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Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection (2016)
Journal Article
Crellen, T., Allan, F., David, S., Durrant, C., Huckvale, T., Holroyd, N., …Cotton, J. A. (2016). Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection. https://doi.org/10.1038/srep20954

Schistosoma mansoni is a parasitic fluke that infects millions of people in the developing world. This study presents the first application of population genomics to S. mansoni based on high-coverage resequencing data from 10 global isolates and an i... Read More about Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection.

Urinary active transforming growth factor ß in feline chronic kidney disease (2016)
Journal Article
Lawson, J. S., Syme, H. M., Wheeler-Jones, C. P. D., & Elliott, J. (2016). Urinary active transforming growth factor ß in feline chronic kidney disease. https://doi.org/10.1016/j.tvjl.2016.02.004

The cytokine transforming growth factor beta 1 (TGF-β1) has been widely implicated in the development and progression of renal fibrosis in chronic kidney disease (CKD) in humans and in experimental models. The aims of this study were to assess the as... Read More about Urinary active transforming growth factor ß in feline chronic kidney disease.

Lack of effect of adenosine on the function of rodent osteoblasts and osteoclasts in vitro (2016)
Journal Article
Hajjawi, M. O. R., Patel, J. J., Corcelli, M., Arnett, T. R., & Orriss, I. R. (2016). Lack of effect of adenosine on the function of rodent osteoblasts and osteoclasts in vitro. Purinergic Signalling, 12(2), 247-258. https://doi.org/10.1007/s11302-016-9499-2

Extracellular ATP, signalling through P2 receptors, exerts well-documented effects on bone cells, inhibiting mineral deposition by osteoblasts and stimulating the formation and resorptive activity of osteoclasts. The aims of this study were to determ... Read More about Lack of effect of adenosine on the function of rodent osteoblasts and osteoclasts in vitro.

Risk factors for cluster seizures in canine idiopathic epilepsy (2016)
Journal Article
Packer, R. M. A., Shihab, N. K., Torres, B. B. J., & Volk, H. A. (2016). Risk factors for cluster seizures in canine idiopathic epilepsy. Research in Veterinary Science, 105, 136-138. https://doi.org/10.1016/j.rvsc.2016.02.005

Cluster seizures (CS), two or more seizures within a 24-hour period, are reported in 38–77% of dogs with idiopathic epilepsy (IE). Negative outcomes associated with CS include a reduced likelihood of achieving seizure freedom, decreased survival time... Read More about Risk factors for cluster seizures in canine idiopathic epilepsy.

Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition (2016)
Journal Article
Thorpe, C. T., Peffers, M. J., Simpson, D., Hallwell, E., Screen, H. R., & Clegg, P. D. (2016). Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition. https://doi.org/10.1038/srep20455

Tendon is a simple aligned fibre composite, consisting of collagen-rich fascicles surrounded by a softer interfascicular matrix (IFM). The composition and interactions between these material phases are fundamental in ensuring tissue mechanics meet fu... Read More about Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition.

The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice (2016)
Journal Article
Heppolette, C. A. A., Chen, J., Carr, S. K., Palmer, D. B., & Ozanne, S. E. (2016). The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice. Oncotarget, 7(6), 6398-6409. https://doi.org/10.18632/oncotarget.7176

Environmental factors such as nutrition during early life can influence long-term health, a concept termed developmental programming. Initial research was focused towards the effects on metabolic health but more recent studies have demonstrated effec... Read More about The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice.

An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling (2016)
Journal Article
Williams, R. S. B., & Bate, C. (2016). An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling. Neuropharmacology, 101, 566-575. https://doi.org/10.1016/j.neuropharm.2015.06.013

Many neurodegenerative diseases present the loss of synapses as a common pathological feature. Here we have employed an in vitro model for synaptic loss to investigate the molecular mechanism of a therapeutic treatment, valproic acid (VPA). We show t... Read More about An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling.

One Health – an Ecological and Evolutionary Framework for tackling Neglected Zoonotic Diseases (2016)
Journal Article
Webster, J. P., Gower, C. M., Knowles, S. C. L., & Fenton, A. (2016). One Health – an Ecological and Evolutionary Framework for tackling Neglected Zoonotic Diseases. Evolutionary Applications, 9(2), 313-333. https://doi.org/10.1111/eva.12341

Understanding the complex population biology and transmission ecology of multihost parasites has been declared as one of the major challenges of biomedical sciences for the 21st century and the Neglected Zoonotic Diseases (NZDs) are perhaps the most... Read More about One Health – an Ecological and Evolutionary Framework for tackling Neglected Zoonotic Diseases.

The genomic basis of parasitism in the Strongyloides clade of nematodes (2016)
Journal Article
Hunt, V. L., Tsai, I. J., Coghlan, A., Reid, A. J., Holroyd, N., Foth, B. J., …Berriman, M. (2016). The genomic basis of parasitism in the Strongyloides clade of nematodes. Nature Genetics, 48(3), 299-307. https://doi.org/10.1038/ng.3495

Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their c... Read More about The genomic basis of parasitism in the Strongyloides clade of nematodes.

Consumers' behavior in quantitative microbial risk assessment for pathogens in raw milk: Incorporation of the likelihood of consumption as a function of storage time and temperature (2016)
Journal Article
Crotta, M., Paterlini, F., Rizzi, R., & Guitian, J. (2016). Consumers' behavior in quantitative microbial risk assessment for pathogens in raw milk: Incorporation of the likelihood of consumption as a function of storage time and temperature. Journal of Dairy Science, 99(2), 1029-1038. https://doi.org/10.3168/jds.2015-10175

Vaccination control programs for multiple livestock host species: an age-stratified, seasonal transmission model for brucellosis control in endemic settings (2016)
Journal Article
Beauvais, W., Musallam, I. I., & Guitian, J. (2016). Vaccination control programs for multiple livestock host species: an age-stratified, seasonal transmission model for brucellosis control in endemic settings. https://doi.org/10.1186/s13071-016-1327-6

Brucella melitensis causes production losses in ruminants and febrile disease in humans in Africa, Central Asia, the Middle East and elsewhere. Although traditionally understood to affect primarily sheep and goats, it is also the predominant Brucella... Read More about Vaccination control programs for multiple livestock host species: an age-stratified, seasonal transmission model for brucellosis control in endemic settings.