there is currently no cure and limited palliative treatments. Poloxomer 188 (P188) is a tri-block copolymer that has been proposed as a potential treatment for c... Read More about Poloxomer 188 Has a Deleterious Effect on Dystrophic Skeletal Muscle Function.

Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation (2014)
Journal Article
Pelligand, L., King, J. N., Hormazabal, V., Toutain, P. L., Elliott, J., & Lees, P. (2014). Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation. Journal of Veterinary Pharmacology and Therapeutics, 37(4), 354-366. https://doi.org/10.1111/jvp.12107

Robenacoxib and ketoprofen are acidic nonsteroidal anti‐inflammatory drugs (NSAIDs). Both are licensed for once daily administration in the cat, despite having short blood half‐lives. This study reports the pharmacokinetic/pharmacodynamic (PK/PD) mod... Read More about Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation.

Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae (2014)
Journal Article
Cadman, E. T., Thysse, K. A., Bearder, S., Cheung, A. Y. N., Johnston, A. C., Lee, J. J., & Lawrence, R. A. (2014). Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae. PLoS Pathogens, 10(3), e1003988. https://doi.org/10.1371/journal.ppat.1003988

Eosinophil responses typify both allergic and parasitic helminth disease. In helminthic disease, the role of eosinophils can be both protective in immune responses and destructive in pathological responses. To investigate whether eosinophils are invo... Read More about Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae.

Global Gene Expression Profiling of Myeloid Immune Cell Subsets in Response to In Vitro Challenge with Porcine Circovirus 2b (2014)
Journal Article
Mavrommatis, B., Offord, V., Patterson, R., Watson, M., Kanellos, T., Steinbach, F., …Werling, D. (2014). Global Gene Expression Profiling of Myeloid Immune Cell Subsets in Response to In Vitro Challenge with Porcine Circovirus 2b. PLoS ONE, 9(3), e91081. https://doi.org/10.1371/journal.pone.0091081

Compelling evidence suggests that the early interaction between porcine circovirus 2 (PCV-2) and the innate immune system is the key event in the pathogenesis of Post-Weaning Multisystemic Wasting Syndrome (PMWS). Furthermore, PCV2 has been detected... Read More about Global Gene Expression Profiling of Myeloid Immune Cell Subsets in Response to In Vitro Challenge with Porcine Circovirus 2b.

Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4) FUNCTIONAL DIFFERENCES OF NON-CATALYTIC DOMAINS OF ADAMTS-4 AND ADAMTS-5 IN LRP1 BINDING (2014)
Journal Article
Yamamoto, K., Owen, K., Parker, A. E., Scilabra, S. D., Dudhia, J., Strickland, D. K., …Nagase, H. (2014). Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4) FUNCTIONAL DIFFERENCES OF NON-CATALYTIC DOMAINS OF ADAMTS-4 AND ADAMTS-5 IN LRP1 BINDING. Journal of Biological Chemistry, 289(10), 6462-6474. https://doi.org/10.1074/jbc.M113.545376

Degradation of the cartilage proteoglycan aggrecan is an early event in the development of osteoarthritis, and a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) and ADAMTS-5 are considered to be the major aggrecan-degrading... Read More about Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4) FUNCTIONAL DIFFERENCES OF NON-CATALYTIC DOMAINS OF ADAMTS-4 AND ADAMTS-5 IN LRP1 BINDING.

Veterinary management of starved and neglected horses (2014)
Journal Article
Johns, I. C. (2014). Veterinary management of starved and neglected horses. In Practice, 36(3), https://doi.org/10.1136/inp.g1539

Starved and neglected horses can be encountered in equine practice, and veterinary surgeons have a responsibility to both treat the animal and educate the owners on animal welfare; in some cases, they may also have to deal with the authorities to sei... Read More about Veterinary management of starved and neglected horses.

Ornithine Phenylacetate targets alterations in the expression and activity of Glutamine Synthase and Glutaminase to reduce ammonia levels in bile duct ligated rats (2014)
Journal Article
Jover-Cobos, M., Noiret, L., Lee, K. C. L., Sharma, V., Habtesion, A., Romero-Gomez, M., …Jalan, R. (2014). Ornithine Phenylacetate targets alterations in the expression and activity of Glutamine Synthase and Glutaminase to reduce ammonia levels in bile duct ligated rats. Journal of Hepatology, 60(3), 545-553. https://doi.org/10.1016/j.jhep.2013.10.012

Background & Aims: In liver failure, ammonia homeostasis is dependent upon the function of the ammonia metabolising enzymes, glutamine synthetase (GS) and glutaminase (GA) but data about their protein expression and activity are lacking. The aims of... Read More about Ornithine Phenylacetate targets alterations in the expression and activity of Glutamine Synthase and Glutaminase to reduce ammonia levels in bile duct ligated rats.