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Clinical and genetic characterisation of dystrophin-deficient muscular dystrophy in a family of Miniature Poodle dogs (2018)
Journal Article
Sanchez, L., Beltran, E., De Stefani, A., Guo, L. T., Shea, A., Shelton, D., …Burmeister, L. M. (2018). Clinical and genetic characterisation of dystrophin-deficient muscular dystrophy in a family of Miniature Poodle dogs. PLoS ONE, 13(23), e0193372. https://doi.org/10.1371/journal.pone.0193372

Four full-sibling intact male Miniature Poodles were evaluated at 4–19 months of age. One was clinically normal and three were affected. All affected dogs were reluctant to exercise and had generalised muscle atrophy, a stiff gait and a markedly elev... Read More about Clinical and genetic characterisation of dystrophin-deficient muscular dystrophy in a family of Miniature Poodle dogs.

Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease (2018)
Journal Article
Van Den Broek, D. H. N., Geddes, R. F., Williams, T. L., Chang, Y. M., Elliott, J., & Jepson, R. E. (2018). Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease. Journal of Veterinary Internal Medicine, 32(2), 727-735. https://doi.org/10.1111/jvim.15051

Background: Hypercalcemia is commonly associated with chronic kidney disease (CKD) in cats. Objectives: To explore the calcitonin response to naturally occurring ionized hypercalcemia in cats with azotemic CKD, and to assess the relationship of... Read More about Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease.

Advancing osteochondral tissue engineering: bone morphogenetic protein, transforming growth factor, and fibroblast growth factor signaling drive ordered differentiation of periosteal cells resulting in stable cartilage and bone formation in vivo. (2018)
Journal Article
Mendes, L. F., Katairi, H., Tam, W. L., Chai, Y. C., Geris, L., Roberts, S. J., & Luyten, F. P. (2018). Advancing osteochondral tissue engineering: bone morphogenetic protein, transforming growth factor, and fibroblast growth factor signaling drive ordered differentiation of periosteal cells resulting in stable cartilage and bone formation in vivo. https://doi.org/10.1186/s13287-018-0787-3

Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats (2018)
Journal Article
Geddes, R. F., Jepson, R. E., Forcada, Y., Elliott, J., & Syme, H. M. (2018). Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats. https://doi.org/10.1016/j.tvjl.2018.02.010

Feline chronic kidney disease (CKD) is associated with high variability in severity of CKD-mineral and bone disorder (CKD-MBD). The calcium sensing receptor (CaSR) regulates circulating parathyroid hormone (PTH) and calcium concentrations. Single nuc... Read More about Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats.

Veterinary Parasitology Teaching at London – Meeting the ‘Day-One Competency’ Needs of New Veterinarians (2018)
Journal Article
Fox, M. T., Blake, D. P., & Jacobs, D. E. (2018). Veterinary Parasitology Teaching at London – Meeting the ‘Day-One Competency’ Needs of New Veterinarians. Veterinary Parasitology, 254, 131-134. https://doi.org/10.1016/j.vetpar.2018.01.029

Over the past four decades, there has been an exponential increase in veterinary parasitology knowledge, coinciding with the advent of molecular biology in research. Therefore, it is unrealistic for teachers to expect students to graduate with an enc... Read More about Veterinary Parasitology Teaching at London – Meeting the ‘Day-One Competency’ Needs of New Veterinarians.

The influence of speed and size on avian terrestrial locomotor biomechanics: predicting locomotion in extinct theropod dinosaurs (2018)
Journal Article
Bishop, P. J., Clemente, C. J., Graham, D. F., Lamas, L. P., Hutchinson, J. R., Rubenson, J., …Lloyd, D. G. (2018). The influence of speed and size on avian terrestrial locomotor biomechanics: predicting locomotion in extinct theropod dinosaurs. PLoS ONE, 13(2), e0192172. https://doi.org/10.1371/journal.pone.0192172

How extinct, non-avian theropod dinosaurs moved is a subject of considerable interest and controversy. A better understanding of non-avian theropod locomotion can be achieved by better understanding terrestrial locomotor biomechanics in their modern... Read More about The influence of speed and size on avian terrestrial locomotor biomechanics: predicting locomotion in extinct theropod dinosaurs.

Caudal articular process dysplasia of thoracic vertebrae in neurologically normal French bulldogs, English bulldogs, and Pugs: Prevalence and characteristics (2018)
Journal Article
Bertram, S., Ter Haar, G., & De Decker, S. (2018). Caudal articular process dysplasia of thoracic vertebrae in neurologically normal French bulldogs, English bulldogs, and Pugs: Prevalence and characteristics. https://doi.org/10.1111/vru.12609

The aims of this study were to evaluate the prevalence and anatomical characteristics of thoracic caudal articular process dysplasia in French bulldogs, English bulldogs and Pugs presenting for problems unrelated to spinal disease. In this retrospect... Read More about Caudal articular process dysplasia of thoracic vertebrae in neurologically normal French bulldogs, English bulldogs, and Pugs: Prevalence and characteristics.

Development of clinical sign-based scoring system for assessment of omphalitis in neonatal calves (2018)
Journal Article
Steerforth, D., & Van Winden, S. C. L. (2018). Development of clinical sign-based scoring system for assessment of omphalitis in neonatal calves. Veterinary Record, https://doi.org/10.1136/vr.104213

Omphalitis contributes significantly to morbidity and mortality in neonatal calves. Diagnosis of omphalitis is based on the local signs of inflammation—pain, swelling, local heat and purulent discharge. An abattoir trial identified an optimal, sign-b... Read More about Development of clinical sign-based scoring system for assessment of omphalitis in neonatal calves.

Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry (2018)
Journal Article
Pittaway, R., Wu, Y., Suárez-Bonnet, A., Szladovits, B., Scurrell, E. J., Garden, O. A., …Priestnall, S. L. (2018). Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry. Journal of Veterinary Diagnostic Investigation, https://doi.org/10.1177/1040638718760965

Anaplastic large-cell lymphoma or null-cell lymphoma is a clinical entity reported in people, classified according to the unique appearance of large pleomorphic cells that express CD30. Null-cell lymphoma has also been described in dogs when neither... Read More about Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry.

The companion dog as a model for human aging and mortality (2018)
Journal Article
Hoffman, J. M., Creevy, K. E., Franks, A., O'Neill, D. G., & Promislow, D. E. L. (2018). The companion dog as a model for human aging and mortality. Aging Cell, 17(3), e12737. https://doi.org/10.1111/acel.12737

Around the world, human populations have experienced large increases in average lifespan over the last 150 years, and while individuals are living longer, they are spending more years of life with multiple chronic morbidities. Researchers have used n... Read More about The companion dog as a model for human aging and mortality.

Cognitive dysfunction in naturally occurring canine idiopathic epilepsy (2018)
Journal Article
Packer, R. M. A., McGreevy, P. D., Salvin, H. E., Valenzuela, M. J., Chaplin, C. M., & Volk, H. A. (2018). Cognitive dysfunction in naturally occurring canine idiopathic epilepsy. PLoS ONE, 13(2), e0192182. https://doi.org/10.1371/journal.pone.0192182

Globally, epilepsy is a common serious brain disorder. In addition to seizure activity, epilepsy is associated with cognitive impairments including static cognitive impairments present at onset, progressive seizure-induced impairments and co-morbid d... Read More about Cognitive dysfunction in naturally occurring canine idiopathic epilepsy.

Spatial relationship between bone formation and mechanical stimulus within cortical bone: Combining 3D fluorochrome mapping and poroelastic finite element modelling (2018)
Journal Article
Carriero, A., Pereira, A. F., Wilson, A. J., Castagno, S., Javaheri, B., Pitsillides, A. A., …Shefelbine, S. J. (2018). Spatial relationship between bone formation and mechanical stimulus within cortical bone: Combining 3D fluorochrome mapping and poroelastic finite element modelling. https://doi.org/10.1016/j.bonr.2018.02.003

Bone is a dynamic tissue and adapts its architecture in response to biological and mechanical factors. Here we investigate how cortical bone formation is spatially controlled by the local mechanical environment in the murine tibia axial loading model... Read More about Spatial relationship between bone formation and mechanical stimulus within cortical bone: Combining 3D fluorochrome mapping and poroelastic finite element modelling.

Proposal of serovars 17 and 18 of Actinobacillus pleuropneumoniae based on serological and genotypic analysis (2018)
Journal Article
Bossé, J. T., Li, Y., Sárközi, R., Fodor, L., Lacouture, S., Gottschalk, M., …Langford, P. R. (2018). Proposal of serovars 17 and 18 of Actinobacillus pleuropneumoniae based on serological and genotypic analysis. Veterinary Microbiology, 217, 1-6. https://doi.org/10.1016/j.vetmic.2018.02.019

The aim of this study was to investigate isolates of Actinobacillus pleuropneumoniae previously designated serologically either as NT or as ‘K2:07’, which did not produce serovar-specific amplicons in PCR assays. We used whole genome sequencing to... Read More about Proposal of serovars 17 and 18 of Actinobacillus pleuropneumoniae based on serological and genotypic analysis.

Effectiveness of pneumatically powered penetrating and non-penetrating captive bolts in stunning cattle (2018)
Journal Article
Oliveira, S. E. O., Gregory, N. G., Costa, F. A. D., Gibson, T. J., Costa, O. A. D., & Da Costa, M. J. R. P. (2018). Effectiveness of pneumatically powered penetrating and non-penetrating captive bolts in stunning cattle. Meat Science, 140, 9-13. https://doi.org/10.1016/j.meatsci.2018.02.010

This study assessed the effectiveness of penetrating (PCB; 190 psi; N = 363) and non-penetrating captive bolt guns (NPCB; 210–220 psi; N = 92) to stun a total of 455 cattle (Zebu and Zebu Cross). Physical bolt parameters (momentum, kinetic energy and... Read More about Effectiveness of pneumatically powered penetrating and non-penetrating captive bolts in stunning cattle.

Longitudinal changes in telomere length and associated genetic parameters in dairy cattle analysed using random regression models (2018)
Journal Article
Seeker, L. A., Ilska, J. J., Psifidi, A., Wilbourn, R. V., Underwood, S. L., Fairlie, J., …Banos, G. (2018). Longitudinal changes in telomere length and associated genetic parameters in dairy cattle analysed using random regression models. PLoS ONE, 13(2), https://doi.org/10.1371/journal.pone.0192864

Telomeres cap the ends of linear chromosomes and shorten with age in many organisms. In humans short telomeres have been linked to morbidity and mortality. With the accumulation of longitudinal datasets the focus shifts from investigating telomere le... Read More about Longitudinal changes in telomere length and associated genetic parameters in dairy cattle analysed using random regression models.

Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model (2018)
Journal Article
Sahakyan, V., Duelen, R., Tam, W. L., Roberts, S. J., Grosemans, H., Berckmans, P., …Sampaolesi, M. (2018). Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model. Nature, 8, 2942. https://doi.org/10.1038/s41598-018-21103-8

Neural tube defects (NTDs) are severe congenital abnormalities, caused by failed closure of neural tube during early embryonic development. Periconceptional folic acid (FA) supplementation greatly reduces the risk of NTDs. However, the molecular mech... Read More about Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.

Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS) (2018)
Journal Article
Kondori, N. R., Paul, P., Robbins, J. P., Liu, K., Hildyard, J. C. W., Wells, D. J., & De Belleroche, J. S. (2018). Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS). Frontiers in Molecular Biosciences, 5(8), https://doi.org/10.3389/fmolb.2018.00008

Highly pathogenic avian influenza (HPAI) H5N1 virus has been circulating in Vietnam since 2003, while outbreaks of HPAI H5N6 virus are more recent, having only been reported since 2014. Although the spatial distribution of H5N1 outbreaks and risk fac... Read More about Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS).

Surgical repair of propagating condylar fractures of the third metacarpal/metatarsal bones with cortical screws placed in lag fashion in 26 racehorses (2007–2015) (2018)
Journal Article
Moulin, N., François, I., Coté, N., Alford, C., Cleary, O., & Desjardins, M. R. (2018). Surgical repair of propagating condylar fractures of the third metacarpal/metatarsal bones with cortical screws placed in lag fashion in 26 racehorses (2007–2015). Equine Veterinary Journal, 50(5), 629-635. https://doi.org/10.1111/evj.12811