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All Outputs (403)

Such a tease! Production and uses of teaser rams, bucks, boars and bulls (2022)
Journal Article
Crilly, J., Reilly, B., & Wood, M. (2022). Such a tease! Production and uses of teaser rams, bucks, boars and bulls. In Practice, 44(4), 228-238. https://doi.org/10.1002/inpr.204

Background: Male livestock rendered sterile through vasectomy or epididymectomy, but still hormonally and behaviourally sexually active, have many uses. In small ruminants they can be used to advance the breeding season and puberty, synchronise and d... Read More about Such a tease! Production and uses of teaser rams, bucks, boars and bulls.

PRD-Class Homeobox Genes in Bovine Early Embryos: Function, Evolution, and Overlapping Roles (2022)
Journal Article
Lewin, T., Fouladi-Nashta, A., & Holland, P. (2022). PRD-Class Homeobox Genes in Bovine Early Embryos: Function, Evolution, and Overlapping Roles. Molecular Biology and Evolution, 39(5), https://doi.org/10.1093/molbev/msac098

Eutherian Totipotent Cell Homeobox (ETCHbox) genes are mammalian-specific PRD-class homeobox genes with conserved expression in the preimplantation embryo but fast-evolving and highly divergent sequences. Here, we exploit an ectopic expression approa... Read More about PRD-Class Homeobox Genes in Bovine Early Embryos: Function, Evolution, and Overlapping Roles.

Hostage to history - questioning the duration of systemic antimicrobial therapy for the treatment of canine superficial bacterial folliculitis (2022)
Journal Article
Sousa, C., Chatfield, J., File, T., Koch, S., Leu, D., Loeffler, A., …Weese, J. (2022). Hostage to history - questioning the duration of systemic antimicrobial therapy for the treatment of canine superficial bacterial folliculitis. Journal of the American Veterinary Medical Association, 260(10), 1153-1156. https://doi.org/10.2460/javma.22.03.0113

The efficacy of vapocoolant spray for reducing intravenous catheter pain in emergency patients (2022)
Journal Article
Trinder, R., Humm, K., & Cole, L. (2022). The efficacy of vapocoolant spray for reducing intravenous catheter pain in emergency patients. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13504

Objective: This study aimed to determine if dogs and cats presenting as an emergency had improved tolerance of intravenous catheterisation following the application of vapocoolant spray when compared to a saline control. Method: A randomised con... Read More about The efficacy of vapocoolant spray for reducing intravenous catheter pain in emergency patients.

Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways (2022)
Journal Article
Prendecki, M., McAdoo, S., Turner-Stokes, T., Garcia-Diaz, A., Orriss, I., Woollard, K., …Tam, F. (2022). Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways. Journal of Pathology, 257(3), 300-313. https://doi.org/10.1002/path.5890

P2RX7, an ionotropic receptor for extracellular adenosine triphosphate (ATP), is expressed on immune cells, including macrophages, monocytes, and dendritic cells and is upregulated on nonimmune cells following injury. P2RX7 plays a role in many biolo... Read More about Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways.

2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 1- Defining populations at risk (2022)
Journal Article
Chan, D., deLaforcade, A., Bacek, L., Boyd, C., Blais, M., Brainard, B., …Sharp, C. (2022). 2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 1- Defining populations at risk. Journal of Veterinary Emergency and Critical Care,

Abstract Objectives: To expand the number of conditions and interventions explored for the associations with thrombosis in the veterinary literature, and to provide the basis for prescribing recommendations. Design: A population exposure compari... Read More about 2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 1- Defining populations at risk.

The Design of a Low Noise, Multi-Channel Recording System for Use in Implanted Peripheral Nerve Interfaces (2022)
Journal Article
Sadrafshari, S., Metcalfe, B., Donaldson, N., Granger, N., Prager, J., & Taylor, J. (2022). The Design of a Low Noise, Multi-Channel Recording System for Use in Implanted Peripheral Nerve Interfaces. Sensors, 22(9), https://doi.org/10.3390/s22093450

In the development of implantable neural interfaces, the recording of signals from the peripheral nerves is a major challenge. Since the interference from outside the body, other biopotentials, and even random noise can be orders of magnitude larger... Read More about The Design of a Low Noise, Multi-Channel Recording System for Use in Implanted Peripheral Nerve Interfaces.

INDIVIDUAL IDENTIFICATION OF THE LAKE OKU CLAWED FROG (XENOPUS LONGIPES) USING A PHOTOGRAPHIC IDENTIFICATION TECHNIQUE (2022)
Journal Article
Aevarsson, U., Graves, A., Carter, K., Doherty-Bone, T., Kane, D., Servini, F., …Michaels, C. (2022). INDIVIDUAL IDENTIFICATION OF THE LAKE OKU CLAWED FROG (XENOPUS LONGIPES) USING A PHOTOGRAPHIC IDENTIFICATION TECHNIQUE. Herpetological Conservation and Biology, 17(1), 67-75

Amphibians are challenging to mark for recapture due to their small size and permeable, sensitive, and often frequently shed skins. Photographic identification and pattern matching techniques are increasingly used as a non-invasive method to identify... Read More about INDIVIDUAL IDENTIFICATION OF THE LAKE OKU CLAWED FROG (XENOPUS LONGIPES) USING A PHOTOGRAPHIC IDENTIFICATION TECHNIQUE.

Assessing Animal Welfare: A triangulation of preference, judgement bias and other candidate welfare indicators (2022)
Journal Article
Paul, E., Browne, W., Mendl, M., Caplen, G., Trevarthen, A., Held, S., & Nicol, C. (2022). Assessing Animal Welfare: A triangulation of preference, judgement bias and other candidate welfare indicators. Animal Behaviour, https://doi.org/10.1016/j.anbehav.2022.02.003

To assess the welfare of captive animals, validated measures – so called “welfare indicators” - are required. We used a triangulation approach to investigate the extent to which different measures converged to provide corroborating evidence of welfar... Read More about Assessing Animal Welfare: A triangulation of preference, judgement bias and other candidate welfare indicators.

Feline Comorbidities: Balancing Hyperthyroidism and Concurrent Chronic Kidney Disease (2022)
Journal Article
Geddes, R., & Aguiar, J. (2022). Feline Comorbidities: Balancing Hyperthyroidism and Concurrent Chronic Kidney Disease. Journal of Feline Medicine and Surgery, https://doi.org/10.1177/1098612X221090390

Practical relevance - Both hyperthyroidism and chronic kidney disease are common long-lasting conditions in older cats, which might be diagnosed concurrently or develop at different times. Hyperthyroidism may mask the presence of chronic kidney disea... Read More about Feline Comorbidities: Balancing Hyperthyroidism and Concurrent Chronic Kidney Disease.

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor (2022)
Journal Article
Miller, D., Reuillon, T., Molyneux, L., Blackburn, T., Cook, S., Edwards, N., …Cano, C. (2022). Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. Journal of Medicinal Chemistry, 65(9), 6513-6540. https://doi.org/10.1021/acs.jmedchem.1c01756

The nonclassical extracellular signal-related kinase 5 (ERK5) mitogen-activated protein kinase pathway has beenimplicated in increased cellular proliferation, migration, survival, and angiogenesis; hence, ERK5 inhibition may be an attractiveapproach... Read More about Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.

Phylogenetic analysis of migration, differentiation, and class switching in B cells (2022)
Journal Article
Hoehn, K., Pybus, O., & Kleinstein, S. (2022). Phylogenetic analysis of migration, differentiation, and class switching in B cells. PLoS Computational Biology, 18(4), https://doi.org/10.1371/journal.pcbi.1009885

B cells undergo rapid mutation and selection for antibody binding affinity when producing antibodies capable of neutralizing pathogens. This evolutionary process can be intermixed with migration between tissues, differentiation between cellular subse... Read More about Phylogenetic analysis of migration, differentiation, and class switching in B cells.

Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints (2022)
Journal Article
Ajami, S., Javaheri, B., Chang, Y., Maruthainar, N., Khan, T., Donaldson, J., …Liu, C. (2022). Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints. Scientific Reports, 12(1), https://doi.org/10.1038/s41598-022-10600-6

Early diagnosis of osteoarthritis (OA), before the onset of irreversible changes is crucial for understanding the disease process and identifying potential disease-modifying treatments from the earliest stage. OA is a whole joint disease and affects... Read More about Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints.

Revisiting the original Akin technique: A comparative analysis of radiographic outcome (2022)
Journal Article
Dellonder-Frigole, J., Matas-Pareja, M., Calle-Garcia, J., Bowen, J., Fatjo-Rios, J., & Alberti-Fito, G. (2022). Revisiting the original Akin technique: A comparative analysis of radiographic outcome. Foot and Ankle Surgery, 28(3), 394-401. https://doi.org/10.1016/j.fas.2021.05.004

Background: The Akin osteotomy is widely used to correct the hallux valgus and different fixation techniques have been proposed. Currently most of these procedures coexist, with disagreement on which offers the best results. The aim of this study is... Read More about Revisiting the original Akin technique: A comparative analysis of radiographic outcome.