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All Outputs (109)

Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation (2018)
Journal Article
Martinez, M., Gehring, R., Mochel, J. P., Pade, D., & Pelligand, L. (2018). Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation. Journal of Veterinary Pharmacology and Therapeutics, 41(4), E-68. https://doi.org/10.1111/jvp.12666

During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the source... Read More about Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation.

Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age (2018)
Journal Article
Núñez, J. A., Goring, A., Javaheri, B., Razi, H., Gomez-Nicola, D., Pitsillides, A. A., …Clarkin, C. E. (2018). Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age. https://doi.org/10.22203/eCM.v035a20

Cortical bone is permeated by a system of pores, occupied by the blood supply and osteocytes. With ageing, bone mass reduction and disruption of the microstructure are associated with reduced vascular supply. Insight into the regulation of the blood... Read More about Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age.

Scaling of avian bipedal locomotion reveals independent effects of body mass and leg posture on gait (2018)
Journal Article
Daley, M. A., & Birn-Jeffery, A. V. (2018). Scaling of avian bipedal locomotion reveals independent effects of body mass and leg posture on gait. Journal of Experimental Biology, 221, https://doi.org/10.1242/jeb.152538

Birds provide an interesting opportunity to study the relationships between body size, limb morphology and bipedal locomotor function. Birds are ecologically diverse and span a large range of body size and limb proportions, yet all use their hindlimb... Read More about Scaling of avian bipedal locomotion reveals independent effects of body mass and leg posture on gait.

Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs (2018)
Journal Article
O'Connor, R. E., Romanov, M. N., Kiazim, L. G., Barrett, P. M., Farre Belmonte, M., Damas, J., …Griffin, D. K. (2018). Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs. Nature Communications, 9(1), 1883. https://doi.org/10.1038/s41467-018-04267-9

Genomic organisation of extinct lineages can be inferred from extant chromosome-level genome assemblies. Here, we apply bioinformatic and molecular cytogenetic approaches to determine the genomic structure of the diapsid common ancestor. We then infe... Read More about Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs.

The grazing gait, and implications of toppling table geometry for primate footfall sequences (2018)
Journal Article
Usherwood, J. R., & Smith, B. J. H. (2018). The grazing gait, and implications of toppling table geometry for primate footfall sequences. Biology Letters, 14(5), https://doi.org/10.1098/rsbl.2018.0137

Many medium and large herbivores locomote forwards very slowly and intermittently when grazing. While the footfall order during grazing is the same as for walking, the relative fore–hind timing—phasing—is quite different. Extended periods of static s... Read More about The grazing gait, and implications of toppling table geometry for primate footfall sequences.

A dynamic simulation of musculoskeletal function in the mouse hindlimb during trotting locomotion (2018)
Journal Article
Charles, J. P., Cappellari, I., & Hutchinson, J. R. (2018). A dynamic simulation of musculoskeletal function in the mouse hindlimb during trotting locomotion. Frontiers in Bioengineering and Biotechnology, 6(61), https://doi.org/10.3389/fbioe.2018.00061

Mice are often used as animal models of various human neuromuscular diseases, and analysis of these models often requires detailed gait analysis. However, little is known of the dynamics of the mouse musculoskeletal system during locomotion. In this... Read More about A dynamic simulation of musculoskeletal function in the mouse hindlimb during trotting locomotion.

First anatomical network analysis of fore- and hindlimb musculoskeletal modularity in bonobos, common chimpanzees, and humans (2018)
Journal Article
Diogo, R., Molnar, J. L., Rolian, C., & Esteve-Altava, B. (2018). First anatomical network analysis of fore- and hindlimb musculoskeletal modularity in bonobos, common chimpanzees, and humans. https://doi.org/10.1038/s41598-018-25262-6

Studies of morphological integration and modularity, and of anatomical complexity in human evolution typically focus on skeletal tissues. Here we provide the first network analysis of the musculoskeletal anatomy of both the fore- and hindlimbs of the... Read More about First anatomical network analysis of fore- and hindlimb musculoskeletal modularity in bonobos, common chimpanzees, and humans.

Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A (2018)
Journal Article
De Ridder, D., Marino, S., Bishop, R. T., Renema, N., Chenu, C., Heymann, D., & Idris, A. I. (2018). Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A. https://doi.org/10.1038/s41598-018-25290-2

Semaphorin 3A (Sema3A), a secreted member of the Semaphorin family, increases osteoblast differentiation, stimulates bone formation and enhances fracture healing. Here, we report a previously unknown role of Sema3A in the regulation of ectopic bone f... Read More about Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A.

Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response (2018)
Journal Article
Javaheri, B., Carriero, A., Wood, M., De Souza, R., Lee, P. D., Shefelbine, S., & Pitsillides, A. A. (2018). Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response. https://doi.org/10.1038/s41598-018-25084-6

Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in bone strength. It is unclear whether this is due to failure of osteocytes to sense strain, osteoblasts to form bone or insufficient mechanical stimul... Read More about Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response.

Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter (2018)
Journal Article
Read, J. E., Cabrera-Sharp, V., Kitscha, P., Cartwright, J. E., King, P. J., Fowkes, R. C., & De Mestre, A. M. (2018). Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter. Frontiers in Endocrinology, 9, https://doi.org/10.3389/fendo.2018.00195

Equine chorionic gonadotrophin (eCG) is a placental glycoprotein critical for early equine pregnancy and used therapeutically in a number of species to support reproductive activity. The factors in trophoblast that transcriptionally regulate eCGβ-sub... Read More about Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter.

Movement patterns and athletic performance of leopards in the Okavango Delta (2018)
Journal Article
Hubel, T. Y., Golabek, K. A., Rafiq, K., Weldon McNutt, J., & Wilson, A. M. (2018). Movement patterns and athletic performance of leopards in the Okavango Delta. Proceedings of the Royal Society B: Biological Sciences, 285(4), 1017-1027. https://doi.org/10.1098/rspb.2017.2622

Although leopards are the most widespread of all the big cats and are known for their adaptability, they are elusive and little is known in detail about their movement and hunting energetics. We used high-resolution GPS/IMU (inertial measurement unit... Read More about Movement patterns and athletic performance of leopards in the Okavango Delta.

Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling (2018)
Journal Article
Al-Rashed, F., Calay, D., Lang, M., Thornton, C., Bauer, A., Kiprianos, A., …Mason, J. C. (2018). Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling. https://doi.org/10.1038/s41598-018-24548-z

Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen. We investigated the hypothesis tha... Read More about Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling.

TWEAK Receptor Deficiency Has Opposite Effects on Female and Male Mice Subjected to Neonatal Hypoxia-Ischemia (2018)
Journal Article
Kichev, A., Baburamani, A. A., Vontell, R., Gressens, P., Burkly, L., Thornton, C., & Hagberg, H. (2018). TWEAK Receptor Deficiency Has Opposite Effects on Female and Male Mice Subjected to Neonatal Hypoxia-Ischemia. Frontiers in Neurology, 9(230), https://doi.org/10.3389/fneur.2018.00230

Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine member of the TNF family. TWEAK binds to its only known receptor, Fn14, enabling it to activate downstream signaling processes in response to tissue inju... Read More about TWEAK Receptor Deficiency Has Opposite Effects on Female and Male Mice Subjected to Neonatal Hypoxia-Ischemia.

A physical model suggests that hip-localized balance sense in birds improves state estimation in perching: implications for bipedal robots (2018)
Journal Article
Urbina-Meléndez, D., Jalaleddini, K., Daley, M. A., & Valero-Cuevas, F. J. (2018). A physical model suggests that hip-localized balance sense in birds improves state estimation in perching: implications for bipedal robots. Frontiers in Robotics and AI, 5(38), https://doi.org/10.3389/frobt.2018.00038

In addition to a vestibular system, birds uniquely have a balance-sensing organ within the pelvis, called the lumbosacral organ (LSO). The LSO is well developed in terrestrial birds, possibly to facilitate balance control in perching and terrestrial... Read More about A physical model suggests that hip-localized balance sense in birds improves state estimation in perching: implications for bipedal robots.

Sperm preparation through Sephadex™ filtration improves in vitro fertilization rate of buffalo oocytes (2018)
Journal Article
Husna, A. U., Azam, A., Qadeer, S., Awan, M. A., Nasreen, S., Shahzad, Q., …Akhter, S. (2018). Sperm preparation through Sephadex™ filtration improves in vitro fertilization rate of buffalo oocytes. Reproduction in Domestic Animals, 53(2), 377-384. https://doi.org/10.1111/rda.13117

Routinely, swim-up method is used to separate high-quality sperm; however, long processing time and close cell-to-cell contact during the centrifugation step are inevitable elements of oxidative stress to sperm. The objective was to evaluate Sephadex... Read More about Sperm preparation through Sephadex™ filtration improves in vitro fertilization rate of buffalo oocytes.

Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms (2018)
Journal Article
Patel, J. J., Zhu, D., Opdebeeck, B., D'Haese, P., Millán, J. L., Bourne, L. E., …Orriss, I. R. (2018). Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms. Journal of Cellular Physiology, 233(4), 3230-3243. https://doi.org/10.1002/jcp.26166

Arterial medial calcification (AMC) is thought to share some outward similarities to skeletal mineralization and has been associated with the transdifferentiation of vascular smooth muscle cells (VSMCs) to an osteoblast‐like phenotype. ATP and UTP ha... Read More about Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms.

Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9 (2018)
Journal Article
Koo, T., Lu-Nguyen, N. B., Malerba, A., Kim, E., Kim, D., Cappellari, O., …Kim, J. (2018). Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9. Molecular Therapy, https://doi.org/10.1016/j.ymthe.2018.03.018

Duchenne muscular dystrophy (DMD) is a fatal, X-linked muscle wasting disease caused by mutations in the DMD gene. In 51% of DMD cases, a reading frame is disrupted because of deletion of several exons. Here, we show that CjCas9 derived from Campylob... Read More about Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9.

Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice (2018)
Journal Article
Javaheri, B., Razi, H., Piles, M., De Souza, R., Chang, Y. M., Maric-Mur, I., …Pitsillides, A. A. (2018). Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice. Osteoarthritis and Cartilage, 26(6), 807-817. https://doi.org/10.1016/j.joca.2018.03.008

Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OA spontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors. We exploit the lack of overt OA in female STR/Ort and i... Read More about Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice.