Characterization of contemporary 2010.1 H3N2 swine influenza A viruses circulating in United States pigs

Powell, JD; Abente, EJ; Chang, J; Souza, CK; Rajao, DS; Anderson, TK; Zeller, MA; Gauger, PC; Lewis, NS; Vincent, AL

doi:10.1016/j.virol.2020.11.006

Characterization of contemporary 2010.1 H3N2 swine influenza A viruses circulating in United States pigs

Powell, JD; Abente, EJ; Chang, J; Souza, CK; Rajao, DS; Anderson, TK; Zeller, MA; Gauger, PC; Lewis, NS; Vincent, AL

Authors

JD Powell

EJ Abente

J Chang

CK Souza

DS Rajao

TK Anderson

MA Zeller

PC Gauger

NS Lewis

AL Vincent

Abstract

In 2012, swine influenza surveillance detected a novel reassorted influenza A virus (IAV) strain containing human-seasonal hemagglutinin (HA) and neuraminidase (NA). Subsequently, these viruses reassorted, maintaining only the human-origin H3, which resulted in a new lineage of viruses that became the most frequently detected H3 Glade in US swine (2010.1 HA Glade). Here, we assessed the antigenic phenotype, virulence, and transmission characteristics of this virus lineage following its introduction to swine. Relative to 2010.1 viruses from 2012 and 2014, recent 2010.1 contemporary strains from 2015 to 2017 resulted in equivalent macroscopic lung lesions and transmission in pigs. A single mutation at amino acid residue 145 within the previously defined HA antigenic motif was associated with a change of antigenic phenotype, potentially impairing vaccine efficacy. Contemporary 2010.1 viruses circulating in swine since 2012 were significantly different from both pre-2012H3N2 in swine and human-seasonal H3N2 viruses and demonstrated continued evolution within the lineage.

Citation

Powell, J., Abente, E., Chang, J., Souza, C., Rajao, D., Anderson, T., Zeller, M., Gauger, P., Lewis, N., & Vincent, A. (2021). Characterization of contemporary 2010.1 H3N2 swine influenza A viruses circulating in United States pigs. Journal of Virology, 553, 94-101. https://doi.org/10.1016/j.virol.2020.11.006

Journal Article Type	Article
Acceptance Date	Nov 18, 2020
Publication Date	2021
Deposit Date	Jan 6, 2022
Publicly Available Date	Jan 6, 2022
Print ISSN	0022-538X
Electronic ISSN	1098-5514
Publisher	American Society for Microbiology
Peer Reviewed	Peer Reviewed
Volume	553
Pages	94-101
DOI	https://doi.org/10.1016/j.virol.2020.11.006
Keywords	Influenza A; H3N2; H3N1; Swine; H3N2v; Antigenic motif; BINDING SITE DETERMINE; GENETIC EVOLUTION; ANTIGENIC DRIFT; HEMAGGLUTININ; SUBSTITUTIONS; RESOURCE; FAIRS
Public URL	https://rvc-repository.worktribe.com/output/1554272