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All Outputs (87)

Temporal and phylogenetic evolution of the sauropod dinosaur body plan (2016)
Journal Article
Bates, K. T., Mannion, P. D., Falkingham, P. L., Brusatte, S. L., Hutchinson, J. R., Otero, A., …Allen, V. R. (2016). Temporal and phylogenetic evolution of the sauropod dinosaur body plan. Royal Society Open Science, 3(3), 150636. https://doi.org/10.1098/rsos.150636

The colossal size and body plan of sauropod dinosaurs are unparalleled in terrestrial vertebrates. However, to date, there have been only limited attempts to examine temporal and phylogenetic patterns in the sauropod bauplan. Here, we combine three-d... Read More about Temporal and phylogenetic evolution of the sauropod dinosaur body plan.

Additive opportunistic capture explains group hunting benefits in African wild dogs (2016)
Journal Article
Hubel, T. Y., Myatt, J. P., Jordan, N. R., Dewhirst, O. P., Weldon McNutt, J., & Wilson, A. M. (2016). Additive opportunistic capture explains group hunting benefits in African wild dogs. Nature Communications, 7, 11033. https://doi.org/10.1038/ncomms11033

African wild dogs (Lycaon pictus) are described as highly collaborative endurance pursuit hunters based on observations derived primarily from the grass plains of East Africa. However, the remaining population of this endangered species mainly occupi... Read More about Additive opportunistic capture explains group hunting benefits in African wild dogs.

Energy cost and return for hunting in African wild dogs and Cheetahs (2016)
Journal Article
Hubel, T. Y., Myatt, J. P., Jordan, N. R., Dewhirst, O. P., McNutt, J. W., & Wilson, A. M. (2016). Energy cost and return for hunting in African wild dogs and Cheetahs. Nature Communications, 7, https://doi.org/10.1038/ncomms11034

African wild dogs (Lycaon pictus) are reported to hunt with energetically costly long chase distances. We used high-resolution GPS and inertial technology to record 1,119 high-speed chases of all members of a pack of six adult African wild dogs in no... Read More about Energy cost and return for hunting in African wild dogs and Cheetahs.

Disorganization of the splenic microanatomy in ageing mice (2016)
Journal Article
Aw, D. P. S., Hilliard, L., Nishikawa, Y., Cadman, E. T., Lawrence, R. A., & Palmer, D. B. (2016). Disorganization of the splenic microanatomy in ageing mice. Immunology, 148(1), 92-101. https://doi.org/10.1111/imm.12590

The precise mechanisms responsible for immunosenescence still remain to be determined, however, considering the evidence that disruption of the organization of primary and secondary lymphoid organs results in immunodeficiency, we propose that this co... Read More about Disorganization of the splenic microanatomy in ageing mice.

Enhanced flight performance by genetic manipulation of wing shape in Drosophila (2016)
Journal Article
Ray, R. P., Nakata, T., Henningsson, P., & Bomphrey, R. J. (2016). Enhanced flight performance by genetic manipulation of wing shape in Drosophila. Nature Communications, 7, https://doi.org/10.1038/ncomms10851

Insect wing shapes are remarkably diverse and the combination of shape and kinematics determines both aerial capabilities and power requirements. However, the contribution of any specific morphological feature to performance is not known. Using targe... Read More about Enhanced flight performance by genetic manipulation of wing shape in Drosophila.

Chronic kidney disease in aged cats: Clinical features, morphology, and proposed pathogeneses (2016)
Journal Article
Brown, C., Elliott, J., Schmiedt, C., & Brown, S. (2016). Chronic kidney disease in aged cats: Clinical features, morphology, and proposed pathogeneses. Veterinary Pathology, 53(2), 309-326. https://doi.org/10.1177/0300985815622975

Chronic kidney disease (CKD) is the most common metabolic disease of domesticated cats, with most affected cats being geriatric (>12 years of age). The prevalence of CKD in cats exceeds that observed in dogs, and the frequency of the diagnosis of CKD... Read More about Chronic kidney disease in aged cats: Clinical features, morphology, and proposed pathogeneses.

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease (2016)
Journal Article
Deas, E., Cremades, N., Angelova, P. R., Ludtmann, M. H. R., Yao, Z., Chen, S., …Abramov, A. Y. (2016). Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. https://doi.org/10.1089/ars.2015.6343

Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregati... Read More about Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.

Prenatal muscle development in a mouse model for the secondary dystroglycanopathies (2016)
Journal Article
Kim, J., Hopkinson, M., Kavishwar, M., Fernandez-Fuente, M., & Brown, S. C. (2016). Prenatal muscle development in a mouse model for the secondary dystroglycanopathies. Skeletal Muscle, 6(3), https://doi.org/10.1186/s13395-016-0073-y

The defective glycosylation of α-dystroglycan is associated with a group of muscular dystrophies that are collectively referred to as the secondary dystroglycanopathies. Mutations in the gene encoding fukutin-related protein (FKRP) are one of the mos... Read More about Prenatal muscle development in a mouse model for the secondary dystroglycanopathies.

Urinary active transforming growth factor ß in feline chronic kidney disease (2016)
Journal Article
Lawson, J. S., Syme, H. M., Wheeler-Jones, C. P. D., & Elliott, J. (2016). Urinary active transforming growth factor ß in feline chronic kidney disease. https://doi.org/10.1016/j.tvjl.2016.02.004

The cytokine transforming growth factor beta 1 (TGF-β1) has been widely implicated in the development and progression of renal fibrosis in chronic kidney disease (CKD) in humans and in experimental models. The aims of this study were to assess the as... Read More about Urinary active transforming growth factor ß in feline chronic kidney disease.

Lack of effect of adenosine on the function of rodent osteoblasts and osteoclasts in vitro (2016)
Journal Article
Hajjawi, M. O. R., Patel, J. J., Corcelli, M., Arnett, T. R., & Orriss, I. R. (2016). Lack of effect of adenosine on the function of rodent osteoblasts and osteoclasts in vitro. Purinergic Signalling, 12(2), 247-258. https://doi.org/10.1007/s11302-016-9499-2

Extracellular ATP, signalling through P2 receptors, exerts well-documented effects on bone cells, inhibiting mineral deposition by osteoblasts and stimulating the formation and resorptive activity of osteoclasts. The aims of this study were to determ... Read More about Lack of effect of adenosine on the function of rodent osteoblasts and osteoclasts in vitro.

Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition (2016)
Journal Article
Thorpe, C. T., Peffers, M. J., Simpson, D., Hallwell, E., Screen, H. R., & Clegg, P. D. (2016). Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition. https://doi.org/10.1038/srep20455

Tendon is a simple aligned fibre composite, consisting of collagen-rich fascicles surrounded by a softer interfascicular matrix (IFM). The composition and interactions between these material phases are fundamental in ensuring tissue mechanics meet fu... Read More about Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition.

The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice (2016)
Journal Article
Heppolette, C. A. A., Chen, J., Carr, S. K., Palmer, D. B., & Ozanne, S. E. (2016). The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice. Oncotarget, 7(6), 6398-6409. https://doi.org/10.18632/oncotarget.7176

Environmental factors such as nutrition during early life can influence long-term health, a concept termed developmental programming. Initial research was focused towards the effects on metabolic health but more recent studies have demonstrated effec... Read More about The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice.

The genomic basis of parasitism in the Strongyloides clade of nematodes (2016)
Journal Article
Hunt, V. L., Tsai, I. J., Coghlan, A., Reid, A. J., Holroyd, N., Foth, B. J., …Berriman, M. (2016). The genomic basis of parasitism in the Strongyloides clade of nematodes. Nature Genetics, 48(3), 299-307. https://doi.org/10.1038/ng.3495

Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their c... Read More about The genomic basis of parasitism in the Strongyloides clade of nematodes.

Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons (2016)
Journal Article
Thorpe, C. T., Riley, G. P., Birch, H. L., Clegg, P. D., & Screen, H. R. C. (2016). Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons. Acta Biomaterialia, 42, 308-315. https://doi.org/10.1016/j.actbio.2016.06.012

Tendon is composed of rope-like fascicles, bound together by interfascicular matrix (IFM). Our previous work shows that the IFM is critical for tendon function, facilitating sliding between fascicles to allow tendons to stretch. This function is part... Read More about Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons.