Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition
(2021)
Journal Article
Sharma, A., Goring, A., Johnson, P., Emery, R., Hesse, E., Boyde, A., …Clarkin, C. (2021). Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition. Disease Models and Mechanisms, 14(3), https://doi.org/10.1242/dmm.048116
Collagen assembly during development is essential for successful matrix mineralisation, which determines bone quality and mechanocompetence. However, the biochemical and structural perturbations that drive pathological skeletal collagen configuration... Read More about Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition.